CRCGN012_HEPG2_24H:D20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description g-butyrolactone 19.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

116 genes differentially expressed following the CRCGN012_HEPG2_24H:D20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.54094
CIAO3 cytosolic iron-sulfur assembly component 3 5.5352
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.42678
BACE2 beta-site APP-cleaving enzyme 2 5.34275
E2F2 E2F transcription factor 2 5.2944
RPP38 ribonuclease P/MRP 38kDa subunit 5.25554
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.23914
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.1639
CHMP6 charged multivesicular body protein 6 4.82185
CBR3 carbonyl reductase 3 4.61162
ADRB2 adrenoceptor beta 2, surface 4.59762
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.44816
ATP11B ATPase, class VI, type 11B 4.2254
PRR15L proline rich 15-like 4.01249
PPARG peroxisome proliferator-activated receptor gamma 3.76917
GATA3 GATA binding protein 3 3.50405
GARRE1 granule associated Rac and RHOG effector 1 3.49812
RXYLT1 ribitol xylosyltransferase 1 3.22222
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.18972
TIAM1 T-cell lymphoma invasion and metastasis 1 2.8581
MAST2 microtubule associated serine/threonine kinase 2 2.84433
CREG1 cellular repressor of E1A-stimulated genes 1 2.82074
LSR lipolysis stimulated lipoprotein receptor 2.68098
KDM5A lysine (K)-specific demethylase 5A 2.64455
EPHA3 EPH receptor A3 2.64317
CTSE cathepsin E 2.6132
CYCS cytochrome c, somatic 2.57628
SKAP1 src kinase associated phosphoprotein 1 2.52728
JADE2 jade family PHD finger 2 2.51502
CATSPERG catsper channel auxiliary subunit gamma 2.49168
ZNF589 zinc finger protein 589 2.47196
CCNH cyclin H 2.46241
GRIK4 glutamate receptor, ionotropic, kainate 4 2.37692
ANO10 anoctamin 10 2.3676
FRG1 FSHD region gene 1 2.35695
ZNF280B zinc finger protein 280B 2.34389
GPER1 G protein-coupled estrogen receptor 1 2.31366
MC3R melanocortin 3 receptor 2.30216
MCRS1 microspherule protein 1 2.2902
GJA5 gap junction protein, alpha 5, 40kDa 2.28539
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.26096
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 2.25457
NABP2 nucleic acid binding protein 2 2.24483
PCNA proliferating cell nuclear antigen 2.24195
PTK6 protein tyrosine kinase 6 2.23369
IL12RB1 interleukin 12 receptor, beta 1 2.22366
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.19067
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.17561
IL12A interleukin 12A 2.16961
EMC10 ER membrane protein complex subunit 10 2.15343
EMX1 empty spiracles homeobox 1 2.1466
PRSS50 protease, serine, 50 2.1349
PAX7 paired box 7 2.13293
TBPL1 TBP-like 1 2.11743
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 2.11614
SFTPB surfactant protein B 2.11001
LGALS4 lectin, galactoside-binding, soluble, 4 2.08862
INTS3 integrator complex subunit 3 2.08693
CD247 CD247 molecule 2.08567
POLM polymerase (DNA directed), mu 2.07873
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 2.07507
PCDHGC3 protocadherin gamma subfamily C, 3 2.07096
CASP9 caspase 9, apoptosis-related cysteine peptidase 2.06207
CD1C CD1c molecule 2.05391
COL19A1 collagen, type XIX, alpha 1 2.03325
CDHR2 cadherin-related family member 2 2.0184
ACVR2B activin A receptor, type IIB 2.01493
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.01051
POU3F3 POU class 3 homeobox 3 2.00703
PMF1-BGLAP PMF1-BGLAP readthrough 2.00617
AIRE autoimmune regulator 2.0011
DPPA4 developmental pluripotency associated 4 2.00002

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -8.79342
FASTKD5 FAST kinase domains 5 -5.78412
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.54454
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.49916
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.31916
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.16525
HAT1 histone acetyltransferase 1 -5.02724
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.88792
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.63837
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.54271
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.22595
CCNB1 cyclin B1 -4.19993
CAB39 calcium binding protein 39 -4.08003
ITGB1BP1 integrin beta 1 binding protein 1 -3.82475
PTPRK protein tyrosine phosphatase, receptor type, K -3.38582
CAPNS1 calpain, small subunit 1 -3.2722
ZMIZ1 zinc finger, MIZ-type containing 1 -3.22337
FGFR4 fibroblast growth factor receptor 4 -3.08943
MAPK13 mitogen-activated protein kinase 13 -3.06079
PRPF4 pre-mRNA processing factor 4 -2.99883
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.79394
MTCH1 mitochondrial carrier 1 -2.70574
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.66845
RHEB Ras homolog enriched in brain -2.61302
EIF5 eukaryotic translation initiation factor 5 -2.39279
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.36289
RGS2 regulator of G-protein signaling 2 -2.35963
TBCC tubulin folding cofactor C -2.35796
CCDC86 coiled-coil domain containing 86 -2.32322
RPS5 ribosomal protein S5 -2.32225
SULT4A1 sulfotransferase family 4A, member 1 -2.26438
NGRN neugrin, neurite outgrowth associated -2.25373
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -2.24383
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.20057
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa -2.19134
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.17007
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -2.16987
RAB5IF RAB5 interacting factor -2.1436
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator -2.14199
USPL1 ubiquitin specific peptidase like 1 -2.1275
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) -2.0499
RBM7 RNA binding motif protein 7 -2.03983
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough -2.03115
OLFML2A olfactomedin-like 2A -2.02192