CRCGN012_HEPG2_24H:E13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclohexanone 41.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN012_HEPG2_24H:E13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.02875
E2F2 E2F transcription factor 2 5.68771
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 5.09603
RPP38 ribonuclease P/MRP 38kDa subunit 4.23133
NOTCH1 notch 1 3.44589
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.40988
CSK c-src tyrosine kinase 3.39215
CCNF cyclin F 3.37888
WDTC1 WD and tetratricopeptide repeats 1 3.3048
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.22259
EPHA3 EPH receptor A3 3.1064
ANO1 anoctamin 1, calcium activated chloride channel 3.09977
MCM3 minichromosome maintenance complex component 3 3.05665
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.05073
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.99536
SATB1 SATB homeobox 1 2.96645
LYN LYN proto-oncogene, Src family tyrosine kinase 2.96168
CXCR4 chemokine (C-X-C motif) receptor 4 2.8018
CIAO3 cytosolic iron-sulfur assembly component 3 2.64507
CBR3 carbonyl reductase 3 2.581
PLSCR1 phospholipid scramblase 1 2.50291
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.48425
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.37128
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.34704
NTNG2 netrin G2 2.33539
HOXC5 homeobox C5 2.334
DYNLT3 dynein, light chain, Tctex-type 3 2.32602
STIMATE STIM activating enhancer 2.28695
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.2651
DNAI1 dynein, axonemal, intermediate chain 1 2.24398
GSTZ1 glutathione S-transferase zeta 1 2.21138
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.15517
RPL39L ribosomal protein L39-like 2.13327
VAV3 vav 3 guanine nucleotide exchange factor 2.11521
OR10J1 olfactory receptor, family 10, subfamily J, member 1 2.10274
BAD BCL2-associated agonist of cell death 2.08332
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.07884
MYOZ3 myozenin 3 2.06649
HOXC4 homeobox C4 2.04545
LTA lymphotoxin alpha 2.0304
LCN2 lipocalin 2 2.0202

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -7.4663
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.93513
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.1337
VAT1 vesicle amine transport 1 -3.99273
THAP11 THAP domain containing 11 -3.95334
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.65326
LDHD lactate dehydrogenase D -3.54713
CCNB1 cyclin B1 -3.37224
HSPB1 heat shock 27kDa protein 1 -3.10875
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.04649
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -3.04069
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.96529
TM9SF3 transmembrane 9 superfamily member 3 -2.6191
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.4499
FGFR4 fibroblast growth factor receptor 4 -2.418
MAP7 microtubule-associated protein 7 -2.40777
EIF5 eukaryotic translation initiation factor 5 -2.31801
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.28221
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.13495
NIT1 nitrilase 1 -2.10432
NVL nuclear VCP-like -2.08518
ECH1 enoyl CoA hydratase 1, peroxisomal -2.0743