CRCGN012_HEPG2_24H:D10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hexachlorocyclopentadiene 5.03 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

253 genes differentially expressed following the CRCGN012_HEPG2_24H:D10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 10.0
ABHD4 abhydrolase domain containing 4 8.97818
HSPA1A heat shock 70kDa protein 1A 7.62189
SQOR sulfide quinone oxidoreductase 7.17348
LCN2 lipocalin 2 6.55657
NUCB2 nucleobindin 2 6.27727
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 5.96823
SQSTM1 sequestosome 1 5.60852
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 5.12778
MVP major vault protein 4.51259
NOSIP nitric oxide synthase interacting protein 4.46377
TXNRD1 thioredoxin reductase 1 4.23794
TIMP2 TIMP metallopeptidase inhibitor 2 4.06884
EGR1 early growth response 1 3.99991
GPATCH8 G patch domain containing 8 3.98754
CBR1 carbonyl reductase 1 3.94349
GOLT1B golgi transport 1B 3.91944
TUBB6 tubulin, beta 6 class V 3.77455
E2F2 E2F transcription factor 2 3.66614
CIAO3 cytosolic iron-sulfur assembly component 3 3.64394
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.58319
BAG3 BCL2-associated athanogene 3 3.5381
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.50447
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.48199
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.43123
EGF epidermal growth factor 3.39997
DYNLT3 dynein, light chain, Tctex-type 3 3.38191
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.35269
MEF2C myocyte enhancer factor 2C 3.33017
PPARG peroxisome proliferator-activated receptor gamma 3.26421
VGLL4 vestigial-like family member 4 3.16664
NPDC1 neural proliferation, differentiation and control, 1 3.15382
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.13925
SLC35B1 solute carrier family 35, member B1 3.12812
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.12477
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.12469
ALAS1 5'-aminolevulinate synthase 1 3.1098
CTSD cathepsin D 3.10553
JUN jun proto-oncogene 3.09158
BLMH bleomycin hydrolase 3.05514
CGRRF1 cell growth regulator with ring finger domain 1 3.04051
GLRX glutaredoxin (thioltransferase) 3.03546
ZFP36 ZFP36 ring finger protein 2.96981
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.9507
EMC7 ER membrane protein complex subunit 7 2.87519
IER3 immediate early response 3 2.86221
CSK c-src tyrosine kinase 2.85769
SNAP25 synaptosomal-associated protein, 25kDa 2.84412
INPP1 inositol polyphosphate-1-phosphatase 2.81452
CCDC92 coiled-coil domain containing 92 2.74896
NGRN neugrin, neurite outgrowth associated 2.74491
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.74113
CCP110 centriolar coiled coil protein 110kDa 2.73808
PRKCQ protein kinase C, theta 2.68956
IL37 interleukin 37 2.68192
SCPEP1 serine carboxypeptidase 1 2.64941
TRIB1 tribbles pseudokinase 1 2.63927
STX4 syntaxin 4 2.61703
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.60539
ARL4C ADP-ribosylation factor-like 4C 2.59386
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.58805
TERF2IP telomeric repeat binding factor 2, interacting protein 2.54586
UFM1 ubiquitin-fold modifier 1 2.54496
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.53707
HTRA1 HtrA serine peptidase 1 2.53664
BBC3 BCL2 binding component 3 2.53007
TBPL1 TBP-like 1 2.52384
IGHMBP2 immunoglobulin mu binding protein 2 2.50386
TMEM50A transmembrane protein 50A 2.49809
CHMP6 charged multivesicular body protein 6 2.49788
CARMIL1 capping protein regulator and myosin 1 linker 1 2.48726
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.47934
RNF25 ring finger protein 25 2.45723
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.45093
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.45087
NUPR1 nuclear protein, transcriptional regulator, 1 2.4214
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.41402
LOC128125814 uncharacterized LOC128125814 2.38673
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 2.35759
EMC3 ER membrane protein complex subunit 3 2.35752
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 2.35429
ATF6 activating transcription factor 6 2.34942
AIRIM AFG2 interacting ribosome maturation factor 2.34807
BIRC2 baculoviral IAP repeat containing 2 2.34578
