CRCGN012_HEPG2_24H:E10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description kynurenic-acid 2.64 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

96 genes differentially expressed following the CRCGN012_HEPG2_24H:E10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
UBQLN2 ubiquilin 2 6.50663
ADRB2 adrenoceptor beta 2, surface 4.90741
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.8684
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 4.818
CHN1 chimerin 1 4.7118
RPL39L ribosomal protein L39-like 4.61094
PRR15L proline rich 15-like 4.07876
E2F2 E2F transcription factor 2 4.0595
HOXA10 homeobox A10 4.05939
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.97156
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.94703
PLSCR1 phospholipid scramblase 1 3.59026
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 3.47117
HSPA1A heat shock 70kDa protein 1A 3.44111
EPHB2 EPH receptor B2 3.33217
PFKL phosphofructokinase, liver 3.21234
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 3.05372
IGFBP3 insulin-like growth factor binding protein 3 3.04175
INSIG1 insulin induced gene 1 3.00922
IFI44L interferon-induced protein 44-like 2.99382
NOSIP nitric oxide synthase interacting protein 2.99351
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.92653
IDE insulin-degrading enzyme 2.77719
PARP1 poly (ADP-ribose) polymerase 1 2.71107
ISG15 ISG15 ubiquitin-like modifier 2.70528
MX1 MX dynamin-like GTPase 1 2.70231
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.5984
SMAD3 SMAD family member 3 2.5919
DYNLT3 dynein, light chain, Tctex-type 3 2.57053
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.5218
IFI6 interferon, alpha-inducible protein 6 2.49912
IFI44 interferon-induced protein 44 2.48904
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.46961
CCNH cyclin H 2.43644
DENND2D DENN/MADD domain containing 2D 2.43464
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.40027
ATP11B ATPase, class VI, type 11B 2.34331
AOC1 amine oxidase, copper containing 1 2.29873
GRWD1 glutamate-rich WD repeat containing 1 2.27427
YIPF5 Yip1 domain family, member 5 2.2728
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.25444
PPARG peroxisome proliferator-activated receptor gamma 2.25175
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 2.22267
OASL 2'-5'-oligoadenylate synthetase-like 2.22167
IGFBP4 insulin-like growth factor binding protein 4 2.21089
GSTZ1 glutathione S-transferase zeta 1 2.2057
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.19681
OXCT1 3-oxoacid CoA transferase 1 2.19505
SH3D19 SH3 domain containing 19 2.12947
IFI35 interferon-induced protein 35 2.11228
ZC4H2 zinc finger, C4H2 domain containing 2.11078
JADE2 jade family PHD finger 2 2.10298
IL19 interleukin 19 2.08721
XAF1 XIAP associated factor 1 2.05629
CHEK2 checkpoint kinase 2 2.04888
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.04812
STK10 serine/threonine kinase 10 2.00696
LRP3 low density lipoprotein receptor-related protein 3 2.0065
HDGFL3 HDGF like 3 2.00461

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -7.21546
MAPK13 mitogen-activated protein kinase 13 -5.93474
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.81071
MRPS2 mitochondrial ribosomal protein S2 -5.21732
PCCB propionyl CoA carboxylase, beta polypeptide -5.12497
PCNA proliferating cell nuclear antigen -4.85029
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.74505
KDM3A lysine (K)-specific demethylase 3A -4.69831
DUSP6 dual specificity phosphatase 6 -4.3245
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.05005
NVL nuclear VCP-like -3.71463
TRIB3 tribbles pseudokinase 3 -3.64129
MAP7 microtubule-associated protein 7 -3.47399
TLCD3A TLC domain containing 3A -3.43306
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.23454
TCTN1 tectonic family member 1 -3.07203
RPIA ribose 5-phosphate isomerase A -3.03552
TES testin LIM domain protein -3.01259
PEG10 paternally expressed 10 -2.91671
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.67513
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.63629
EGF epidermal growth factor -2.59645
LDHD lactate dehydrogenase D -2.54086
CHMP4B charged multivesicular body protein 4B -2.48291
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.42879
ITGB1BP1 integrin beta 1 binding protein 1 -2.40455
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.35375
FCHO1 FCH domain only 1 -2.33804
GNAS GNAS complex locus -2.31796
DNM1L dynamin 1-like -2.26712
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.22735
NLRP4 NLR family, pyrin domain containing 4 -2.20117
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.19691
DENND5A DENN/MADD domain containing 5A -2.15657
TBC1D10C TBC1 domain family, member 10C -2.12909
OTOR otoraplin -2.09617