CRCGN012_HEPG2_24H:C09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pentachlorophenol 9.85 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN012_HEPG2_24H:C09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 7.41535
PNKP polynucleotide kinase 3'-phosphatase 4.39215
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.13912
DYNLT3 dynein, light chain, Tctex-type 3 4.1272
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.71965
VAT1 vesicle amine transport 1 3.63865
EPHA3 EPH receptor A3 3.14982
RRAGA Ras-related GTP binding A 3.08335
DENND2D DENN/MADD domain containing 2D 3.05352
TXNRD1 thioredoxin reductase 1 3.03025
SATB1 SATB homeobox 1 2.96085
STK10 serine/threonine kinase 10 2.94466
CCNF cyclin F 2.88885
MVP major vault protein 2.76155
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.73408
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.66515
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.63492
PLSCR1 phospholipid scramblase 1 2.54898
JADE2 jade family PHD finger 2 2.5224
HOXA10 homeobox A10 2.4808
GPATCH8 G patch domain containing 8 2.39821
ANXA6 annexin A6 2.32713
BAD BCL2-associated agonist of cell death 2.32679
ANO1 anoctamin 1, calcium activated chloride channel 2.31186
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.25382
HOMER2 homer scaffolding protein 2 2.22748
ETFB electron-transfer-flavoprotein, beta polypeptide 2.22088
UBQLN2 ubiquilin 2 2.21376
CCL2 chemokine (C-C motif) ligand 2 2.19706
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.18679
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.16363
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.15363
ADGRE5 adhesion G protein-coupled receptor E5 2.11627
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.09247
CNPY3 canopy FGF signaling regulator 3 2.07628
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 2.03339
KDM3A lysine (K)-specific demethylase 3A 2.03049
PPARG peroxisome proliferator-activated receptor gamma 2.01708

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.1764
SLC35F2 solute carrier family 35, member F2 -7.06992
CCNB2 cyclin B2 -6.23226
MRPS2 mitochondrial ribosomal protein S2 -6.19857
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -5.22996
ZMIZ1 zinc finger, MIZ-type containing 1 -5.04481
CD320 CD320 molecule -4.56471
CRELD2 cysteine-rich with EGF-like domains 2 -4.3814
EGF epidermal growth factor -4.0648
CDC20 cell division cycle 20 -4.0207
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.8244
ARID5B AT rich interactive domain 5B (MRF1-like) -3.43751
PEG10 paternally expressed 10 -3.43145
TRIB3 tribbles pseudokinase 3 -3.35367
ZNF586 zinc finger protein 586 -3.28011
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.22178
DSG2 desmoglein 2 -3.19619
IFRD2 interferon-related developmental regulator 2 -3.16036
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.69478
NGRN neugrin, neurite outgrowth associated -2.5379
GOLT1B golgi transport 1B -2.49867
SNX11 sorting nexin 11 -2.24526
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.2428
GRB7 growth factor receptor-bound protein 7 -2.2366
USP6NL USP6 N-terminal like -2.18519
LAP3 leucine aminopeptidase 3 -2.16731
SPAG4 sperm associated antigen 4 -2.09014
PECR peroxisomal trans-2-enoyl-CoA reductase -2.08993
PCNA proliferating cell nuclear antigen -2.08761
TMEM115 transmembrane protein 115 -2.08469