CRCGN012_HEPG2_24H:C07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pentachlorophenol 39.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

246 genes differentially expressed following the CRCGN012_HEPG2_24H:C07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 9.41158
TIMP2 TIMP metallopeptidase inhibitor 2 8.76954
VAT1 vesicle amine transport 1 7.74045
PLS1 plastin 1 7.62221
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 6.69772
SQOR sulfide quinone oxidoreductase 6.65287
MVP major vault protein 6.63962
E2F2 E2F transcription factor 2 6.63898
TXNRD1 thioredoxin reductase 1 6.28439
PPARG peroxisome proliferator-activated receptor gamma 5.93632
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 5.89105
ABHD4 abhydrolase domain containing 4 5.76997
RAP1GAP RAP1 GTPase activating protein 5.57147
CNPY3 canopy FGF signaling regulator 3 5.16657
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.06696
KIFBP kinesin family binding protein 4.94099
LCN2 lipocalin 2 4.78461
ZFP36 ZFP36 ring finger protein 4.74407
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.40363
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 4.33152
SMAD3 SMAD family member 3 4.26624
MINDY1 MINDY lysine 48 deubiquitinase 1 4.05359
CYTH1 cytohesin 1 4.02868
SRC SRC proto-oncogene, non-receptor tyrosine kinase 4.002
INPP1 inositol polyphosphate-1-phosphatase 3.9557
UGDH UDP-glucose 6-dehydrogenase 3.78719
LPGAT1 lysophosphatidylglycerol acyltransferase 1 3.67817
STAP2 signal transducing adaptor family member 2 3.63026
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.43501
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.4231
ANO1 anoctamin 1, calcium activated chloride channel 3.32571
IDE insulin-degrading enzyme 3.29759
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.29579
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.28507
CHN1 chimerin 1 3.27197
DUSP6 dual specificity phosphatase 6 3.26894
PRR15L proline rich 15-like 3.21403
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.20329
STX4 syntaxin 4 3.18252
ACOT9 acyl-CoA thioesterase 9 3.14485
SPDEF SAM pointed domain containing ETS transcription factor 3.13781
SQSTM1 sequestosome 1 3.12541
GLRX glutaredoxin (thioltransferase) 3.06272
RSU1 Ras suppressor protein 1 3.06038
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.0589
STK10 serine/threonine kinase 10 3.04743
MSRA methionine sulfoxide reductase A 3.00175
KDM3A lysine (K)-specific demethylase 3A 2.99758
SYNE2 spectrin repeat containing, nuclear envelope 2 2.96437
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.95012
HMOX1 heme oxygenase 1 2.92697
CGRRF1 cell growth regulator with ring finger domain 1 2.9177
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.89221
ANO10 anoctamin 10 2.85481
CRYZ crystallin, zeta (quinone reductase) 2.8317
PTK2 protein tyrosine kinase 2 2.81009
CCDC86 coiled-coil domain containing 86 2.80942
NANOS3 nanos homolog 3 (Drosophila) 2.78857
AXIN1 axin 1 2.77311
DYNLT3 dynein, light chain, Tctex-type 3 2.75545
NOSIP nitric oxide synthase interacting protein 2.74403
FOSL1 FOS-like antigen 1 2.71862
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.65978
VGLL4 vestigial-like family member 4 2.64796
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.62019
PRKCD protein kinase C, delta 2.6116
GPER1 G protein-coupled estrogen receptor 1 2.59539
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.59481
ATF3 activating transcription factor 3 2.59289
LPAR2 lysophosphatidic acid receptor 2 2.5874
RPP38 ribonuclease P/MRP 38kDa subunit 2.56037
RALB v-ral simian leukemia viral oncogene homolog B 2.55091
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.54216
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.53906
IFI35 interferon-induced protein 35 2.47812
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.4702
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.44294
IGFBP3 insulin-like growth factor binding protein 3 2.44061
BAG3 BCL2-associated athanogene 3 2.4289
