CRCGN012_HEPG2_24H:E11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description kynurenic-acid 1.32 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

105 genes differentially expressed following the CRCGN012_HEPG2_24H:E11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPL39L ribosomal protein L39-like 7.28999
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 6.749
CARMIL1 capping protein regulator and myosin 1 linker 1 6.17804
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.69848
ANO1 anoctamin 1, calcium activated chloride channel 4.44186
PRKCH protein kinase C, eta 4.03248
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.87873
LPAR2 lysophosphatidic acid receptor 2 3.69136
VGLL4 vestigial-like family member 4 3.53149
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 3.4277
LCN2 lipocalin 2 3.27906
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.00769
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 3.00047
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.91101
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.62888
WDTC1 WD and tetratricopeptide repeats 1 2.526
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 2.45605
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.42046
FKBP9 FK506 binding protein 9, 63 kDa 2.38222
MCM3 minichromosome maintenance complex component 3 2.22959
ZDHHC18 zinc finger, DHHC-type containing 18 2.1918
MXRA7 matrix-remodelling associated 7 2.17644
CHN1 chimerin 1 2.15951
ASCC3 activating signal cointegrator 1 complex subunit 3 2.10855
DDR1 discoidin domain receptor tyrosine kinase 1 2.10048
KIF2C kinesin family member 2C 2.01761

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -8.29328
FASTKD5 FAST kinase domains 5 -5.26573
GDF15 growth differentiation factor 15 -5.06682
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.76065
OXA1L oxidase (cytochrome c) assembly 1-like -4.20816
HYOU1 hypoxia up-regulated 1 -3.99559
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.88192
EGF epidermal growth factor -3.83681
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 -3.79451
UGDH UDP-glucose 6-dehydrogenase -3.65009
CCDC86 coiled-coil domain containing 86 -3.57227
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.48917
PEG10 paternally expressed 10 -3.3126
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.29151
ZMIZ1 zinc finger, MIZ-type containing 1 -3.2817
NUP85 nucleoporin 85kDa -3.20145
SLC35F2 solute carrier family 35, member F2 -3.14421
TXNL4B thioredoxin-like 4B -3.12979
CD320 CD320 molecule -3.11884
ACLY ATP citrate lyase -3.0986
HMG20B high mobility group 20B -3.08746
SNX11 sorting nexin 11 -2.98515
PDLIM1 PDZ and LIM domain 1 -2.96263
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.95542
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.90524
FBXL12 F-box and leucine-rich repeat protein 12 -2.89607
ZW10 zw10 kinetochore protein -2.84181
EAPP E2F-associated phosphoprotein -2.78454
EXT1 exostosin glycosyltransferase 1 -2.7523
DERA deoxyribose-phosphate aldolase (putative) -2.69366
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 -2.65354
RPS5 ribosomal protein S5 -2.55804
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.54441
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) -2.54274
ATF5 activating transcription factor 5 -2.48901
ZNF280D zinc finger protein 280D -2.45558
SSBP2 single-stranded DNA binding protein 2 -2.45008
NVL nuclear VCP-like -2.42193
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.40128
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -2.39084
MAPK13 mitogen-activated protein kinase 13 -2.38454
MBOAT7 membrane bound O-acyltransferase domain containing 7 -2.37961
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.36869
EIF5 eukaryotic translation initiation factor 5 -2.36388
PBX3 pre-B-cell leukemia homeobox 3 -2.35883
ZNF202 zinc finger protein 202 -2.35042
PLS1 plastin 1 -2.34189
METRN meteorin, glial cell differentiation regulator -2.30523
ADSL adenylosuccinate lyase -2.28707
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled -2.27945
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 -2.27778
CDC25B cell division cycle 25B -2.27092
NGRN neugrin, neurite outgrowth associated -2.25882
ACSM1 acyl-CoA synthetase medium-chain family member 1 -2.25616
RTN1 reticulon 1 -2.24073
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.21384
MAP2K5 mitogen-activated protein kinase kinase 5 -2.21278
WDR7 WD repeat domain 7 -2.21066
HOXA5 homeobox A5 -2.20165
ATG2B autophagy related 2B -2.16201
HOXA2 homeobox A2 -2.14351
COL4A5 collagen, type IV, alpha 5 -2.1292
DTWD1 DTW domain containing 1 -2.12449
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) -2.10663
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.10379
CD58 CD58 molecule -2.10309
TRPC6 transient receptor potential cation channel, subfamily C, member 6 -2.09078
RNF167 ring finger protein 167 -2.09023
MED17 mediator complex subunit 17 -2.08612
PDZK1 PDZ domain containing 1 -2.07303
KLHL9 kelch-like family member 9 -2.05779
IL26 interleukin 26 -2.05516
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -2.05444
USP3 ubiquitin specific peptidase 3 -2.04948
KIF13A kinesin family member 13A -2.02376
SNCAIP synuclein, alpha interacting protein -2.02108
ARMC7 armadillo repeat containing 7 -2.01657
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 -2.00729
SESN1 sestrin 1 -2.00357