CRCGN012_HEPG2_24H:D06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone 1.28 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN012_HEPG2_24H:D06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IDE insulin-degrading enzyme 5.10609
TIAM1 T-cell lymphoma invasion and metastasis 1 5.02931
RPL39L ribosomal protein L39-like 4.95879
UBQLN2 ubiquilin 2 4.89825
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.61679
GSTZ1 glutathione S-transferase zeta 1 4.56882
PFKL phosphofructokinase, liver 4.33387
SNAP25 synaptosomal-associated protein, 25kDa 3.89712
LOC122526780 uncharacterized LOC122526780 3.67756
ADRB2 adrenoceptor beta 2, surface 3.16074
MOK MOK protein kinase 2.80209
MCM3 minichromosome maintenance complex component 3 2.78384
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.6286
LCN2 lipocalin 2 2.57394
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.51265
SOCS2 suppressor of cytokine signaling 2 2.50367
CSK c-src tyrosine kinase 2.4477
PRR15L proline rich 15-like 2.41621
GATD3 glutamine amidotransferase class 1 domain containing 3 2.37643
GPATCH8 G patch domain containing 8 2.3646
STXBP2 syntaxin binding protein 2 2.1166
TBP TATA box binding protein 2.10095
E2F2 E2F transcription factor 2 2.04954
KIF20A kinesin family member 20A 2.03543

decreased expression

Symbol Name Standardized Value
FAIM Fas apoptotic inhibitory molecule -5.14457
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.5829
OXA1L oxidase (cytochrome c) assembly 1-like -3.26771
SSBP2 single-stranded DNA binding protein 2 -2.86667
CD58 CD58 molecule -2.82209
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.7004
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.63061
GNAS GNAS complex locus -2.50887
GOLT1B golgi transport 1B -2.46109
CCNB1 cyclin B1 -2.35847
NRIP1 nuclear receptor interacting protein 1 -2.19207
IFI16 interferon, gamma-inducible protein 16 -2.15512
EIF5 eukaryotic translation initiation factor 5 -2.05346