CRCGN012_HEPG2_24H:B23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-oxydianiline 2.52 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN012_HEPG2_24H:B23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.78803
CSK c-src tyrosine kinase 4.64504
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.63445
E2F2 E2F transcription factor 2 4.60977
DYNLT3 dynein, light chain, Tctex-type 3 4.5571
ATP11B ATPase, class VI, type 11B 4.54952
NMU neuromedin U 4.41291
RPP38 ribonuclease P/MRP 38kDa subunit 4.38028
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.28936
UBQLN2 ubiquilin 2 4.26768
NANOS3 nanos homolog 3 (Drosophila) 4.19561
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.16278
STIMATE STIM activating enhancer 4.06946
LCN2 lipocalin 2 3.85049
ABHD6 abhydrolase domain containing 6 3.81512
SNAP25 synaptosomal-associated protein, 25kDa 3.7956
MOK MOK protein kinase 3.44633
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.14225
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.08525
HSPA1A heat shock 70kDa protein 1A 3.07449
LPAR2 lysophosphatidic acid receptor 2 3.00731
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.88641
TIAM1 T-cell lymphoma invasion and metastasis 1 2.79377
DENND2D DENN/MADD domain containing 2D 2.70782
GPATCH8 G patch domain containing 8 2.60522
HMGN3 high mobility group nucleosomal binding domain 3 2.58205
CHEK2 checkpoint kinase 2 2.41623
NOSIP nitric oxide synthase interacting protein 2.40628
ANO1 anoctamin 1, calcium activated chloride channel 2.31498
CEP57 centrosomal protein 57kDa 2.29503
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.20454
GSTK1 glutathione S-transferase kappa 1 2.17589
EDN1 endothelin 1 2.14124
EVI2B ecotropic viral integration site 2B 2.13321
RIGI RNA sensor RIG-I 2.09128
COL9A2 collagen, type IX, alpha 2 2.08233
CALY calcyon neuron-specific vesicular protein 2.0346
PLSCR3 phospholipid scramblase 3 2.03396
TCEAL4 transcription elongation factor A (SII)-like 4 2.02179
TUBA4A tubulin, alpha 4a 2.0013

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.92832
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -5.50231
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.35189
LDHD lactate dehydrogenase D -5.05936
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.9889
ZNF586 zinc finger protein 586 -4.78415
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.49461
PCCB propionyl CoA carboxylase, beta polypeptide -4.43796
ADI1 acireductone dioxygenase 1 -4.42814
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.23093
MTFR1 mitochondrial fission regulator 1 -3.67013
FGFR4 fibroblast growth factor receptor 4 -3.53944
ARID5B AT rich interactive domain 5B (MRF1-like) -3.30249
ZMIZ1 zinc finger, MIZ-type containing 1 -3.09278
EIF5 eukaryotic translation initiation factor 5 -2.9318
EGF epidermal growth factor -2.72457
BIRC2 baculoviral IAP repeat containing 2 -2.61484
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.33201
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) -2.22115
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.16681
RBM15B RNA binding motif protein 15B -2.11393
ITGB1BP1 integrin beta 1 binding protein 1 -2.10666
TRAPPC6A trafficking protein particle complex 6A -2.06241
XPO7 exportin 7 -2.02824
VEGFB vascular endothelial growth factor B -2.02509