CRCGN012_HEPG2_24H:D22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description g-butyrolactone 4.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN012_HEPG2_24H:D22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.66884
STIMATE STIM activating enhancer 5.90332
RPL39L ribosomal protein L39-like 4.36452
AMDHD2 amidohydrolase domain containing 2 4.11702
ADRB2 adrenoceptor beta 2, surface 3.8829
HOXA10 homeobox A10 3.62037
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.58614
CBR3 carbonyl reductase 3 3.52851
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.49349
UBQLN2 ubiquilin 2 3.43933
NOTCH1 notch 1 3.38525
GPATCH8 G patch domain containing 8 3.37617
PNKP polynucleotide kinase 3'-phosphatase 3.21188
PRR15L proline rich 15-like 3.16819
BACE2 beta-site APP-cleaving enzyme 2 3.0995
EPHB2 EPH receptor B2 2.89877
ZNF589 zinc finger protein 589 2.85544
PRKCH protein kinase C, eta 2.66169
PFKL phosphofructokinase, liver 2.61374
STK10 serine/threonine kinase 10 2.59893
E2F2 E2F transcription factor 2 2.58867
NLRP2B NLR family pyrin domain containing 2B 2.50524
MAP7 microtubule-associated protein 7 2.48966
ATP11B ATPase, class VI, type 11B 2.48813
LCN2 lipocalin 2 2.44142
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.41582
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.41481
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.37723
MAMLD1 mastermind-like domain containing 1 2.28037
FSD1 fibronectin type III and SPRY domain containing 1 2.24186
ACBD4 acyl-CoA binding domain containing 4 2.21844
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.1499
SNAP25 synaptosomal-associated protein, 25kDa 2.12693
YPEL1 yippee-like 1 (Drosophila) 2.0909
MELTF melanotransferrin 2.08834
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.08457
SFTPB surfactant protein B 2.06031
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.05078
ARHGAP4 Rho GTPase activating protein 4 2.04328

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.50663
DNM1L dynamin 1-like -5.9607
CCNB2 cyclin B2 -4.81793
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.91465
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.69465
KDM3A lysine (K)-specific demethylase 3A -3.61772
UGDH UDP-glucose 6-dehydrogenase -3.58208
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.40658
RPIA ribose 5-phosphate isomerase A -3.33123
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.27354
ADI1 acireductone dioxygenase 1 -3.26653
PCNA proliferating cell nuclear antigen -3.22275
CDC20 cell division cycle 20 -3.16196
TCERG1 transcription elongation regulator 1 -2.8476
CCNB1 cyclin B1 -2.83887
LDHD lactate dehydrogenase D -2.8353
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.72602
ZMIZ1 zinc finger, MIZ-type containing 1 -2.22897
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.1952
GRB7 growth factor receptor-bound protein 7 -2.18011