CRCGN012_HEPG2_24H:C16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-methyl?aniline) 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN012_HEPG2_24H:C16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 10.0
ATP11B ATPase, class VI, type 11B 6.90001
GPER1 G protein-coupled estrogen receptor 1 4.99724
CBR3 carbonyl reductase 3 4.14551
HOXA10 homeobox A10 3.9732
RPL39L ribosomal protein L39-like 3.84054
GARRE1 granule associated Rac and RHOG effector 1 3.7125
BZW2 basic leucine zipper and W2 domains 2 3.69542
SNAP25 synaptosomal-associated protein, 25kDa 3.51202
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.19744
CSK c-src tyrosine kinase 3.12273
CHMP6 charged multivesicular body protein 6 2.97321
ADRB2 adrenoceptor beta 2, surface 2.9398
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.7816
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.76432
DIPK1A divergent protein kinase domain 1A 2.74324
ABHD6 abhydrolase domain containing 6 2.71112
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.6304
JADE2 jade family PHD finger 2 2.50269
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.43754
MAMLD1 mastermind-like domain containing 1 2.42242
H2BC12 H2B clustered histone 12 2.3317
GSTZ1 glutathione S-transferase zeta 1 2.31935
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.29503
STIMATE STIM activating enhancer 2.26932
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.25531
FPGS folylpolyglutamate synthase 2.01584
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.0125
TEX10 testis expressed 10 2.00887

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -9.17616
ZNF586 zinc finger protein 586 -3.96926
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.65973
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.96103
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.91699
RNF167 ring finger protein 167 -2.7995
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.64855
RGS2 regulator of G-protein signaling 2 -2.55324
GDF15 growth differentiation factor 15 -2.50717
TRIB3 tribbles pseudokinase 3 -2.49584
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.39437
ACAA1 acetyl-CoA acyltransferase 1 -2.38528
VDAC1 voltage-dependent anion channel 1 -2.26154
CCNB2 cyclin B2 -2.25308
LDHD lactate dehydrogenase D -2.22294
NRIP1 nuclear receptor interacting protein 1 -2.16464
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.01377