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.34007
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.33153
SDF2 stromal cell-derived factor 2 2.33027
GABARAPL1 GABA(A) receptor-associated protein like 1 2.30944
GADD45A growth arrest and DNA-damage-inducible, alpha 2.29233
APP amyloid beta (A4) precursor protein 2.29139
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 2.25944
TM9SF2 transmembrane 9 superfamily member 2 2.24893
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 2.24271
CNPY3 canopy FGF signaling regulator 3 2.24172
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.24145
LRP10 low density lipoprotein receptor-related protein 10 2.23246
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.21176
ATG4A autophagy related 4A, cysteine peptidase 2.1878
FABP2 fatty acid binding protein 2, intestinal 2.18278
WDTC1 WD and tetratricopeptide repeats 1 2.1827
MRPS22 mitochondrial ribosomal protein S22 2.17617
IFRD1 interferon-related developmental regulator 1 2.17476
JMJD6 jumonji domain containing 6 2.17193
TMCO1 transmembrane and coiled-coil domains 1 2.16085
ODR4 odr-4 GPCR localization factor homolog 2.16015
TMED9 transmembrane emp24 protein transport domain containing 9 2.15689
IL26 interleukin 26 2.15028
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 2.14565
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.14207
DENND2D DENN/MADD domain containing 2D 2.13785
PNKP polynucleotide kinase 3'-phosphatase 2.13612
KLHL21 kelch-like family member 21 2.13485
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 2.12145
TNIP1 TNFAIP3 interacting protein 1 2.11348
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 2.09938
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.0808
LGALS8 lectin, galactoside-binding, soluble, 8 2.0807
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.07944
SARAF store-operated calcium entry-associated regulatory factor 2.07595
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 2.06428
STXBP5L syntaxin binding protein 5-like 2.04916
FKBP14 FK506 binding protein 14, 22 kDa 2.04375
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.04335
SART1 squamous cell carcinoma antigen recognized by T cells 2.03964
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.03807
TMC5 transmembrane channel-like 5 2.03726
CHEK1 checkpoint kinase 1 2.03386
TMEM140 transmembrane protein 140 2.03295
OPTN optineurin 2.02876
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 2.01731
OSGIN2 oxidative stress induced growth inhibitor family member 2 2.01122
ZW10 zw10 kinetochore protein 2.00822
CLK3 CDC-like kinase 3 2.00441
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 2.00163

decreased expression

Symbol Name Standardized Value
STMN1 stathmin 1 -7.32351
TCTN1 tectonic family member 1 -7.17586
ADI1 acireductone dioxygenase 1 -6.49549
DNM1L dynamin 1-like -6.10049
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -6.04282
MELK maternal embryonic leucine zipper kinase -6.00304
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.92327
CCNA2 cyclin A2 -5.61199
CDK1 cyclin-dependent kinase 1 -5.39764
NUP85 nucleoporin 85kDa -5.24423
CCNB2 cyclin B2 -5.14848
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -5.1059
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -5.09292
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.83447
B4GAT1 beta-1,4-glucuronyltransferase 1 -4.57631
BLCAP bladder cancer associated protein -4.51734
ISOC1 isochorismatase domain containing 1 -4.49188
NT5DC2 5'-nucleotidase domain containing 2 -4.39586
BIRC5 baculoviral IAP repeat containing 5 -4.37153
PCCB propionyl CoA carboxylase, beta polypeptide -4.33634
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.28112
CDC20 cell division cycle 20 -4.25018
PLK1 polo-like kinase 1 -4.22346
PROS1 protein S (alpha) -4.18029
TOP2A topoisomerase (DNA) II alpha 170kDa -4.15606
PSRC1 proline/serine-rich coiled-coil 1 -4.13431
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.122
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.11988
POLR1A polymerase (RNA) I polypeptide A, 194kDa -4.08417
TMEM109 transmembrane protein 109 -4.07182
AURKB aurora kinase B -4.03183
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.94714
DDB2 damage-specific DNA binding protein 2, 48kDa -3.93401
