CRCGN012_HEPG2_24H:C02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description eugenol 19.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN012_HEPG2_24H:C02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CSK c-src tyrosine kinase 6.86808
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.15645
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.91403
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.87999
PPARG peroxisome proliferator-activated receptor gamma 4.57388
CIAO3 cytosolic iron-sulfur assembly component 3 4.3742
ANO1 anoctamin 1, calcium activated chloride channel 3.71997
DYNLT3 dynein, light chain, Tctex-type 3 3.59325
FPGS folylpolyglutamate synthase 3.22591
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.1763
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.08653
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.91969
MOK MOK protein kinase 2.82097
MAP7 microtubule-associated protein 7 2.79674
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.6187
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.55392
ALDOC aldolase C, fructose-bisphosphate 2.54569
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.51634
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.5153
NENF neudesin neurotrophic factor 2.41277
PEX13 peroxisomal biogenesis factor 13 2.40245
ASCC3 activating signal cointegrator 1 complex subunit 3 2.31758
HSPA1A heat shock 70kDa protein 1A 2.24109
GPER1 G protein-coupled estrogen receptor 1 2.23146
SFTPB surfactant protein B 2.22047
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.13226
C4BPB complement component 4 binding protein, beta 2.12134
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.10858
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.09971
KIF14 kinesin family member 14 2.09092
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 2.07978
NDFIP1 Nedd4 family interacting protein 1 2.05534

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.79481
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.15332
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.14687
PCNA proliferating cell nuclear antigen -6.14038
EGF epidermal growth factor -4.44451
COG2 component of oligomeric golgi complex 2 -4.23638
CD320 CD320 molecule -4.19624
TSPAN4 tetraspanin 4 -4.14587
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.00992
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.94984
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -3.94816
CGRRF1 cell growth regulator with ring finger domain 1 -3.87768
ZDHHC6 zinc finger, DHHC-type containing 6 -3.41375
UGDH UDP-glucose 6-dehydrogenase -3.38548
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.28893
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.03524
SCAND1 SCAN domain containing 1 -2.8117
SLC35F2 solute carrier family 35, member F2 -2.74011
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.73678
PTK2 protein tyrosine kinase 2 -2.65308
MAPK13 mitogen-activated protein kinase 13 -2.56606
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.54357
MTERF3 mitochondrial transcription termination factor 3 -2.50086
PRSS3 protease, serine, 3 -2.48713
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.39765
CLTB clathrin, light chain B -2.39094
NRIP1 nuclear receptor interacting protein 1 -2.35361
PLS1 plastin 1 -2.34729
DERA deoxyribose-phosphate aldolase (putative) -2.31249
FGFR4 fibroblast growth factor receptor 4 -2.26575
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -2.24248
NFE2L3 nuclear factor, erythroid 2-like 3 -2.21823
DBF4B DBF4 zinc finger B -2.18771
WDR83OS WD repeat domain 83 opposite strand -2.17937
GULP1 GULP, engulfment adaptor PTB domain containing 1 -2.17102
CBX7 chromobox homolog 7 -2.16461
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.15565
PDLIM1 PDZ and LIM domain 1 -2.12546
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.11587
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -2.11182
FAM200C family with sequence similarity 200 member C -2.11
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 -2.05994
SESN1 sestrin 1 -2.04298
SYK spleen tyrosine kinase -2.02593
STN1 STN1 subunit of CST complex -2.01558