CRCGN012_HEPG2_24H:E07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description kynurenic-acid 21.15 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

258 genes differentially expressed following the CRCGN012_HEPG2_24H:E07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 8.12046
OXCT1 3-oxoacid CoA transferase 1 7.89295
CSK c-src tyrosine kinase 7.77092
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 7.45015
E2F2 E2F transcription factor 2 7.41333
BACE2 beta-site APP-cleaving enzyme 2 6.35968
INSIG1 insulin induced gene 1 6.32126
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 5.8732
CCNF cyclin F 5.29014
SNAP25 synaptosomal-associated protein, 25kDa 5.08748
TIAM1 T-cell lymphoma invasion and metastasis 1 4.92883
SYNE2 spectrin repeat containing, nuclear envelope 2 4.83661
LOXL1 lysyl oxidase-like 1 4.58537
GATA3 GATA binding protein 3 4.40875
MYLK myosin light chain kinase 4.3413
HSPA1A heat shock 70kDa protein 1A 4.31363
CHMP6 charged multivesicular body protein 6 4.27647
PPARG peroxisome proliferator-activated receptor gamma 4.13717
PARP1 poly (ADP-ribose) polymerase 1 4.11561
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.03974
VAV3 vav 3 guanine nucleotide exchange factor 3.79332
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.69567
HDGFL3 HDGF like 3 3.61756
EDN1 endothelin 1 3.60687
PRR15L proline rich 15-like 3.47226
RXYLT1 ribitol xylosyltransferase 1 3.42075
LPAR2 lysophosphatidic acid receptor 2 3.39328
EPHA3 EPH receptor A3 3.37606
RPL39L ribosomal protein L39-like 3.36785
STK10 serine/threonine kinase 10 3.32157
MAMLD1 mastermind-like domain containing 1 3.32099
CDKN2A cyclin-dependent kinase inhibitor 2A 3.29567
CDPF1 cysteine-rich, DPF motif domain containing 1 3.19342
GPER1 G protein-coupled estrogen receptor 1 3.12686
KDM4D lysine (K)-specific demethylase 4D 3.12321
ZPBP zona pellucida binding protein 3.08185
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.07395
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.01443
SQOR sulfide quinone oxidoreductase 3.00432
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.98034
STX1A syntaxin 1A (brain) 2.97539
CRISP2 cysteine-rich secretory protein 2 2.96439
LOC107985101 uncharacterized LOC107985101 2.83746
DYNLT3 dynein, light chain, Tctex-type 3 2.7351
IFNA13 interferon, alpha 13 2.68835
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.68835
PLAGL1 pleiomorphic adenoma gene-like 1 2.64282
CBR1 carbonyl reductase 1 2.62012
CHN1 chimerin 1 2.61823
CYCS cytochrome c, somatic 2.57651
GNG11 guanine nucleotide binding protein (G protein), gamma 11 2.57035
DHDDS dehydrodolichyl diphosphate synthase 2.56714
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.55091
TBC1D10C TBC1 domain family, member 10C 2.53446
PRB2 proline-rich protein BstNI subfamily 2 2.52662
IL17RB interleukin 17 receptor B 2.52611
PRB4 proline-rich protein BstNI subfamily 4 2.52099
VAT1 vesicle amine transport 1 2.51088
STIMATE STIM activating enhancer 2.51007
SLC6A16 solute carrier family 6, member 16 2.50671
TEX30 testis expressed 30 2.49011
H2AB2 H2A.B variant histone 2 2.48603
AGTR1 angiotensin II receptor, type 1 2.48593
ANKRD7 ankyrin repeat domain 7 2.48422
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.48276
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.48041
NINL ninein-like 2.47949
LOC100652777 group 10 secretory phospholipase A2-like 2.46381
ZCWPW1 zinc finger, CW type with PWWP domain 1 2.4551
CCNK cyclin K 2.44347
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 2.44092
MAP7 microtubule-associated protein 7 2.43322
KIF17 kinesin family member 17 2.42435
ODF1 outer dense fiber of sperm tails 1 2.40009
KANSL1L KAT8 regulatory NSL complex subunit 1-like 2.39646
WDR4 WD repeat domain 4 2.39584
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 2.38381
CNTNAP1 contactin associated protein 1 2.38162
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.38089
LRRN3 leucine rich repeat neuronal 3 2.37907
SMR3A submaxillary gland androgen regulated protein 3A 2.37604
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.3741
EVX1 even-skipped homeobox 1 2.36529
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 2.34969
IGHMBP2 immunoglobulin mu binding protein 2 2.34079
