CRCGN012_HEPG2_24H:C13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-methyl?aniline) 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN012_HEPG2_24H:C13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 7.14621
NOTCH1 notch 1 7.05457
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.72753
LCN2 lipocalin 2 4.36687
TIAM1 T-cell lymphoma invasion and metastasis 1 4.19198
CSK c-src tyrosine kinase 4.18911
CHMP6 charged multivesicular body protein 6 4.01308
RPP38 ribonuclease P/MRP 38kDa subunit 3.81022
BACE2 beta-site APP-cleaving enzyme 2 3.79092
SNAP25 synaptosomal-associated protein, 25kDa 3.52112
DENND2D DENN/MADD domain containing 2D 3.22119
LYN LYN proto-oncogene, Src family tyrosine kinase 3.02414
CBR3 carbonyl reductase 3 3.005
MYLK myosin light chain kinase 2.9773
CCL2 chemokine (C-C motif) ligand 2 2.93745
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.86279
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.82308
EPHB2 EPH receptor B2 2.75896
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.73575
GSTZ1 glutathione S-transferase zeta 1 2.62021
ABHD4 abhydrolase domain containing 4 2.59659
E2F2 E2F transcription factor 2 2.53614
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.53137
C2CD2 C2 calcium-dependent domain containing 2 2.44578
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.42299
GPATCH8 G patch domain containing 8 2.34142
PRKCH protein kinase C, eta 2.30423
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.30341
EVL Enah/Vasp-like 2.25938
BAX BCL2-associated X protein 2.25116
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.24572
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.18038
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.08912
PAQR6 progestin and adipoQ receptor family member VI 2.03973
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.01401

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -4.83223
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.12313
LDHD lactate dehydrogenase D -3.83459
ZMIZ1 zinc finger, MIZ-type containing 1 -3.72825
MAPK13 mitogen-activated protein kinase 13 -3.53198
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.48664
PSRC1 proline/serine-rich coiled-coil 1 -3.40997
PRPF4 pre-mRNA processing factor 4 -3.17185
HAT1 histone acetyltransferase 1 -3.16882
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.11752
WASHC4 WASH complex subunit 4 -2.7446
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.66372
BLCAP bladder cancer associated protein -2.47305
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.38189
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.37876
SLC35F2 solute carrier family 35, member F2 -2.30076
GNAS GNAS complex locus -2.28911
YME1L1 YME1-like 1 ATPase -2.25196
EXT1 exostosin glycosyltransferase 1 -2.13406
IER3 immediate early response 3 -2.07847
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.05367
EGF epidermal growth factor -2.04708