| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone 2.56 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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74 genes differentially expressed following the CRCGN012_HEPG2_24H:D05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.3709 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.7043 |
| CCL2 | chemokine (C-C motif) ligand 2 | 4.66275 |
| RPL39L | ribosomal protein L39-like | 4.6204 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 4.59075 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.51465 |
| RRAGA | Ras-related GTP binding A | 4.0953 |
| MOK | MOK protein kinase | 4.0026 |
| NMU | neuromedin U | 3.75385 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 3.71515 |
| CSK | c-src tyrosine kinase | 3.6602 |
| EVL | Enah/Vasp-like | 3.2325 |
| LCN2 | lipocalin 2 | 3.20415 |
| PLSCR1 | phospholipid scramblase 1 | 3.1927 |
| KIF14 | kinesin family member 14 | 2.8468 |
| CCNF | cyclin F | 2.82592 |
| CEBPZ | CCAAT/enhancer binding protein (C/EBP), zeta | 2.81375 |
| PCNA | proliferating cell nuclear antigen | 2.66145 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.63053 |
| CYCS | cytochrome c, somatic | 2.52335 |
| IFI16 | interferon, gamma-inducible protein 16 | 2.47323 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.45082 |
| SORBS3 | sorbin and SH3 domain containing 3 | 2.24285 |
| FSD1 | fibronectin type III and SPRY domain containing 1 | 2.232 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 2.22725 |
| HSPA8 | heat shock 70kDa protein 8 | 2.14883 |
| DONSON | downstream neighbor of SON | 2.0968 |
| DYNLL1 | dynein, light chain, LC8-type 1 | 2.09625 |
| CCNH | cyclin H | 2.08095 |
| SLC25A24 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 | 2.0637 |
| ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide | 2.04818 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | 2.02565 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 2.0199 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | 2.0131 |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta | 2.0077 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -4.76685 |
| CDC20 | cell division cycle 20 | -4.6684 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.36715 |
| CCNB2 | cyclin B2 | -4.19295 |
| ZNF586 | zinc finger protein 586 | -4.18245 |
| CD320 | CD320 molecule | -3.95755 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -3.77155 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -3.7528 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -3.40838 |
| CAB39 | calcium binding protein 39 | -3.0714 |
| BLCAP | bladder cancer associated protein | -2.9409 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -2.78695 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | -2.5114 |
| PRPF4 | pre-mRNA processing factor 4 | -2.38932 |
| TCTN1 | tectonic family member 1 | -2.3291 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -2.32765 |
| TECR | trans-2,3-enoyl-CoA reductase | -2.2984 |
| PNPLA4 | patatin-like phospholipase domain containing 4 | -2.28767 |
| MAP7 | microtubule-associated protein 7 | -2.27317 |
| CHAD | chondroadherin | -2.25065 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | -2.23265 |
| FBXO2 | F-box protein 2 | -2.18635 |
| LHPP | phospholysine phosphohistidine inorganic pyrophosphate phosphatase | -2.18345 |
| ELAC2 | elaC ribonuclease Z 2 | -2.1772 |
| OSR2 | odd-skipped related transciption factor 2 | -2.17435 |
| AKAP3 | A kinase (PRKA) anchor protein 3 | -2.15845 |
| TCEA2 | transcription elongation factor A (SII), 2 | -2.1499 |
| SOX3 | SRY (sex determining region Y)-box 3 | -2.14895 |
| PPEF1 | protein phosphatase, EF-hand calcium binding domain 1 | -2.12 |
| ACADSB | acyl-CoA dehydrogenase, short/branched chain | -2.09935 |
| ACSM3 | acyl-CoA synthetase medium-chain family member 3 | -2.09923 |
| MYF6 | myogenic factor 6 (herculin) | -2.058 |
| SEMG2 | semenogelin II | -2.05165 |
| ATXN7L1 | ataxin 7-like 1 | -2.037 |
| ADAM20 | ADAM metallopeptidase domain 20 | -2.02755 |
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | -2.02035 |
| OR5I1 | olfactory receptor, family 5, subfamily I, member 1 | -2.0158 |
| BRS3 | bombesin-like receptor 3 | -2.0155 |
| TAS2R4 | taste receptor, type 2, member 4 | -2.0092 |
