CRCGN012_HEPG2_24H:D24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description g-butyrolactone 1.23 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN012_HEPG2_24H:D24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPP38 ribonuclease P/MRP 38kDa subunit 5.22817
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.43953
GSTZ1 glutathione S-transferase zeta 1 3.91728
NOSIP nitric oxide synthase interacting protein 3.89237
GPATCH8 G patch domain containing 8 3.85807
MOK MOK protein kinase 3.41716
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.36067
CSK c-src tyrosine kinase 2.98612
IDE insulin-degrading enzyme 2.65921
ATP11B ATPase, class VI, type 11B 2.56403
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.52171
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.42762
UBQLN2 ubiquilin 2 2.34449
PCNA proliferating cell nuclear antigen 2.29624
EXOSC8 exosome component 8 2.18665
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.07508
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.0023

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.65509
GOLT1B golgi transport 1B -4.82554
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.59309
GNAS GNAS complex locus -4.48448
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.44212
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.79099
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.20813
VDAC1 voltage-dependent anion channel 1 -2.9203
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.83236
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.81236
TOMM34 translocase of outer mitochondrial membrane 34 -2.60939
PRPF4 pre-mRNA processing factor 4 -2.51139
DDIT4 DNA-damage-inducible transcript 4 -2.3925
SLC35H1 solute carrier family 35 member H1 -2.24529
PDLIM1 PDZ and LIM domain 1 -2.14098
ITGB6 integrin, beta 6 -2.11732
PDCD6 programmed cell death 6 -2.10596
FGFR4 fibroblast growth factor receptor 4 -2.06393
MAP7 microtubule-associated protein 7 -2.0586
SNX11 sorting nexin 11 -2.05375
NOL4 nucleolar protein 4 -2.03322
MTMR14 myotubularin related protein 14 -2.02236
HLA-DMA major histocompatibility complex, class II, DM alpha -2.02022