BMP4 bone morphogenetic protein 4 2.38831
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.37612
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.36045
YIPF3 Yip1 domain family, member 3 2.32432
FAM50A family with sequence similarity 50, member A 2.3086
ETFB electron-transfer-flavoprotein, beta polypeptide 2.29148
DOCK1 dedicator of cytokinesis 1 2.29107
MAD2L1BP MAD2L1 binding protein 2.29009
BYSL bystin-like 2.28569
HMG20B high mobility group 20B 2.25336
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 2.23827
DSG2 desmoglein 2 2.2274
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 2.21509
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.1864
TLK2 tousled-like kinase 2 2.16514
CDK7 cyclin-dependent kinase 7 2.16205
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 2.12688
CCP110 centriolar coiled coil protein 110kDa 2.12018
SKIC2 SKI2 subunit of superkiller complex 2.11072
GRB10 growth factor receptor-bound protein 10 2.09988
SH3GLB1 SH3-domain GRB2-like endophilin B1 2.09053
H2BC12 H2B clustered histone 12 2.08872
ANXA9 annexin A9 2.07721
CISD1 CDGSH iron sulfur domain 1 2.06234
SUN2 Sad1 and UNC84 domain containing 2 2.05245
DENND5A DENN/MADD domain containing 5A 2.01145
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 2.00911
PDE8A phosphodiesterase 8A 2.00904
SLC44A4 solute carrier family 44, member 4 2.00447
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 2.00297
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.00023

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -9.49079
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.91715
CCNB1 cyclin B1 -6.71706
SLC35F2 solute carrier family 35, member F2 -6.62191
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -6.53751
CDC20 cell division cycle 20 -6.4869
PSRC1 proline/serine-rich coiled-coil 1 -6.25656
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.21155
CDK1 cyclin-dependent kinase 1 -6.08055
MELK maternal embryonic leucine zipper kinase -5.84384
CCNA2 cyclin A2 -5.74165
ZW10 zw10 kinetochore protein -5.69062
PLK1 polo-like kinase 1 -5.52125
ARID5B AT rich interactive domain 5B (MRF1-like) -5.34085
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -5.17914
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.87882
UBE2C ubiquitin-conjugating enzyme E2C -4.8372
AURKB aurora kinase B -4.76947
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.42041
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.40436
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.35363
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.22892
HAT1 histone acetyltransferase 1 -4.21547
TCTN1 tectonic family member 1 -4.18014
POLR1A polymerase (RNA) I polypeptide A, 194kDa -4.07042
TMEM97 transmembrane protein 97 -3.97282
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.95615
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.90411
GLOD4 glyoxalase domain containing 4 -3.89419
ZDHHC6 zinc finger, DHHC-type containing 6 -3.80299
BIRC5 baculoviral IAP repeat containing 5 -3.73815
HSPB1 heat shock 27kDa protein 1 -3.71967
CCNB2 cyclin B2 -3.66688
STMN1 stathmin 1 -3.61535
TOP2A topoisomerase (DNA) II alpha 170kDa -3.59348
PECR peroxisomal trans-2-enoyl-CoA reductase -3.54835
NUP85 nucleoporin 85kDa -3.4709
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.42085
ADI1 acireductone dioxygenase 1 -3.35892
CHEK2 checkpoint kinase 2 -3.31835
FIRRM FIGNL1 interacting regulator of recombination and mitosis -3.11218
BIRC2 baculoviral IAP repeat containing 2 -3.07242
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.07238
NFIL3 nuclear factor, interleukin 3 regulated -2.99268
MIS18A MIS18 kinetochore protein A -2.92779
NUP93 nucleoporin 93kDa -2.91104
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.87371
AURKA aurora kinase A -2.86828
MAP7 microtubule-associated protein 7 -2.85903
LDHD lactate dehydrogenase D -2.82851
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.82826
RPIA ribose 5-phosphate isomerase A -2.77476
TCERG1 transcription elongation regulator 1 -2.76185
