CRCGN012_HEPG2_24H:E01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description iq 21.02 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

84 genes differentially expressed following the CRCGN012_HEPG2_24H:E01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 6.67752
STK10 serine/threonine kinase 10 6.25984
ABHD6 abhydrolase domain containing 6 5.63219
CCDC86 coiled-coil domain containing 86 5.173
TIAM1 T-cell lymphoma invasion and metastasis 1 4.3572
ANO1 anoctamin 1, calcium activated chloride channel 4.13603
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4.06758
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.91601
MCOLN1 mucolipin 1 3.61253
PPARG peroxisome proliferator-activated receptor gamma 3.58367
RPL39L ribosomal protein L39-like 3.52635
CYCS cytochrome c, somatic 3.38541
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.29389
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.28918
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.26703
BACE2 beta-site APP-cleaving enzyme 2 3.25739
RAP1GAP RAP1 GTPase activating protein 3.08032
MOK MOK protein kinase 2.89067
VAT1 vesicle amine transport 1 2.66023
FKBP5 FK506 binding protein 5 2.63743
KIFBP kinesin family binding protein 2.61547
SMIM40 small integral membrane protein 40 2.58241
HDGFL3 HDGF like 3 2.57099
ATP11B ATPase, class VI, type 11B 2.50797
OLAH oleoyl-ACP hydrolase 2.47792
GATA3 GATA binding protein 3 2.47334
DDIT4 DNA-damage-inducible transcript 4 2.46211
NPDC1 neural proliferation, differentiation and control, 1 2.34516
LGALSL lectin, galactoside-binding-like 2.31068
FCHO1 FCH domain only 1 2.29292
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.26742
GRK3 G protein-coupled receptor kinase 3 2.20657
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.17854
SEMG1 semenogelin I 2.17659
LOC122526780 uncharacterized LOC122526780 2.17281
DUSP6 dual specificity phosphatase 6 2.15011
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.14716
ZNF107 zinc finger protein 107 2.14173
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.12913
TBP TATA box binding protein 2.11273
GPER1 G protein-coupled estrogen receptor 1 2.07267
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.06413
TXNRD1 thioredoxin reductase 1 2.03423
ZFP36 ZFP36 ring finger protein 2.02676
SEMG2 semenogelin II 2.02144
TUBA3E tubulin, alpha 3e 2.01826
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.01048
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 2.00993
ETFB electron-transfer-flavoprotein, beta polypeptide 2.00088

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.04667
PCNA proliferating cell nuclear antigen -5.95362
CCNB2 cyclin B2 -4.88486
DSG2 desmoglein 2 -4.079
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.96788
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.85932
RPIA ribose 5-phosphate isomerase A -3.68244
KDM3A lysine (K)-specific demethylase 3A -3.54272
CRELD2 cysteine-rich with EGF-like domains 2 -3.42808
CCNB1 cyclin B1 -3.42328
IER3 immediate early response 3 -3.34354
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.23276
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.21994
TRIB3 tribbles pseudokinase 3 -3.07336
YME1L1 YME1-like 1 ATPase -2.92354
SPAG4 sperm associated antigen 4 -2.67973
NGRN neugrin, neurite outgrowth associated -2.67848
ICAM3 intercellular adhesion molecule 3 -2.54824
ZMIZ1 zinc finger, MIZ-type containing 1 -2.46513
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.32733
NRIP1 nuclear receptor interacting protein 1 -2.22272
MAPK13 mitogen-activated protein kinase 13 -2.22035
GID8 GID complex subunit 8 -2.216
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.16599
IFITM1 interferon induced transmembrane protein 1 -2.1572
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.14221
TOR1A torsin family 1, member A (torsin A) -2.13482
SOX4 SRY (sex determining region Y)-box 4 -2.12245
PARP12 poly (ADP-ribose) polymerase family, member 12 -2.1158
IRGQ immunity-related GTPase family, Q -2.11189
PRPF18 pre-mRNA processing factor 18 -2.1095
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.09196
RAI14 retinoic acid induced 14 -2.06113
SLC35B1 solute carrier family 35, member B1 -2.0509
TRIM24 tripartite motif containing 24 -2.01122