LBR lamin B receptor -3.90248
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -3.78645
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.74535
CCDC86 coiled-coil domain containing 86 -3.73552
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.70542
SYNE2 spectrin repeat containing, nuclear envelope 2 -3.6648
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.61987
GDF15 growth differentiation factor 15 -3.58387
RPIA ribose 5-phosphate isomerase A -3.54225
ICAM3 intercellular adhesion molecule 3 -3.49015
HADH hydroxyacyl-CoA dehydrogenase -3.45403
HMGA2 high mobility group AT-hook 2 -3.3956
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -3.30205
PYCR1 pyrroline-5-carboxylate reductase 1 -3.30017
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.27146
TSPAN4 tetraspanin 4 -3.27139
NCAPD2 non-SMC condensin I complex, subunit D2 -3.25848
CDC25B cell division cycle 25B -3.25551
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.24495
GLOD4 glyoxalase domain containing 4 -3.16913
PGM1 phosphoglucomutase 1 -3.12572
TK1 thymidine kinase 1, soluble -3.12485
ILK integrin-linked kinase -3.11273
ASF1B anti-silencing function 1B histone chaperone -3.10682
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.02575
HMG20B high mobility group 20B -2.83001
LDHD lactate dehydrogenase D -2.82791
CHEK2 checkpoint kinase 2 -2.72086
FOXM1 forkhead box M1 -2.7163
C2CD5 C2 calcium-dependent domain containing 5 -2.70843
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.70144
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.60955
SMC4 structural maintenance of chromosomes 4 -2.59608
PRPF4 pre-mRNA processing factor 4 -2.58931
FGFR4 fibroblast growth factor receptor 4 -2.5563
VDAC1 voltage-dependent anion channel 1 -2.55169
RFC2 replication factor C (activator 1) 2, 40kDa -2.53127
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.5294
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.52293
ETFB electron-transfer-flavoprotein, beta polypeptide -2.52196
ZNF586 zinc finger protein 586 -2.50615
TRMT5 tRNA methyltransferase 5 -2.50177
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.49646
TRAP1 TNF receptor-associated protein 1 -2.47834
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.45842
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.44093
INTS3 integrator complex subunit 3 -2.42367
PCNA proliferating cell nuclear antigen -2.40175
ZWINT ZW10 interacting kinetochore protein -2.39673
PGAM4 phosphoglycerate mutase family member 4 -2.39479
UBE2C ubiquitin-conjugating enzyme E2C -2.38319
TERT telomerase reverse transcriptase -2.35874
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.332
ACOT9 acyl-CoA thioesterase 9 -2.31995
GAA glucosidase, alpha; acid -2.27897
CDKN3 cyclin-dependent kinase inhibitor 3 -2.27453
TMEM97 transmembrane protein 97 -2.26147
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.25617
CENPA centromere protein A -2.2448
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.22665
PECR peroxisomal trans-2-enoyl-CoA reductase -2.21624
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.21337
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.20618
TPM1 tropomyosin 1 (alpha) -2.2028
TLCD3A TLC domain containing 3A -2.20246
KIF14 kinesin family member 14 -2.20092
ACOD1 aconitate decarboxylase 1 -2.16681
CDK2 cyclin-dependent kinase 2 -2.15845
TIMELESS timeless circadian clock -2.15715
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.13583
CD320 CD320 molecule -2.13173
COPS7A COP9 signalosome subunit 7A -2.1155
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.10217
NSD2 nuclear receptor binding SET domain protein 2 -2.09794
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 -2.09171
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.08925
FANCG Fanconi anemia, complementation group G -2.07272
CCNB1 cyclin B1 -2.07116
KIF4A kinesin family member 4A -2.0674
CLUH clustered mitochondria (cluA/CLU1) homolog -2.05471
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.03357
APEH acylaminoacyl-peptide hydrolase -2.03326
MYLK myosin light chain kinase -2.02695
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.02457
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.02242
KMT5A lysine methyltransferase 5A -2.01216