CRCGN012_HEPG2_24H:E05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description iq 1.31 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

112 genes differentially expressed following the CRCGN012_HEPG2_24H:E05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 6.68543
AMDHD2 amidohydrolase domain containing 2 5.34983
ABHD6 abhydrolase domain containing 6 5.34677
ADGRE5 adhesion G protein-coupled receptor E5 5.1401
UBQLN2 ubiquilin 2 4.40247
STIMATE STIM activating enhancer 4.30347
CAPN1 calpain 1, (mu/I) large subunit 3.9626
PPARG peroxisome proliferator-activated receptor gamma 3.56313
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.50623
ANO1 anoctamin 1, calcium activated chloride channel 3.33333
CBR1 carbonyl reductase 1 3.31587
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.28523
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.28201
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.20637
CRTAP cartilage associated protein 3.14567
CTSL cathepsin L 2.9526
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.60801
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.56165
RPP38 ribonuclease P/MRP 38kDa subunit 2.52173
CSK c-src tyrosine kinase 2.50347
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.43327
STK10 serine/threonine kinase 10 2.42532
SPOUT1 SPOUT domain containing methyltransferase 1 2.3779
GPATCH8 G patch domain containing 8 2.37417
SCRN1 secernin 1 2.37187
CHN1 chimerin 1 2.21227
CYCS cytochrome c, somatic 2.21183
TATDN2 TatD DNase domain containing 2 2.17857
OXCT1 3-oxoacid CoA transferase 1 2.12723
RPL21 ribosomal protein L21 2.12513
C8A complement component 8, alpha polypeptide 2.11843
F9 coagulation factor IX 2.11223
SAA2 serum amyloid A2 2.10757
HSPD1 heat shock 60kDa protein 1 (chaperonin) 2.10562
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2.08343
DYNLRB1 dynein, light chain, roadblock-type 1 2.06988
PRKCD protein kinase C, delta 2.04213
EVL Enah/Vasp-like 2.00467

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -6.66667
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -6.28627
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.40123
FASTKD5 FAST kinase domains 5 -3.8918
UBE3C ubiquitin protein ligase E3C -3.7292
CRELD2 cysteine-rich with EGF-like domains 2 -3.65293
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -3.64497
PCNA proliferating cell nuclear antigen -3.57323
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.44393
EGF epidermal growth factor -3.44367
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.4138
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -3.3967
USP6NL USP6 N-terminal like -3.38283
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.38213
CDC25B cell division cycle 25B -3.33853
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.33333
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.31003
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.2915
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.27933
ZMIZ1 zinc finger, MIZ-type containing 1 -3.20257
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -3.20143
LDHD lactate dehydrogenase D -3.1909
UGDH UDP-glucose 6-dehydrogenase -3.18187
CGRRF1 cell growth regulator with ring finger domain 1 -3.1736
ZNF586 zinc finger protein 586 -3.13587
TRIB3 tribbles pseudokinase 3 -3.11207
PMM2 phosphomannomutase 2 -3.02607
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.02353
GOLT1B golgi transport 1B -3.02097
CHMP4B charged multivesicular body protein 4B -3.01213
CHEK1 checkpoint kinase 1 -2.97657
HMG20B high mobility group 20B -2.9619
PECR peroxisomal trans-2-enoyl-CoA reductase -2.9615
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.93443
TM9SF3 transmembrane 9 superfamily member 3 -2.93203
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.93103
TLCD3A TLC domain containing 3A -2.9277
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.89837
CD58 CD58 molecule -2.89826
MKNK1 MAP kinase interacting serine/threonine kinase 1 -2.8492
LOC124907782 dual specificity protein phosphatase 22 -2.84163
PEG10 paternally expressed 10 -2.80982
GDF15 growth differentiation factor 15 -2.78113
SESN1 sestrin 1 -2.77867
FGFR4 fibroblast growth factor receptor 4 -2.76878
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.73653
TCTN1 tectonic family member 1 -2.70667
CD320 CD320 molecule -2.69713
CDC45 cell division cycle 45 -2.66593
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.61547
SLC35F2 solute carrier family 35, member F2 -2.5332
MAP7 microtubule-associated protein 7 -2.53192
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.48737
MACF1 microtubule-actin crosslinking factor 1 -2.42853
MELK maternal embryonic leucine zipper kinase -2.41793
DNM1L dynamin 1-like -2.39687
MALT1 MALT1 paracaspase -2.36237
RNPS1 RNA binding protein S1, serine-rich domain -2.35875
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.34835
DNM3 dynamin 3 -2.34647
REG1B regenerating islet-derived 1 beta -2.30847
HYOU1 hypoxia up-regulated 1 -2.304
CCNB2 cyclin B2 -2.28377
KIAA0930 KIAA0930 -2.27182
ZBTB35 zinc finger and BTB domain containing 35 -2.2311
NVL nuclear VCP-like -2.22353
TES testin LIM domain protein -2.18225
HSPA1A heat shock 70kDa protein 1A -2.12997
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.11313
COL17A1 collagen, type XVII, alpha 1 -2.1038
CLTB clathrin, light chain B -2.08998
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.01017
PRPF4 pre-mRNA processing factor 4 -2.0043
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 -2.00407