CRCGN012_HEPG2_24H:C08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pentachlorophenol 19.7 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

176 genes differentially expressed following the CRCGN012_HEPG2_24H:C08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 7.99023
CSK c-src tyrosine kinase 6.01872
VAT1 vesicle amine transport 1 5.6585
OXCT1 3-oxoacid CoA transferase 1 5.46728
HOXA10 homeobox A10 5.22746
PLS1 plastin 1 4.97747
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.95735
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.89684
ADGRE5 adhesion G protein-coupled receptor E5 4.83312
SQOR sulfide quinone oxidoreductase 4.81568
MYLK myosin light chain kinase 4.79786
CCL2 chemokine (C-C motif) ligand 2 4.77105
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.48414
TXNRD1 thioredoxin reductase 1 4.44135
NANOS3 nanos homolog 3 (Drosophila) 4.39739
CGRRF1 cell growth regulator with ring finger domain 1 3.78917
TIMP2 TIMP metallopeptidase inhibitor 2 3.76864
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.74573
ZFP36 ZFP36 ring finger protein 3.7022
RAP1GAP RAP1 GTPase activating protein 3.61912
C2CD2 C2 calcium-dependent domain containing 2 3.49949
BZW2 basic leucine zipper and W2 domains 2 3.48194
IL1B interleukin 1, beta 3.47028
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.39128
PRKCH protein kinase C, eta 3.33496
GHR growth hormone receptor 3.2851
MVP major vault protein 3.28041
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.20023
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 3.09583
UGDH UDP-glucose 6-dehydrogenase 3.09368
RRAGA Ras-related GTP binding A 3.05352
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.04858
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.03733
LCN2 lipocalin 2 3.01328
ADRB2 adrenoceptor beta 2, surface 2.95465
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.92224
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.90346
DYNLT3 dynein, light chain, Tctex-type 3 2.88654
MOK MOK protein kinase 2.85692
DUSP6 dual specificity phosphatase 6 2.82311
STAP2 signal transducing adaptor family member 2 2.81497
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.79748
SCRN1 secernin 1 2.79544
LAGE3 L antigen family, member 3 2.78385
PPARG peroxisome proliferator-activated receptor gamma 2.78168
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.75827
EDN1 endothelin 1 2.74615
ARID4B AT rich interactive domain 4B (RBP1-like) 2.73565
SNAP25 synaptosomal-associated protein, 25kDa 2.72166
FOXO4 forkhead box O4 2.71848
DNTT DNA nucleotidylexotransferase 2.7167
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.68029
MCM3 minichromosome maintenance complex component 3 2.63408
CEMIP2 cell migration inducing hyaluronidase 2 2.57974
ABHD17B abhydrolase domain containing 17B 2.56559
SMAD3 SMAD family member 3 2.56533
CDPF1 cysteine-rich, DPF motif domain containing 1 2.48644
ABHD6 abhydrolase domain containing 6 2.48346
LCT lactase 2.43084
TBC1D10C TBC1 domain family, member 10C 2.42667
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.41913
CIAO3 cytosolic iron-sulfur assembly component 3 2.41845
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.41298
BLNK B-cell linker 2.37136
PARP1 poly (ADP-ribose) polymerase 1 2.3709
GRHPR glyoxylate reductase/hydroxypyruvate reductase 2.36343
LOXL1 lysyl oxidase-like 1 2.36172
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.34792
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.34673
GSTZ1 glutathione S-transferase zeta 1 2.32974
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.32934
KDM3A lysine (K)-specific demethylase 3A 2.2908
BCL2 B-cell CLL/lymphoma 2 2.27171
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.26254
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.23906
PIAS3 protein inhibitor of activated STAT, 3 2.22991
BAHCC1 BAH domain and coiled-coil containing 1 2.22937
PROSER1 proline and serine rich 1 2.21675
MAEA macrophage erythroblast attacher 2.17137
MCF2L MCF.2 cell line derived transforming sequence-like 2.15218
SCARB1 scavenger receptor class B, member 1 2.14781
CCP110 centriolar coiled coil protein 110kDa 2.13606
RSU1 Ras suppressor protein 1 2.13172
SPDEF SAM pointed domain containing ETS transcription factor 2.1284
BUB1B-PAK6 BUB1B-PAK6 readthrough 2.11828
STC1 stanniocalcin 1 2.10249
KLHL9 kelch-like family member 9 2.09848
