CRCGN012_HEPG2_24H:C06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description eugenol 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

71 genes differentially expressed following the CRCGN012_HEPG2_24H:C06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
E2F2 E2F transcription factor 2 7.06912
CCL2 chemokine (C-C motif) ligand 2 5.95815
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.67636
CBR3 carbonyl reductase 3 3.88571
SOCS2 suppressor of cytokine signaling 2 3.81108
EAPP E2F-associated phosphoprotein 3.56343
INTS3 integrator complex subunit 3 3.5403
CCNF cyclin F 3.45105
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.35845
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.25821
CIAO3 cytosolic iron-sulfur assembly component 3 3.18934
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 3.14804
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 3.12844
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 3.04487
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.9596
PRR15L proline rich 15-like 2.94997
RSAD2 radical S-adenosyl methionine domain containing 2 2.84687
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.80829
ADGRE5 adhesion G protein-coupled receptor E5 2.78561
MX1 MX dynamin-like GTPase 1 2.7376
PEX11A peroxisomal biogenesis factor 11 alpha 2.73451
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.72115
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.71193
PPARG peroxisome proliferator-activated receptor gamma 2.69765
IFI6 interferon, alpha-inducible protein 6 2.64559
TIMP2 TIMP metallopeptidase inhibitor 2 2.58002
RIGI RNA sensor RIG-I 2.56871
CSK c-src tyrosine kinase 2.56134
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.54679
DHDDS dehydrodolichyl diphosphate synthase 2.50042
ISG15 ISG15 ubiquitin-like modifier 2.48977
UBQLN2 ubiquilin 2 2.44611
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.3922
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.37072
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.31418
RXYLT1 ribitol xylosyltransferase 1 2.27833
ADAM10 ADAM metallopeptidase domain 10 2.25063
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.24119
CXCL2 chemokine (C-X-C motif) ligand 2 2.24035
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 2.23198
HDGFL3 HDGF like 3 2.22905
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.22723
GSTZ1 glutathione S-transferase zeta 1 2.10658
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 2.07815
GTPBP2 GTP binding protein 2 2.0552
MAP7 microtubule-associated protein 7 2.02917

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -7.48781
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.97543
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.94889
PCNA proliferating cell nuclear antigen -4.84654
CCNB1 cyclin B1 -4.70639
FGFR4 fibroblast growth factor receptor 4 -4.55748
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.83206
CRELD2 cysteine-rich with EGF-like domains 2 -3.48163
CD320 CD320 molecule -3.43723
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.41696
LDHD lactate dehydrogenase D -3.38136
TNS2 tensin 2 -2.9329
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.83517
ADI1 acireductone dioxygenase 1 -2.74233
YME1L1 YME1-like 1 ATPase -2.66048
ISOC1 isochorismatase domain containing 1 -2.61714
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.47019
GSTM2 glutathione S-transferase mu 2 (muscle) -2.45266
CCNB2 cyclin B2 -2.42736
NGRN neugrin, neurite outgrowth associated -2.40182
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.26266
EIF5 eukaryotic translation initiation factor 5 -2.21701
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.1428
SCAND1 SCAN domain containing 1 -2.02033