| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 4,4'-methylene-bis(2-methyl?aniline) 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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60 genes differentially expressed following the CRCGN012_HEPG2_24H:C14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CHMP6 | charged multivesicular body protein 6 | 7.14755 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 5.43106 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 4.69464 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 4.55455 |
| CYCS | cytochrome c, somatic | 4.53515 |
| MYLK | myosin light chain kinase | 4.50539 |
| NOTCH1 | notch 1 | 3.97789 |
| ATP11B | ATPase, class VI, type 11B | 3.97704 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | 3.56141 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.36112 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.12233 |
| HOXA10 | homeobox A10 | 3.11629 |
| IDE | insulin-degrading enzyme | 2.97149 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 2.96848 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.84057 |
| VGLL4 | vestigial-like family member 4 | 2.69818 |
| AMDHD2 | amidohydrolase domain containing 2 | 2.69651 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 2.52465 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 2.47185 |
| RPL39L | ribosomal protein L39-like | 2.35734 |
| PRR5 | proline rich 5 (renal) | 2.35207 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 2.3343 |
| PMM1 | phosphomannomutase 1 | 2.25123 |
| PLSCR3 | phospholipid scramblase 3 | 2.24412 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | 2.20337 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 2.17618 |
| ZNF629 | zinc finger protein 629 | 2.1662 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 2.1198 |
| PRR15L | proline rich 15-like | 2.11338 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2.06398 |
| CCNH | cyclin H | 2.06083 |
| SCYL3 | SCY1-like 3 (S. cerevisiae) | 2.05825 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB2 | cyclin B2 | -5.55784 |
| CCNB1 | cyclin B1 | -5.55004 |
| TRIB3 | tribbles pseudokinase 3 | -4.79179 |
| GNAS | GNAS complex locus | -4.59376 |
| KDM3A | lysine (K)-specific demethylase 3A | -4.45088 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.81373 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -3.51347 |
| ADI1 | acireductone dioxygenase 1 | -3.38996 |
| PRPF4 | pre-mRNA processing factor 4 | -3.16296 |
| DNM1L | dynamin 1-like | -3.03263 |
| MRPS2 | mitochondrial ribosomal protein S2 | -2.75224 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -2.67487 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.54761 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -2.52758 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.49045 |
| VAT1 | vesicle amine transport 1 | -2.37735 |
| YME1L1 | YME1-like 1 ATPase | -2.29307 |
| SPIB | Spi-B transcription factor (Spi-1/PU.1 related) | -2.21505 |
| DPYD | dihydropyrimidine dehydrogenase | -2.15509 |
| TFEB | transcription factor EB | -2.14724 |
| VDAC1 | voltage-dependent anion channel 1 | -2.14377 |
| AICDA | activation-induced cytidine deaminase | -2.12671 |
| KRT86 | keratin 86, type II | -2.10276 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | -2.08871 |
| VIM | vimentin | -2.08854 |
| SAMHD1 | SAM domain and HD domain 1 | -2.08255 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -2.08014 |
| BIRC2 | baculoviral IAP repeat containing 2 | -2.01518 |
