CRCGN012_HEPG2_24H:E06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description iq 0.66 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

95 genes differentially expressed following the CRCGN012_HEPG2_24H:E06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
MAMLD1 mastermind-like domain containing 1 8.62832
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 6.14105
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.9451
EVL Enah/Vasp-like 5.33352
CAPN1 calpain 1, (mu/I) large subunit 5.04182
CSK c-src tyrosine kinase 4.98599
CHMP6 charged multivesicular body protein 6 4.8551
IDE insulin-degrading enzyme 4.74138
TIAM1 T-cell lymphoma invasion and metastasis 1 4.69767
NOTCH1 notch 1 4.60671
ANO1 anoctamin 1, calcium activated chloride channel 4.35173
SNAP25 synaptosomal-associated protein, 25kDa 4.34336
ATP11B ATPase, class VI, type 11B 3.9308
RPL39L ribosomal protein L39-like 3.77277
PLSCR1 phospholipid scramblase 1 3.75008
CBR3 carbonyl reductase 3 3.55149
LOC122526780 uncharacterized LOC122526780 3.42996
PRKCH protein kinase C, eta 3.39616
RBKS ribokinase 3.17066
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 3.09256
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.9584
PNKP polynucleotide kinase 3'-phosphatase 2.94719
IFI44L interferon-induced protein 44-like 2.9366
HOXA10 homeobox A10 2.93287
MOK MOK protein kinase 2.93111
LPAR2 lysophosphatidic acid receptor 2 2.90302
MX1 MX dynamin-like GTPase 1 2.7939
CYCS cytochrome c, somatic 2.76291
CPB2 carboxypeptidase B2 (plasma) 2.69229
MAOB monoamine oxidase B 2.66363
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.62717
TBP TATA box binding protein 2.6265
BLM Bloom syndrome, RecQ helicase-like 2.60733
BCL2 B-cell CLL/lymphoma 2 2.56956
CCL2 chemokine (C-C motif) ligand 2 2.51605
IFI44 interferon-induced protein 44 2.48715
ISG15 ISG15 ubiquitin-like modifier 2.37879
VRK2 vaccinia related kinase 2 2.35127
CHAF1B chromatin assembly factor 1, subunit B (p60) 2.34654
HLF hepatic leukemia factor 2.31991
ATF7IP2 activating transcription factor 7 interacting protein 2 2.29608
GPX7 glutathione peroxidase 7 2.29403
MTM1 myotubularin 1 2.29363
ORM2 orosomucoid 2 2.2679
RASL12 RAS-like, family 12 2.20864
CLDN10 claudin 10 2.20249
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.19551
RBP1 retinol binding protein 1, cellular 2.14935
ORM1 orosomucoid 1 2.13665
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 2.10959
C1RL complement component 1, r subcomponent-like 2.07977
TPK1 thiamin pyrophosphokinase 1 2.06492
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 2.06393
MX2 MX dynamin-like GTPase 2 2.06307
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.06173
PLCD1 phospholipase C, delta 1 2.05527
IL18R1 interleukin 18 receptor 1 2.05421
USP18 ubiquitin specific peptidase 18 2.04131
XAF1 XIAP associated factor 1 2.02771
ANKRD6 ankyrin repeat domain 6 2.00704

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -8.4957
CCNB2 cyclin B2 -7.6645
LDHD lactate dehydrogenase D -6.11648
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.33089
ZNF586 zinc finger protein 586 -5.02921
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.77454
ADI1 acireductone dioxygenase 1 -4.45792
CCNB1 cyclin B1 -4.12691
LYPLA1 lysophospholipase I -3.69151
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.65307
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.55565
GDF15 growth differentiation factor 15 -3.52679
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.39829
TSPAN4 tetraspanin 4 -3.35318
RAI14 retinoic acid induced 14 -3.34426
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.07063
SCAND1 SCAN domain containing 1 -2.98997
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.74944
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.73259
WASHC4 WASH complex subunit 4 -2.60797
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.59342
KDM3A lysine (K)-specific demethylase 3A -2.47016
ARID5B AT rich interactive domain 5B (MRF1-like) -2.42891
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) -2.2862
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.28362
ASPHD1 aspartate beta-hydroxylase domain containing 1 -2.27759
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.27575
SSBP2 single-stranded DNA binding protein 2 -2.13928
ITGB1BP1 integrin beta 1 binding protein 1 -2.12589
NVL nuclear VCP-like -2.09463
RGS2 regulator of G-protein signaling 2 -2.07763
POMT1 protein-O-mannosyltransferase 1 -2.06635
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) -2.05648
NLRP4 NLR family, pyrin domain containing 4 -2.00122