CRCGN012_HEPG2_24H:C17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-methyl?aniline) 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

80 genes differentially expressed following the CRCGN012_HEPG2_24H:C17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 7.35297
CHN1 chimerin 1 5.16287
PNKP polynucleotide kinase 3'-phosphatase 4.80118
PRR15L proline rich 15-like 4.72143
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.6059
MAMLD1 mastermind-like domain containing 1 4.51817
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.41079
PLSCR1 phospholipid scramblase 1 4.20462
TIAM1 T-cell lymphoma invasion and metastasis 1 4.08928
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.93396
ADRB2 adrenoceptor beta 2, surface 3.90169
CSK c-src tyrosine kinase 3.79398
LCN2 lipocalin 2 3.76728
CAPN1 calpain 1, (mu/I) large subunit 3.7014
BACE2 beta-site APP-cleaving enzyme 2 3.61798
RPL39L ribosomal protein L39-like 3.57978
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.5426
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.45338
MYLK myosin light chain kinase 3.43915
BTK Bruton agammaglobulinemia tyrosine kinase 3.36704
E2F2 E2F transcription factor 2 3.29379
BZW2 basic leucine zipper and W2 domains 2 3.25707
CHMP6 charged multivesicular body protein 6 3.21125
EPHB2 EPH receptor B2 3.15821
STXBP2 syntaxin binding protein 2 3.14791
ADGRE5 adhesion G protein-coupled receptor E5 3.01811
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.99879
HOXA10 homeobox A10 2.99343
C2CD2 C2 calcium-dependent domain containing 2 2.812
CARMIL1 capping protein regulator and myosin 1 linker 1 2.74927
STIMATE STIM activating enhancer 2.56715
JADE2 jade family PHD finger 2 2.53159
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.48719
TLR4 toll-like receptor 4 2.37203
AGO2 argonaute RISC catalytic component 2 2.28567
TGFB3 transforming growth factor, beta 3 2.26008
GADD45A growth arrest and DNA-damage-inducible, alpha 2.23911
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.22548
SHB Src homology 2 domain containing adaptor protein B 2.1975
CXCL13 chemokine (C-X-C motif) ligand 13 2.10257
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.06788
CD4 CD4 molecule 2.06539
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.04711
LMO7 LIM domain 7 2.02701
ADAM10 ADAM metallopeptidase domain 10 2.00741

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.42875
CAB39 calcium binding protein 39 -5.10348
COG7 component of oligomeric golgi complex 7 -3.77654
ETFB electron-transfer-flavoprotein, beta polypeptide -3.69624
PCNA proliferating cell nuclear antigen -3.5758
MRPS2 mitochondrial ribosomal protein S2 -3.56315
FBXL12 F-box and leucine-rich repeat protein 12 -3.52471
ADI1 acireductone dioxygenase 1 -3.47352
PEG10 paternally expressed 10 -3.43593
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.19396
CDC20 cell division cycle 20 -3.18501
GOLT1B golgi transport 1B -3.12669
NVL nuclear VCP-like -3.10609
KDM3A lysine (K)-specific demethylase 3A -3.06731
MAPK13 mitogen-activated protein kinase 13 -3.02591
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.02084
ZMIZ1 zinc finger, MIZ-type containing 1 -2.9222
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.90948
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.72312
GET1 guided entry of tail-anchored proteins factor 1 -2.71504
GNAS GNAS complex locus -2.6847
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.62198
LOC124907782 dual specificity protein phosphatase 22 -2.59985
GDF15 growth differentiation factor 15 -2.52068
NGRN neugrin, neurite outgrowth associated -2.5023
FGFR4 fibroblast growth factor receptor 4 -2.47873
DNM1L dynamin 1-like -2.47657
FOS FBJ murine osteosarcoma viral oncogene homolog -2.38468
NRIP1 nuclear receptor interacting protein 1 -2.2835
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 -2.22041
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.21676
YME1L1 YME1-like 1 ATPase -2.2018
STAMBP STAM binding protein -2.14707
C5 complement component 5 -2.06398
BIRC2 baculoviral IAP repeat containing 2 -2.06353