KCTD14 potassium channel tetramerization domain containing 14 2.09501
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.08738
CD248 CD248 molecule, endosialin 2.08722
ADM adrenomedullin 2.08257
C2CD2L C2CD2-like 2.08224
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.07879
CES1 carboxylesterase 1 2.05969
PVALB parvalbumin 2.05316
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.04958
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 2.0411
GLB1L galactosidase, beta 1-like 2.02426
ATF4 activating transcription factor 4 2.02383
LPAR2 lysophosphatidic acid receptor 2 2.01446
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.00823
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 2.0036
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.00274

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -8.80827
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -6.9437
GTPBP8 GTP-binding protein 8 (putative) -6.78768
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.9718
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.9353
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.54911
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.37571
TLCD3A TLC domain containing 3A -4.27507
CRELD2 cysteine-rich with EGF-like domains 2 -3.86132
ISOC1 isochorismatase domain containing 1 -3.81819
BPHL biphenyl hydrolase-like (serine hydrolase) -3.81648
LDHD lactate dehydrogenase D -3.51021
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.45781
FGFR4 fibroblast growth factor receptor 4 -3.44362
CCNB2 cyclin B2 -3.35337
CDK1 cyclin-dependent kinase 1 -3.29975
ADI1 acireductone dioxygenase 1 -3.27579
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.23179
FASTKD5 FAST kinase domains 5 -3.11923
PSRC1 proline/serine-rich coiled-coil 1 -3.11038
TCTN1 tectonic family member 1 -3.05487
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.05436
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.9737
DPH2 DPH2 homolog (S. cerevisiae) -2.93925
ALDOC aldolase C, fructose-bisphosphate -2.84857
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.76938
STMN1 stathmin 1 -2.75637
YME1L1 YME1-like 1 ATPase -2.71125
GALE UDP-galactose-4-epimerase -2.70155
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.58772
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.52946
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.47655
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 -2.40767
RPIA ribose 5-phosphate isomerase A -2.39993
UBE2C ubiquitin-conjugating enzyme E2C -2.37007
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.33473
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -2.3282
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -2.30293
SPDL1 spindle apparatus coiled-coil protein 1 -2.26292
SESN1 sestrin 1 -2.25599
HYOU1 hypoxia up-regulated 1 -2.25319
ECHDC2 enoyl CoA hydratase domain containing 2 -2.25253
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.21896
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.21561
MLEC malectin -2.19515
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.18093
DVL1 dishevelled segment polarity protein 1 -2.1769
CLCC1 chloride channel CLIC-like 1 -2.17204
CDC20 cell division cycle 20 -2.16534
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.16435
MYH6 myosin, heavy chain 6, cardiac muscle, alpha -2.16308
SLN sarcolipin -2.16306
ACOT9 acyl-CoA thioesterase 9 -2.15729
TERT telomerase reverse transcriptase -2.15491
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.14323
BIRC2 baculoviral IAP repeat containing 2 -2.14039
PEX11A peroxisomal biogenesis factor 11 alpha -2.13729
CKM creatine kinase, muscle -2.13535
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.11561
MSMO1 methylsterol monooxygenase 1 -2.11374
EXOSC4 exosome component 4 -2.06475
MYOM1 myomesin 1 -2.05966
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -2.05102
TMOD1 tropomodulin 1 -2.04601
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) -2.04447
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.0279
AUNIP aurora kinase A and ninein interacting protein -2.01778
NUP85 nucleoporin 85kDa -2.01396
TMEM186 transmembrane protein 186 -2.00549
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -2.00521
SEC61G Sec61 gamma subunit -2.00268
ZNF571 zinc finger protein 571 -2.00204
ICAM3 intercellular adhesion molecule 3 -2.0013