CRCGN012_HEPG2_24H:C01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description eugenol 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN012_HEPG2_24H:C01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 7.47155
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 7.3921
MYLK myosin light chain kinase 5.95907
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.66285
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 5.31987
LYN LYN proto-oncogene, Src family tyrosine kinase 3.94273
PPARG peroxisome proliferator-activated receptor gamma 3.72964
GPER1 G protein-coupled estrogen receptor 1 3.68329
PRR15L proline rich 15-like 3.35592
CHN1 chimerin 1 3.24592
LCN2 lipocalin 2 3.23566
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.1175
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.11357
EPHB2 EPH receptor B2 3.06603
SMAD3 SMAD family member 3 3.04099
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.94037
RRAGA Ras-related GTP binding A 2.91813
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.88906
TLR4 toll-like receptor 4 2.71411
ADRB2 adrenoceptor beta 2, surface 2.69619
SATB1 SATB homeobox 1 2.6348
ADGRE5 adhesion G protein-coupled receptor E5 2.44408
ANO1 anoctamin 1, calcium activated chloride channel 2.4272
RPL39L ribosomal protein L39-like 2.42365
BAD BCL2-associated agonist of cell death 2.37209
CCL2 chemokine (C-C motif) ligand 2 2.36226
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.35152
DYNLT3 dynein, light chain, Tctex-type 3 2.31716
UGDH UDP-glucose 6-dehydrogenase 2.28018
RBM47 RNA binding motif protein 47 2.23441
SH3D19 SH3 domain containing 19 2.17114
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.14347
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.13808
TXNRD1 thioredoxin reductase 1 2.11747
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.04154

decreased expression

Symbol Name Standardized Value
GOLT1B golgi transport 1B -6.22918
CCNB2 cyclin B2 -4.3632
ISOC1 isochorismatase domain containing 1 -4.118
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.91472
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.77444
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.60146
FBXL12 F-box and leucine-rich repeat protein 12 -3.58539
RAI14 retinoic acid induced 14 -3.35886
SNX11 sorting nexin 11 -3.28624
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.05194
PDLIM1 PDZ and LIM domain 1 -2.98035
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.63873
ZNF586 zinc finger protein 586 -2.59005
GNAS GNAS complex locus -2.49232
TCTN1 tectonic family member 1 -2.4116
OXA1L oxidase (cytochrome c) assembly 1-like -2.38191
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.3598
CDC20 cell division cycle 20 -2.30013
SLC35B1 solute carrier family 35, member B1 -2.25362
TM9SF3 transmembrane 9 superfamily member 3 -2.23552
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 -2.215
PEX26 peroxisomal biogenesis factor 26 -2.12001
TMEM97 transmembrane protein 97 -2.09575
DDIT4 DNA-damage-inducible transcript 4 -2.05205