CRCGN012_HEPG2_24H:D04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone 5.13 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN012_HEPG2_24H:D04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.43182
LAGE3 L antigen family, member 3 3.97433
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.89657
CHMP6 charged multivesicular body protein 6 3.8034
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.4821
PRR15L proline rich 15-like 3.40154
CSK c-src tyrosine kinase 3.3132
ATP11B ATPase, class VI, type 11B 3.17487
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.13766
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.97448
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.78582
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.60437
TIAM1 T-cell lymphoma invasion and metastasis 1 2.57258
LCN2 lipocalin 2 2.49611
RPL39L ribosomal protein L39-like 2.4891
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.43743
ANO1 anoctamin 1, calcium activated chloride channel 2.39864
PCNA proliferating cell nuclear antigen 2.21702
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.17724
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.06556
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.01773
AHCTF1 AT hook containing transcription factor 1 2.01081

decreased expression

Symbol Name Standardized Value
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.74154
OXA1L oxidase (cytochrome c) assembly 1-like -3.47771
LDHD lactate dehydrogenase D -3.34685
EIF5 eukaryotic translation initiation factor 5 -3.25704
SCAND1 SCAN domain containing 1 -2.69053
MAPK13 mitogen-activated protein kinase 13 -2.49541
TM9SF3 transmembrane 9 superfamily member 3 -2.42138
FASTKD5 FAST kinase domains 5 -2.18424
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.10958
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.00429