| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone 20.5 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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92 genes differentially expressed following the CRCGN012_HEPG2_24H:D02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 6.90255 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 6.22621 |
| CSK | c-src tyrosine kinase | 6.04002 |
| CHN1 | chimerin 1 | 5.38739 |
| EPHA3 | EPH receptor A3 | 4.30307 |
| RPL39L | ribosomal protein L39-like | 4.09831 |
| ADRB2 | adrenoceptor beta 2, surface | 3.91519 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.83179 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.75646 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.69019 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 3.59981 |
| MVP | major vault protein | 3.57779 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.57558 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 3.43047 |
| FCHO1 | FCH domain only 1 | 3.3444 |
| ABHD4 | abhydrolase domain containing 4 | 3.25056 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 3.18205 |
| INPP1 | inositol polyphosphate-1-phosphatase | 3.10647 |
| E2F2 | E2F transcription factor 2 | 3.08514 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.01626 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 3.00292 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 2.90925 |
| STK10 | serine/threonine kinase 10 | 2.82781 |
| TXNRD1 | thioredoxin reductase 1 | 2.78232 |
| UBQLN2 | ubiquilin 2 | 2.75976 |
| MYLK | myosin light chain kinase | 2.71057 |
| ZNF536 | zinc finger protein 536 | 2.70151 |
| CCL2 | chemokine (C-C motif) ligand 2 | 2.69391 |
| CDK6 | cyclin-dependent kinase 6 | 2.5784 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 2.55477 |
| TPD52L2 | tumor protein D52-like 2 | 2.51526 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.50075 |
| SQSTM1 | sequestosome 1 | 2.42662 |
| DUSP6 | dual specificity phosphatase 6 | 2.41853 |
| BLCAP | bladder cancer associated protein | 2.38332 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 2.32952 |
| BZW2 | basic leucine zipper and W2 domains 2 | 2.22049 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | 2.19778 |
| TDRD1 | tudor domain containing 1 | 2.15657 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.09254 |
| STEAP4 | STEAP family member 4 | 2.08095 |
| CBR1 | carbonyl reductase 1 | 2.06372 |
| UFM1 | ubiquitin-fold modifier 1 | 2.03965 |
| CYCS | cytochrome c, somatic | 2.01997 |
| NMU | neuromedin U | 2.00281 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NGRN | neugrin, neurite outgrowth associated | -5.40988 |
| ISOC1 | isochorismatase domain containing 1 | -4.71053 |
| AURKB | aurora kinase B | -4.47517 |
| TCTN1 | tectonic family member 1 | -4.14657 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -4.05163 |
| CCNB2 | cyclin B2 | -3.88277 |
| EIF5 | eukaryotic translation initiation factor 5 | -3.66463 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -3.53017 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -3.35515 |
| ADI1 | acireductone dioxygenase 1 | -3.31333 |
| USP6NL | USP6 N-terminal like | -3.29448 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -3.08122 |
| VDAC1 | voltage-dependent anion channel 1 | -3.00205 |
| PLK1 | polo-like kinase 1 | -2.91484 |
| ZW10 | zw10 kinetochore protein | -2.90421 |
| SOAT2 | sterol O-acyltransferase 2 | -2.87854 |
| CDK1 | cyclin-dependent kinase 1 | -2.87615 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -2.86051 |
| MELK | maternal embryonic leucine zipper kinase | -2.85076 |
| COG2 | component of oligomeric golgi complex 2 | -2.66955 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.58942 |
| ZNF586 | zinc finger protein 586 | -2.50186 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -2.41765 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -2.39901 |
| COPS7A | COP9 signalosome subunit 7A | -2.36429 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.36355 |
| HADH | hydroxyacyl-CoA dehydrogenase | -2.35467 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | -2.34321 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.33066 |
| CAB39 | calcium binding protein 39 | -2.33046 |
| CCNA2 | cyclin A2 | -2.31892 |
| TROAP | trophinin associated protein | -2.27638 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.27053 |
| LBR | lamin B receptor | -2.25297 |
| CDC25B | cell division cycle 25B | -2.25031 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -2.24551 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -2.24501 |
| KIF14 | kinesin family member 14 | -2.20718 |
| MYL9 | myosin, light chain 9, regulatory | -2.18522 |
| SPAG4 | sperm associated antigen 4 | -2.18432 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.16731 |
| DNASE1L2 | deoxyribonuclease I-like 2 | -2.14687 |
| PCNA | proliferating cell nuclear antigen | -2.1296 |
| NUP85 | nucleoporin 85kDa | -2.07847 |
| DIO3 | deiodinase, iodothyronine, type III | -2.07157 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.01658 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -2.00121 |
