| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 4,4'-methylene-bis(2-methyl?aniline) 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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60 genes differentially expressed following the CRCGN012_HEPG2_24H:C15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NOTCH1 | notch 1 | 8.00371 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 6.14141 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 4.60313 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 4.58675 |
| CHMP6 | charged multivesicular body protein 6 | 4.29636 |
| KLHL21 | kelch-like family member 21 | 4.25244 |
| BZW2 | basic leucine zipper and W2 domains 2 | 4.20713 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.17282 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | 4.03975 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 4.00318 |
| EVL | Enah/Vasp-like | 3.9194 |
| CSK | c-src tyrosine kinase | 3.72531 |
| RAB21 | RAB21, member RAS oncogene family | 3.54256 |
| MICALL1 | MICAL-like 1 | 3.4603 |
| HDGFL3 | HDGF like 3 | 3.09722 |
| CDC45 | cell division cycle 45 | 3.01529 |
| CEP57 | centrosomal protein 57kDa | 2.93194 |
| ZNF589 | zinc finger protein 589 | 2.75063 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.71595 |
| MAP7 | microtubule-associated protein 7 | 2.61838 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | 2.5135 |
| SIRT3 | sirtuin 3 | 2.35192 |
| PLSCR3 | phospholipid scramblase 3 | 2.33724 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.16923 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.12506 |
| CHN1 | chimerin 1 | 2.05641 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.02145 |
| SGPP1 | sphingosine-1-phosphate phosphatase 1 | 2.01703 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -8.22583 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -7.53258 |
| PLK1 | polo-like kinase 1 | -4.62587 |
| MRPS16 | mitochondrial ribosomal protein S16 | -4.39513 |
| THAP11 | THAP domain containing 11 | -4.39315 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -4.16273 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -4.14371 |
| VAT1 | vesicle amine transport 1 | -4.13908 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -4.08304 |
| ZNF586 | zinc finger protein 586 | -4.03771 |
| ADI1 | acireductone dioxygenase 1 | -4.01924 |
| LDHD | lactate dehydrogenase D | -3.89109 |
| SLC35F2 | solute carrier family 35, member F2 | -3.44273 |
| TRIB3 | tribbles pseudokinase 3 | -3.3691 |
| GNAS | GNAS complex locus | -3.14109 |
| CCNB2 | cyclin B2 | -3.03215 |
| PRPF4 | pre-mRNA processing factor 4 | -2.91577 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.90506 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.87745 |
| CHMP4B | charged multivesicular body protein 4B | -2.71238 |
| ZNF623 | zinc finger protein 623 | -2.48921 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.37114 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.36074 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -2.22189 |
| FBXO34 | F-box protein 34 | -2.15049 |
| UNC5C | unc-5 homolog C (C. elegans) | -2.12567 |
| NIBAN1 | niban apoptosis regulator 1 | -2.10258 |
| PAM16 | presequence translocase-associated motor 16 homolog (S. cerevisiae) | -2.06843 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -2.03268 |
| MAB21L1 | mab-21-like 1 (C. elegans) | -2.0187 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.01719 |
| GHITM | growth hormone inducible transmembrane protein | -2.0073 |
