CRCGN012_HEPG2_24H:E12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description kynurenic-acid 0.66 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

75 genes differentially expressed following the CRCGN012_HEPG2_24H:E12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 8.60616
STIMATE STIM activating enhancer 7.74462
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 7.31783
CSK c-src tyrosine kinase 5.49617
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.35355
UBQLN2 ubiquilin 2 5.00755
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.911
TAC4 tachykinin 4 (hemokinin) 4.49872
PPARG peroxisome proliferator-activated receptor gamma 4.48422
CCL2 chemokine (C-C motif) ligand 2 4.32443
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.25586
CHMP6 charged multivesicular body protein 6 4.20009
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.0282
SFTPB surfactant protein B 3.7099
PFKL phosphofructokinase, liver 3.59245
PEX11A peroxisomal biogenesis factor 11 alpha 3.40083
HSPA1A heat shock 70kDa protein 1A 3.30811
MAP7 microtubule-associated protein 7 3.20745
VGLL4 vestigial-like family member 4 3.11119
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.00383
DMTF1 cyclin D binding myb-like transcription factor 1 2.64565
TBXA2R thromboxane A2 receptor 2.64554
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.62025
MRPL18 mitochondrial ribosomal protein L18 2.51638
PTTG1IP pituitary tumor-transforming 1 interacting protein 2.50346
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 2.42232
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 2.32482
GNG10 guanine nucleotide binding protein (G protein), gamma 10 2.30193
LAG3 lymphocyte-activation gene 3 2.26915
EPHA3 EPH receptor A3 2.22205
ZNF528 zinc finger protein 528 2.21742
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.2166
LRRC32 leucine rich repeat containing 32 2.18529
PCDH12 protocadherin 12 2.17013
ZBTB24 zinc finger and BTB domain containing 24 2.16069
SCAF4 SR-related CTD-associated factor 4 2.15414
ZNF747 zinc finger protein 747 2.13307
PIEZO2 piezo-type mechanosensitive ion channel component 2 2.05453
PLA2G2D phospholipase A2, group IID 2.05029
GPATCH8 G patch domain containing 8 2.0234
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.02293
LIPG lipase, endothelial 2.01597

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -6.32172
CDC20 cell division cycle 20 -5.94691
KDM3A lysine (K)-specific demethylase 3A -5.18179
ZMIZ1 zinc finger, MIZ-type containing 1 -4.99851
LDHD lactate dehydrogenase D -4.76677
TUBB6 tubulin, beta 6 class V -4.75995
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.64182
CCNB2 cyclin B2 -4.55583
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.1958
HAT1 histone acetyltransferase 1 -4.10196
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -4.08662
BPHL biphenyl hydrolase-like (serine hydrolase) -4.08022
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.03183
PCCB propionyl CoA carboxylase, beta polypeptide -3.95772
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.82092
YME1L1 YME1-like 1 ATPase -3.61251
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.2948
CHMP4B charged multivesicular body protein 4B -3.27675
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.93564
CCNH cyclin H -2.84081
PEG10 paternally expressed 10 -2.56007
TXNRD1 thioredoxin reductase 1 -2.5537
EIF5 eukaryotic translation initiation factor 5 -2.54556
WASHC4 WASH complex subunit 4 -2.2727
ITGB1BP1 integrin beta 1 binding protein 1 -2.2367
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) -2.20589
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.08922
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.08151
HLA-DMA major histocompatibility complex, class II, DM alpha -2.07121
PSENEN presenilin enhancer gamma secretase subunit -2.03361
PPOX protoporphyrinogen oxidase -2.02168
TPBG trophoblast glycoprotein -2.0196
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -2.00786