CRCGN012_HEPG2_24H:C18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-methyl?aniline) 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

241 genes differentially expressed following the CRCGN012_HEPG2_24H:C18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 10.0
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 7.75793
KCNK1 potassium channel, two pore domain subfamily K, member 1 6.02614
PPARG peroxisome proliferator-activated receptor gamma 5.39715
NOTCH1 notch 1 5.33686
STIMATE STIM activating enhancer 5.31785
EPHB2 EPH receptor B2 4.3367
LCN2 lipocalin 2 4.12454
CIAO3 cytosolic iron-sulfur assembly component 3 4.0381
BLMH bleomycin hydrolase 3.73322
BACE2 beta-site APP-cleaving enzyme 2 3.6258
CSK c-src tyrosine kinase 3.53108
CYCS cytochrome c, somatic 3.5132
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.47014
ARL4C ADP-ribosylation factor-like 4C 3.39833
SYNE2 spectrin repeat containing, nuclear envelope 2 3.3447
MINDY1 MINDY lysine 48 deubiquitinase 1 3.31077
FAIM Fas apoptotic inhibitory molecule 3.28578
CDPF1 cysteine-rich, DPF motif domain containing 1 3.21764
STAP2 signal transducing adaptor family member 2 3.19867
CCNP cyclin P 3.12188
LYN LYN proto-oncogene, Src family tyrosine kinase 3.12103
SFTPB surfactant protein B 3.02215
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.01855
ZNF747 zinc finger protein 747 2.97433
CTSL cathepsin L 2.94116
SQOR sulfide quinone oxidoreductase 2.92481
SLC22A14 solute carrier family 22, member 14 2.91145
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.85366
CCNA1 cyclin A1 2.84984
TBC1D31 TBC1 domain family, member 31 2.79681
CEP70 centrosomal protein 70kDa 2.7506
PNKP polynucleotide kinase 3'-phosphatase 2.71489
EPHA3 EPH receptor A3 2.6973
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.68452
SFXN1 sideroflexin 1 2.65022
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.64786
MSRA methionine sulfoxide reductase A 2.64454
CCNE2 cyclin E2 2.642
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.60598
CRLF3 cytokine receptor-like factor 3 2.59196
MALT1 MALT1 paracaspase 2.55821
UBE2O ubiquitin-conjugating enzyme E2O 2.55369
ACOT13 acyl-CoA thioesterase 13 2.54048
CCNJL cyclin J-like 2.53727
UBQLN2 ubiquilin 2 2.5307
CHN1 chimerin 1 2.51927
LPAR2 lysophosphatidic acid receptor 2 2.5123
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 2.48646
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4 2.47813
PRR15L proline rich 15-like 2.45907
CDX1 caudal type homeobox 1 2.44537
GSTZ1 glutathione S-transferase zeta 1 2.42793
NSD1 nuclear receptor binding SET domain protein 1 2.38293
HSPA1A heat shock 70kDa protein 1A 2.37699
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.37284
DENND2D DENN/MADD domain containing 2D 2.37191
CNTFR ciliary neurotrophic factor receptor 2.36319
ISOC1 isochorismatase domain containing 1 2.36249
TEX10 testis expressed 10 2.34944
FANCC Fanconi anemia, complementation group C 2.34681
NLRP4 NLR family, pyrin domain containing 4 2.33776
SIRT3 sirtuin 3 2.33353
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.32683
FANCE Fanconi anemia, complementation group E 2.30911
TXLNA taxilin alpha 2.2828
MAST2 microtubule associated serine/threonine kinase 2 2.28255
PIAS3 protein inhibitor of activated STAT, 3 2.28218
GRWD1 glutamate-rich WD repeat containing 1 2.28122
HOOK2 hook microtubule-tethering protein 2 2.27052
TM9SF2 transmembrane 9 superfamily member 2 2.26922
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.25313
IGFBP3 insulin-like growth factor binding protein 3 2.2517
OR5I1 olfactory receptor, family 5, subfamily I, member 1 2.23036
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.22743
CYB561 cytochrome b561 2.20758
FAM76A family with sequence similarity 76, member A 2.20733
CASC3 cancer susceptibility candidate 3 2.20608
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.19139
LARP7 La ribonucleoprotein domain family, member 7 2.19062