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 2.32432
JAM2 junctional adhesion molecule 2 2.3233
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 2.31247
MOG myelin oligodendrocyte glycoprotein 2.31212
RBM15B RNA binding motif protein 15B 2.31163
RASAL1 RAS protein activator like 1 (GAP1 like) 2.30834
EHD3 EH-domain containing 3 2.30778
DPPA4 developmental pluripotency associated 4 2.30729
HLA-DMA major histocompatibility complex, class II, DM alpha 2.2981
GSTZ1 glutathione S-transferase zeta 1 2.28803
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.27611
CNTN6 contactin 6 2.2688
NHLH1 nescient helix loop helix 1 2.26737
KRTAP5-3 keratin associated protein 5-3 2.26656
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.26512
MSRA methionine sulfoxide reductase A 2.26351
ZNF280B zinc finger protein 280B 2.26033
PXDNL peroxidasin-like 2.25863
TTLL7 tubulin tyrosine ligase-like family member 7 2.25673
BATF basic leucine zipper transcription factor, ATF-like 2.25053
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 2.2475
SHBG sex hormone-binding globulin 2.24618
ASPHD1 aspartate beta-hydroxylase domain containing 1 2.24214
CAVIN3 caveolae associated protein 3 2.2384
NEUROD2 neuronal differentiation 2 2.23827
GP6 glycoprotein VI (platelet) 2.22885
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 2.22789
SHCBP1L SHC SH2-domain binding protein 1-like 2.22075
COQ8A coenzyme Q8A 2.21533
FHL5 four and a half LIM domains 5 2.21428
RALGDS ral guanine nucleotide dissociation stimulator 2.19766
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.19044
VPREB3 pre-B lymphocyte 3 2.1824
NPIPB6 nuclear pore complex interacting protein family, member B6 2.18166
IRGC immunity-related GTPase family, cinema 2.1813
DMTF1 cyclin D binding myb-like transcription factor 1 2.18019
HTN3 histatin 3 2.17864
SYTL2 synaptotagmin-like 2 2.16937
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.16746
AKAP4 A kinase (PRKA) anchor protein 4 2.16398
CATSPERG catsper channel auxiliary subunit gamma 2.1573
PRM2 protamine 2 2.15706
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.15254
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 2.14972
MCF2 MCF.2 cell line derived transforming sequence 2.14692
SIGLEC15 sialic acid binding Ig-like lectin 15 2.14648
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 2.13654
MROH7 maestro heat-like repeat family member 7 2.13282
RAB31 RAB31, member RAS oncogene family 2.12994
PRB3 proline-rich protein BstNI subfamily 3 2.12918
PCDHGA8 protocadherin gamma subfamily A, 8 2.12005
AQP5 aquaporin 5 2.11152
SPMAP2 sperm microtubule associated protein 2 2.11018
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2.10626
NTM neurotrimin 2.10597
H1-3 H1.3 linker histone, cluster member 2.10162
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.09917
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.09374
FGF13 fibroblast growth factor 13 2.09101
LCN2 lipocalin 2 2.08919
INSL4 insulin-like 4 (placenta) 2.08899
RBMXL2 RNA binding motif protein, X-linked-like 2 2.08659
NPY4R2 neuropeptide Y receptor Y4-2 2.08303
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.0826
AKAP3 A kinase (PRKA) anchor protein 3 2.07412
INF2 inverted formin, FH2 and WH2 domain containing 2.07375
EDIL3 EGF-like repeats and discoidin I-like domains 3 2.06964
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) 2.06522
BAG1 BCL2-associated athanogene 2.06015
CNRIP1 cannabinoid receptor interacting protein 1 2.06006
MRPL17 mitochondrial ribosomal protein L17 2.05775
CGRRF1 cell growth regulator with ring finger domain 1 2.05654
ANO1 anoctamin 1, calcium activated chloride channel 2.05616
EMCN endomucin 2.05329
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 2.05101
RASIP1 Ras interacting protein 1 2.05025
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.04798
SMR3B submaxillary gland androgen regulated protein 3B 2.04679
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 2.04493
ACTL7A actin-like 7A 2.0405
PXMP2 peroxisomal membrane protein 2, 22kDa 2.03768
ATP10A ATPase, class V, type 10A 2.03643
NECTIN4 nectin cell adhesion molecule 4 2.03595
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 2.02731
MAP7D3 MAP7 domain containing 3 2.02456
PLSCR2 phospholipid scramblase 2 2.02372
