CRCGN012_HEPG2_24H:E03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description iq 5.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN012_HEPG2_24H:E03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPP38 ribonuclease P/MRP 38kDa subunit 6.79771
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.59402
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.2126
PRR15L proline rich 15-like 5.8644
CCL2 chemokine (C-C motif) ligand 2 5.84535
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 5.01402
JADE2 jade family PHD finger 2 3.47378
GPER1 G protein-coupled estrogen receptor 1 3.32694
DENND2D DENN/MADD domain containing 2D 3.25944
LOC122526780 uncharacterized LOC122526780 3.19465
CBR3 carbonyl reductase 3 3.18483
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.14792
E2F2 E2F transcription factor 2 3.12842
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.69314
VAV3 vav 3 guanine nucleotide exchange factor 2.50206
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.4894
CIAO3 cytosolic iron-sulfur assembly component 3 2.47994
CSK c-src tyrosine kinase 2.29752
CEP57 centrosomal protein 57kDa 2.26544

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -6.04723
VAT1 vesicle amine transport 1 -5.6655
CCNB2 cyclin B2 -4.50661
MRPS2 mitochondrial ribosomal protein S2 -3.47535
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.44178
RAI14 retinoic acid induced 14 -3.38681
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.2143
TLCD3A TLC domain containing 3A -2.96028
CD320 CD320 molecule -2.89706
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.88106
ZNF586 zinc finger protein 586 -2.77317
MAP7 microtubule-associated protein 7 -2.70754
PCNA proliferating cell nuclear antigen -2.57013
GOLT1B golgi transport 1B -2.56435
GNAS GNAS complex locus -2.50028
YME1L1 YME1-like 1 ATPase -2.38809
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.35815
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.3404
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.22059
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.19574
ZNF551 zinc finger protein 551 -2.1332
EIF5 eukaryotic translation initiation factor 5 -2.12418
CTSD cathepsin D -2.01646