CNN2 calponin 2 2.18878
BCL7B B-cell CLL/lymphoma 7B 2.1879
CDK20 cyclin-dependent kinase 20 2.17941
NHERF4 NHERF family PDZ scaffold protein 4 2.16621
CNGA1 cyclic nucleotide gated channel alpha 1 2.16589
REPS2 RALBP1 associated Eps domain containing 2 2.16577
PZP pregnancy-zone protein 2.14654
AFG3L2 AFG3-like AAA ATPase 2 2.14284
CTR9 CTR9, Paf1/RNA polymerase II complex component 2.13249
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.12875
MAGEA2B melanoma antigen family A2B 2.12453
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.1154
XYLT2 xylosyltransferase II 2.11519
CD40LG CD40 ligand 2.10256
FXYD1 FXYD domain containing ion transport regulator 1 2.09316
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.08975
PCBP4 poly(rC) binding protein 4 2.08549
CDC25B cell division cycle 25B 2.0738
NOSIP nitric oxide synthase interacting protein 2.0715
CENPT centromere protein T 2.07042
KDM5A lysine (K)-specific demethylase 5A 2.06844
AARS1 alanyl-tRNA synthetase 1 2.06477
ZNF552 zinc finger protein 552 2.06332
FGF6 fibroblast growth factor 6 2.06148
SSTR4 somatostatin receptor 4 2.05938
DPF3 D4, zinc and double PHD fingers, family 3 2.05382
PVALB parvalbumin 2.05259
SH3GL3 SH3-domain GRB2-like 3 2.04516
SSBP3 single stranded DNA binding protein 3 2.03059
PYDC1 PYD (pyrin domain) containing 1 2.0277
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.02407
STUM stum, mechanosensory transduction mediator homolog 2.01921
C1GALT1C1 C1GALT1-specific chaperone 1 2.01018
GDF9 growth differentiation factor 9 2.00099

decreased expression

Symbol Name Standardized Value
CCDC86 coiled-coil domain containing 86 -7.61288
PEG10 paternally expressed 10 -5.52419
RNPS1 RNA binding protein S1, serine-rich domain -5.38943
CCNB2 cyclin B2 -5.32024
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.91671
PTPRK protein tyrosine phosphatase, receptor type, K -4.74804
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.60498
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.50038
FAT1 FAT atypical cadherin 1 -4.21492
COG7 component of oligomeric golgi complex 7 -4.17138
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.0922
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.0011
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.94234
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.85492
TSPAN6 tetraspanin 6 -3.79962
INTS3 integrator complex subunit 3 -3.7509
IER3 immediate early response 3 -3.74432
TUBB6 tubulin, beta 6 class V -3.71564
CDC20 cell division cycle 20 -3.68128
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.65585
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.61099
MRPS16 mitochondrial ribosomal protein S16 -3.5983
GDF15 growth differentiation factor 15 -3.57801
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.57399
LAP3 leucine aminopeptidase 3 -3.51651
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.51536
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -3.49814
POLR1A polymerase (RNA) I polypeptide A, 194kDa -3.46346
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.45665
HYOU1 hypoxia up-regulated 1 -3.43581
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.38797
PMM2 phosphomannomutase 2 -3.37698
EIF5 eukaryotic translation initiation factor 5 -3.34888
UGDH UDP-glucose 6-dehydrogenase -3.34344
MRPS2 mitochondrial ribosomal protein S2 -3.32589
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -3.29633
RFC2 replication factor C (activator 1) 2, 40kDa -3.28916
CORO1A coronin, actin binding protein, 1A -3.24011
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 -3.2366
SNCA synuclein, alpha (non A4 component of amyloid precursor) -3.13384
TRIB3 tribbles pseudokinase 3 -3.09236
ICE1 interactor of little elongation complex ELL subunit 1 -3.08352
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.05026
MELK maternal embryonic leucine zipper kinase -3.04688