NCAPG2 non-SMC condensin II complex, subunit G2 -2.75704
OXA1L oxidase (cytochrome c) assembly 1-like -2.74585
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.68107
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.66889
SMC4 structural maintenance of chromosomes 4 -2.61948
TRIB3 tribbles pseudokinase 3 -2.60389
GNAS GNAS complex locus -2.57974
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.55431
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.54123
TERT telomerase reverse transcriptase -2.51244
RFC3 replication factor C (activator 1) 3, 38kDa -2.50807
ASF1B anti-silencing function 1B histone chaperone -2.4893
MRPS33 mitochondrial ribosomal protein S33 -2.47787
CDCA8 cell division cycle associated 8 -2.47635
DSCC1 DNA replication and sister chromatid cohesion 1 -2.46804
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.46681
RFC4 replication factor C (activator 1) 4, 37kDa -2.46051
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -2.45386
ENOPH1 enolase-phosphatase 1 -2.42505
LAGE3 L antigen family, member 3 -2.41919
CTCF CCCTC-binding factor (zinc finger protein) -2.40896
CDK4 cyclin-dependent kinase 4 -2.39564
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.38849
MOCS2 molybdenum cofactor synthesis 2 -2.3828
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.37626
PARP2 poly (ADP-ribose) polymerase 2 -2.37348
PARP1 poly (ADP-ribose) polymerase 1 -2.36022
FOXM1 forkhead box M1 -2.34634
HMGA2 high mobility group AT-hook 2 -2.34605
CCNE1 cyclin E1 -2.34132
KRT34 keratin 34, type I -2.33346
S100A8 S100 calcium binding protein A8 -2.33003
TTK TTK protein kinase -2.3281
KIF15 kinesin family member 15 -2.30929
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -2.29999
SPRR1B small proline-rich protein 1B -2.29448
RPL34 ribosomal protein L34 -2.29323
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.29074
USP1 ubiquitin specific peptidase 1 -2.28526
CENPE centromere protein E, 312kDa -2.27302
C2CD5 C2 calcium-dependent domain containing 5 -2.26
SSPN sarcospan -2.25763
CCDC15 coiled-coil domain containing 15 -2.2448
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.23977
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.22339
NCAPD2 non-SMC condensin I complex, subunit D2 -2.22076
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.2203
HMGN2 high mobility group nucleosomal binding domain 2 -2.21225
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.20618
NT5DC2 5'-nucleotidase domain containing 2 -2.19693
OAZ2 ornithine decarboxylase antizyme 2 -2.19677
TRMT5 tRNA methyltransferase 5 -2.18492
SPDL1 spindle apparatus coiled-coil protein 1 -2.17811
KRT5 keratin 5, type II -2.17277
RNASE7 ribonuclease, RNase A family, 7 -2.15504
GTF2A2 general transcription factor IIA, 2, 12kDa -2.15458
ZNF83 zinc finger protein 83 -2.1533
IL24 interleukin 24 -2.15081
PEG10 paternally expressed 10 -2.14322
SOAT2 sterol O-acyltransferase 2 -2.13713
TMED9 transmembrane emp24 protein transport domain containing 9 -2.1093
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.1049
TMEM186 transmembrane protein 186 -2.10429
UNC50 unc-50 homolog (C. elegans) -2.101
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.09924
KRT6A keratin 6A, type II -2.09749
MSMO1 methylsterol monooxygenase 1 -2.09032
FBXO5 F-box protein 5 -2.08582
RYR3 ryanodine receptor 3 -2.08338
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.07814
TRIP13 thyroid hormone receptor interactor 13 -2.0573
FGFR4 fibroblast growth factor receptor 4 -2.05641
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -2.05622
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.04122
RUBCNL rubicon like autophagy enhancer -2.03681
CDC25A cell division cycle 25A -2.03114
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.02503
APOA1 apolipoprotein A-I -2.02479
LBR lamin B receptor -2.02441
TBC1D31 TBC1 domain family, member 31 -2.01776
MLEC malectin -2.01471
BLMH bleomycin hydrolase -2.01439
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.00683