CRCGN012_HEPG2_24H:B20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-oxydianiline 20.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN012_HEPG2_24H:B20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPP38 ribonuclease P/MRP 38kDa subunit 8.93288
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.49967
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.21193
LCN2 lipocalin 2 5.12143
CHMP6 charged multivesicular body protein 6 4.56358
SYNE2 spectrin repeat containing, nuclear envelope 2 4.53633
TAC4 tachykinin 4 (hemokinin) 4.46559
E2F2 E2F transcription factor 2 4.35361
CSK c-src tyrosine kinase 4.27626
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.21724
CARMIL1 capping protein regulator and myosin 1 linker 1 4.16671
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.6466
RXYLT1 ribitol xylosyltransferase 1 3.23375
CCL2 chemokine (C-C motif) ligand 2 3.17677
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.14448
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.03564
CEP57 centrosomal protein 57kDa 3.0267
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.01777
KIF14 kinesin family member 14 2.87263
LOC122526780 uncharacterized LOC122526780 2.64117
TIAM1 T-cell lymphoma invasion and metastasis 1 2.59098
ATP11B ATPase, class VI, type 11B 2.56228
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.53688
HYOU1 hypoxia up-regulated 1 2.53274
TXNL4B thioredoxin-like 4B 2.3406
GATA3 GATA binding protein 3 2.31353
CREG1 cellular repressor of E1A-stimulated genes 1 2.30213
ECHDC3 enoyl CoA hydratase domain containing 3 2.28941
SLAMF7 SLAM family member 7 2.28419
CCNH cyclin H 2.26568
MEST mesoderm specific transcript 2.21495
TBP TATA box binding protein 2.05941
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.02061

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -6.55391
NUP93 nucleoporin 93kDa -5.65699
CD320 CD320 molecule -5.5839
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.5142
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.07965
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -4.69333
ZMIZ1 zinc finger, MIZ-type containing 1 -4.54584
COG2 component of oligomeric golgi complex 2 -4.1715
MRPS2 mitochondrial ribosomal protein S2 -4.11307
SLC35F2 solute carrier family 35, member F2 -4.07978
ISOC1 isochorismatase domain containing 1 -4.07217
RPS5 ribosomal protein S5 -3.63524
DERA deoxyribose-phosphate aldolase (putative) -3.56084
GDF15 growth differentiation factor 15 -3.46419
CCNB2 cyclin B2 -3.3581
FGFR4 fibroblast growth factor receptor 4 -3.26738
ETFB electron-transfer-flavoprotein, beta polypeptide -3.10296
PEG10 paternally expressed 10 -2.92204
SNX11 sorting nexin 11 -2.80378
NRIP1 nuclear receptor interacting protein 1 -2.68937
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.68012
CCNB1 cyclin B1 -2.61917
TRIM24 tripartite motif containing 24 -2.21555
TM9SF2 transmembrane 9 superfamily member 2 -2.18956
ACAA1 acetyl-CoA acyltransferase 1 -2.1828
RAB23 RAB23, member RAS oncogene family -2.12016
FXYD7 FXYD domain containing ion transport regulator 7 -2.09248
RPL34 ribosomal protein L34 -2.06959
ITGB1BP1 integrin beta 1 binding protein 1 -2.05202
HMOX1 heme oxygenase 1 -2.02673