SH3BP1 SH3-domain binding protein 1 2.02186
MGLL monoglyceride lipase 2.01832
CYTL1 cytokine-like 1 2.01753
RHOBTB2 Rho-related BTB domain containing 2 2.01382
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 2.0131
NOL10 nucleolar protein 10 2.00733
CLDN18 claudin 18 2.00622
FTCD formimidoyltransferase cyclodeaminase 2.00573
ZNF385D zinc finger protein 385D 2.00045

decreased expression

Symbol Name Standardized Value
TCTN1 tectonic family member 1 -7.69707
LDHD lactate dehydrogenase D -6.96763
CCNB1 cyclin B1 -6.60554
KDM3A lysine (K)-specific demethylase 3A -5.35933
ARID5B AT rich interactive domain 5B (MRF1-like) -5.33446
SLC35F2 solute carrier family 35, member F2 -4.90819
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.62397
NGRN neugrin, neurite outgrowth associated -4.48434
THAP11 THAP domain containing 11 -4.38489
ADI1 acireductone dioxygenase 1 -4.37411
ZW10 zw10 kinetochore protein -4.20342
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.04776
TATDN2 TatD DNase domain containing 2 -3.7956
RFC2 replication factor C (activator 1) 2, 40kDa -3.78458
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.75925
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.72971
FBXL12 F-box and leucine-rich repeat protein 12 -3.71744
GTPBP8 GTP-binding protein 8 (putative) -3.69002
CCNB2 cyclin B2 -3.48439
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.37516
MCOLN1 mucolipin 1 -3.36087
HMG20B high mobility group 20B -3.28981
PRPF4 pre-mRNA processing factor 4 -3.283
KLHL21 kelch-like family member 21 -3.16132
CRELD2 cysteine-rich with EGF-like domains 2 -3.1314
RNF167 ring finger protein 167 -3.11889
PDLIM1 PDZ and LIM domain 1 -3.05481
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.01688
ALDOC aldolase C, fructose-bisphosphate -2.91923
MICALL1 MICAL-like 1 -2.90148
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.8876
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.8507
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) -2.80997
FKBP14 FK506 binding protein 14, 22 kDa -2.79431
UBE3C ubiquitin protein ligase E3C -2.78388
ENC1 ectodermal-neural cortex 1 (with BTB domain) -2.76191
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.67506
PDIA5 protein disulfide isomerase family A, member 5 -2.66112
DSG2 desmoglein 2 -2.62915
TCEAL4 transcription elongation factor A (SII)-like 4 -2.60538
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.53493
ZDHHC6 zinc finger, DHHC-type containing 6 -2.52918
CAB39 calcium binding protein 39 -2.52575
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.50558
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.48625
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 -2.4368
PPOX protoporphyrinogen oxidase -2.40155
GNAS GNAS complex locus -2.39596
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.38705
CHIC2 cysteine-rich hydrophobic domain 2 -2.36926
KIF14 kinesin family member 14 -2.36248
YME1L1 YME1-like 1 ATPase -2.35935
ACTL6A actin-like 6A -2.33877
SMG8 SMG8 nonsense mediated mRNA decay factor -2.33514
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.33015
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa -2.30609
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.29589
TM9SF3 transmembrane 9 superfamily member 3 -2.28529
ICE1 interactor of little elongation complex ELL subunit 1 -2.28394
TSKU tsukushi, small leucine rich proteoglycan -2.22365
USP39 ubiquitin specific peptidase 39 -2.22182
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.21233
FCHO1 FCH domain only 1 -2.20581
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.18417
USP6NL USP6 N-terminal like -2.1841
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit -2.17255
SPAG4 sperm associated antigen 4 -2.15279
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.14577
TMEM109 transmembrane protein 109 -2.13933
GDF15 growth differentiation factor 15 -2.1377
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -2.13045
DUSP14 dual specificity phosphatase 14 -2.11544
CANT1 calcium activated nucleotidase 1 -2.08903
WDR82 WD repeat domain 82 -2.08722
S100A9 S100 calcium binding protein A9 -2.06756
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -2.06096
KRT18 keratin 18, type I -2.04749
CDC42 cell division cycle 42 -2.03737