SLC35F2 solute carrier family 35, member F2 -2.98674
ILK integrin-linked kinase -2.97669
ZNF586 zinc finger protein 586 -2.97592
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.96818
PUS1 pseudouridylate synthase 1 -2.95138
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -2.93594
KLHL9 kelch-like family member 9 -2.90476
CGRRF1 cell growth regulator with ring finger domain 1 -2.7663
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.75399
METTL22 methyltransferase like 22 -2.69493
ACLY ATP citrate lyase -2.68759
DNM1L dynamin 1-like -2.67867
BYSL bystin-like -2.65612
BZW2 basic leucine zipper and W2 domains 2 -2.64046
CHEK1 checkpoint kinase 1 -2.61592
NME6 NME/NM23 nucleoside diphosphate kinase 6 -2.56506
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 -2.51588
WDR7 WD repeat domain 7 -2.50758
STOML2 stomatin (EPB72)-like 2 -2.49969
PPP1R15A protein phosphatase 1, regulatory subunit 15A -2.49029
UBE2C ubiquitin-conjugating enzyme E2C -2.4737
MAPK13 mitogen-activated protein kinase 13 -2.45658
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.44788
ADGRG1 adhesion G protein-coupled receptor G1 -2.43805
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -2.40908
APEH acylaminoacyl-peptide hydrolase -2.38687
USP6NL USP6 N-terminal like -2.3717
C2CD5 C2 calcium-dependent domain containing 5 -2.36699
TRIP4 thyroid hormone receptor interactor 4 -2.36094
MLH1 mutL homolog 1 -2.30915
GATAD1 GATA zinc finger domain containing 1 -2.30741
SGCE sarcoglycan, epsilon -2.30071
MVP major vault protein -2.29532
KRT8 keratin 8, type II -2.29116
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -2.27687
PDLIM1 PDZ and LIM domain 1 -2.26902
MARCHF8 membrane associated ring-CH-type finger 8 -2.26022
PRPF19 pre-mRNA processing factor 19 -2.2487
NUP42 nucleoporin 42 -2.24266
UCN urocortin -2.24204
FAM193A family with sequence similarity 193, member A -2.23327
ZNF394 zinc finger protein 394 -2.22583
ZNF263 zinc finger protein 263 -2.19331
MAP3K7CL MAP3K7 C-terminal like -2.18882
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.18624
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.186
WDR73 WD repeat domain 73 -2.18504
GPR143 G protein-coupled receptor 143 -2.18416
EIF3B eukaryotic translation initiation factor 3, subunit B -2.17025
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -2.16836
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -2.16487
SNRPC small nuclear ribonucleoprotein polypeptide C -2.16054
TLCD3A TLC domain containing 3A -2.15796
THOC6 THO complex 6 -2.15774
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -2.15448
CLUH clustered mitochondria (cluA/CLU1) homolog -2.15159
MAP2K5 mitogen-activated protein kinase kinase 5 -2.14517
HSPA2 heat shock 70kDa protein 2 -2.13631
DGUOK deoxyguanosine kinase -2.1333
GDE1 glycerophosphodiester phosphodiesterase 1 -2.12906
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.12125
EGF epidermal growth factor -2.11991
SOWAHC sosondowah ankyrin repeat domain family member C -2.11031
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit -2.11007
SASH1 SAM and SH3 domain containing 1 -2.11006
PIH1D1 PIH1 domain containing 1 -2.10962
HIKESHI heat shock protein nuclear import factor hikeshi -2.10808
CYREN cell cycle regulator of NHEJ -2.09825
RAB38 RAB38, member RAS oncogene family -2.09646
EXT1 exostosin glycosyltransferase 1 -2.08909
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 -2.07414
MOB3B MOB kinase activator 3B -2.07281
NOX4 NADPH oxidase 4 -2.07062
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -2.07013
GPATCH3 G patch domain containing 3 -2.06562
ZNF74 zinc finger protein 74 -2.06272
RCC1L RCC1 like -2.05617
YOD1 YOD1 deubiquitinase -2.04839
ATG101 autophagy related 101 -2.04687
LY6H lymphocyte antigen 6 complex, locus H -2.03632
SH3GL2 SH3-domain GRB2-like 2 -2.03017
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -2.01904
IRF9 interferon regulatory factor 9 -2.0172