CRCGN012_HEPG2_24H:D19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description g-butyrolactone 39.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN012_HEPG2_24H:D19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 7.73676
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.49227
BZW2 basic leucine zipper and W2 domains 2 4.24039
TIAM1 T-cell lymphoma invasion and metastasis 1 3.59144
HOXA10 homeobox A10 3.58247
CBR3 carbonyl reductase 3 3.38547
RPP38 ribonuclease P/MRP 38kDa subunit 3.28378
LPAR2 lysophosphatidic acid receptor 2 3.04161
NOSIP nitric oxide synthase interacting protein 2.78783
CEP57 centrosomal protein 57kDa 2.77375
SYNE2 spectrin repeat containing, nuclear envelope 2 2.36772
CIAO3 cytosolic iron-sulfur assembly component 3 2.16525
MCOLN1 mucolipin 1 2.11351
KIF20A kinesin family member 20A 2.06432
GSTZ1 glutathione S-transferase zeta 1 2.05607

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -9.56086
MRPS2 mitochondrial ribosomal protein S2 -7.7793
LDHD lactate dehydrogenase D -6.54143
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.57377
FAIM Fas apoptotic inhibitory molecule -4.43517
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.41833
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.40248
CD320 CD320 molecule -4.09575
CDC20 cell division cycle 20 -4.01627
KDM3A lysine (K)-specific demethylase 3A -3.60845
TLCD3A TLC domain containing 3A -3.25133
SLC35F2 solute carrier family 35, member F2 -3.12688
TRIB3 tribbles pseudokinase 3 -3.02835
ISOC1 isochorismatase domain containing 1 -2.81694
EGF epidermal growth factor -2.70397
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.30756
CCNB1 cyclin B1 -2.26329
USP6NL USP6 N-terminal like -2.13488
TES testin LIM domain protein -2.10541
CXCR5 chemokine (C-X-C motif) receptor 5 -2.04542