CRCGN012_HEPG2_24H:D03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone 10.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

82 genes differentially expressed following the CRCGN012_HEPG2_24H:D03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 9.74326
GPER1 G protein-coupled estrogen receptor 1 4.58963
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.45496
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.86982
ADRB2 adrenoceptor beta 2, surface 3.8565
KLHL21 kelch-like family member 21 3.66702
DHDDS dehydrodolichyl diphosphate synthase 3.62108
CSK c-src tyrosine kinase 3.58496
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.55123
ADGRE5 adhesion G protein-coupled receptor E5 3.4562
TAC4 tachykinin 4 (hemokinin) 3.44064
RPL39L ribosomal protein L39-like 3.43721
NFIL3 nuclear factor, interleukin 3 regulated 3.27441
PNKP polynucleotide kinase 3'-phosphatase 3.20069
MYLK myosin light chain kinase 3.01624
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.94947
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.92021
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.88856
NOTCH1 notch 1 2.7665
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.68264
STIMATE STIM activating enhancer 2.6813
ATP11B ATPase, class VI, type 11B 2.66763
ZW10 zw10 kinetochore protein 2.6623
GATA3 GATA binding protein 3 2.60276
LPAR2 lysophosphatidic acid receptor 2 2.59865
EPN2 epsin 2 2.56975
CCL2 chemokine (C-C motif) ligand 2 2.5125
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.49966
PCDHB11 protocadherin beta 11 2.43325
MELK maternal embryonic leucine zipper kinase 2.36714
TMEM43 transmembrane protein 43 2.33454
LOC122526780 uncharacterized LOC122526780 2.31832
GPATCH8 G patch domain containing 8 2.31328
CDC45 cell division cycle 45 2.31065
TIAM1 T-cell lymphoma invasion and metastasis 1 2.29578
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.29282
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.29006
TCEAL4 transcription elongation factor A (SII)-like 4 2.28573
EPHA3 EPH receptor A3 2.22969
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.20961
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.20528
LCN2 lipocalin 2 2.18193
SFTPB surfactant protein B 2.17202
VGLL4 vestigial-like family member 4 2.13796
UFM1 ubiquitin-fold modifier 1 2.13697
CYCS cytochrome c, somatic 2.12593
HSPA1A heat shock 70kDa protein 1A 2.04914
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.04607
JADE2 jade family PHD finger 2 2.0442
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 2.02044

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.54269
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.11926
PCNA proliferating cell nuclear antigen -5.35508
CDC20 cell division cycle 20 -4.16324
NUP93 nucleoporin 93kDa -4.07237
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.60564
RGS2 regulator of G-protein signaling 2 -3.47827
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.37249
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.23051
MRPS2 mitochondrial ribosomal protein S2 -3.17848
TCTN1 tectonic family member 1 -3.17817
DNM1L dynamin 1-like -3.12451
COG2 component of oligomeric golgi complex 2 -3.06414
TM9SF3 transmembrane 9 superfamily member 3 -3.02779
LAP3 leucine aminopeptidase 3 -2.90226
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.8112
TRIB3 tribbles pseudokinase 3 -2.79174
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.53114
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.49562
OXA1L oxidase (cytochrome c) assembly 1-like -2.38439
CTSD cathepsin D -2.35206
RFC2 replication factor C (activator 1) 2, 40kDa -2.31836
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.1453
VDAC1 voltage-dependent anion channel 1 -2.12173
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.10472
USP6NL USP6 N-terminal like -2.0794
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.07622
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.04486
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -2.04363
SCAND1 SCAN domain containing 1 -2.01041
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.00709
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) -2.00256