| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | g-butyrolactone 9.8 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
| Downloads & Tools |
68 genes differentially expressed following the CRCGN012_HEPG2_24H:D21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 6.5124 |
| MOK | MOK protein kinase | 6.12796 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 4.04343 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.80906 |
| CSK | c-src tyrosine kinase | 3.79279 |
| CHMP6 | charged multivesicular body protein 6 | 3.43031 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | 3.32786 |
| PRR15L | proline rich 15-like | 3.30976 |
| ATP11B | ATPase, class VI, type 11B | 3.27746 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 3.24261 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 3.2309 |
| NOTCH1 | notch 1 | 3.21943 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.10534 |
| CBR3 | carbonyl reductase 3 | 3.0907 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 3.02521 |
| EPN2 | epsin 2 | 3.01932 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.97123 |
| TAC4 | tachykinin 4 (hemokinin) | 2.95144 |
| E2F2 | E2F transcription factor 2 | 2.89016 |
| PNKP | polynucleotide kinase 3'-phosphatase | 2.78431 |
| MICALL1 | MICAL-like 1 | 2.65959 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 2.62262 |
| PRKCH | protein kinase C, eta | 2.55329 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 2.47469 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.36956 |
| PIP4K2B | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | 2.35425 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 2.30331 |
| PCDHB11 | protocadherin beta 11 | 2.21004 |
| POLR2F | polymerase (RNA) II (DNA directed) polypeptide F | 2.20079 |
| FZD7 | frizzled class receptor 7 | 2.17225 |
| MTERF3 | mitochondrial transcription termination factor 3 | 2.08223 |
| STIMATE | STIM activating enhancer | 2.01366 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.00215 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.00031 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF586 | zinc finger protein 586 | -6.64435 |
| PCNA | proliferating cell nuclear antigen | -4.27046 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -3.95639 |
| PLK1 | polo-like kinase 1 | -3.81689 |
| TUBB6 | tubulin, beta 6 class V | -3.74278 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -3.69301 |
| DSG2 | desmoglein 2 | -3.60156 |
| STX4 | syntaxin 4 | -3.59727 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.34997 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.34229 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.29498 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -3.23409 |
| SLC35F2 | solute carrier family 35, member F2 | -3.21431 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.13143 |
| LAP3 | leucine aminopeptidase 3 | -3.06574 |
| NGRN | neugrin, neurite outgrowth associated | -2.99141 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -2.9726 |
| GNAS | GNAS complex locus | -2.83416 |
| PRPF4 | pre-mRNA processing factor 4 | -2.80348 |
| NISCH | nischarin | -2.69309 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -2.68117 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | -2.67273 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -2.64716 |
| RGS2 | regulator of G-protein signaling 2 | -2.62336 |
| ZW10 | zw10 kinetochore protein | -2.39209 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.31062 |
| NCK1 | NCK adaptor protein 1 | -2.30476 |
| TXNRD1 | thioredoxin reductase 1 | -2.28758 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.28473 |
| EGF | epidermal growth factor | -2.18345 |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | -2.13355 |
| ITGA1 | integrin, alpha 1 | -2.12084 |
| CD58 | CD58 molecule | -2.09936 |
| DYSF | dysferlin | -2.06314 |
