CRCGN012_HEPG2_24H:E15 Gene Set
Genes
58 genes differentially expressed following the CRCGN012_HEPG2_24H:E15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
PHKG2
|
phosphorylase kinase, gamma 2 (testis)
|
6.9855
|
|
MYLK
|
myosin light chain kinase
|
6.66799
|
|
CBR3
|
carbonyl reductase 3
|
6.32012
|
|
CSK
|
c-src tyrosine kinase
|
5.59732
|
|
TIAM1
|
T-cell lymphoma invasion and metastasis 1
|
4.91172
|
|
TXNL4B
|
thioredoxin-like 4B
|
4.73055
|
|
CXCL2
|
chemokine (C-X-C motif) ligand 2
|
4.53103
|
|
PACSIN3
|
protein kinase C and casein kinase substrate in neurons 3
|
4.51231
|
|
LCN2
|
lipocalin 2
|
4.25457
|
|
HERC6
|
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
|
4.18085
|
|
SYNE2
|
spectrin repeat containing, nuclear envelope 2
|
4.05352
|
|
DYNLT3
|
dynein, light chain, Tctex-type 3
|
3.98802
|
|
CHAC1
|
ChaC glutathione-specific gamma-glutamylcyclotransferase 1
|
3.92113
|
|
DRAP1
|
DR1-associated protein 1 (negative cofactor 2 alpha)
|
3.2238
|
|
PRR15L
|
proline rich 15-like
|
3.08085
|
|
EVL
|
Enah/Vasp-like
|
2.88254
|
|
AGL
|
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
|
2.75848
|
|
E2F2
|
E2F transcription factor 2
|
2.50871
|
|
PTK2
|
protein tyrosine kinase 2
|
2.39386
|
|
FZD7
|
frizzled class receptor 7
|
2.35637
|
|
GPATCH8
|
G patch domain containing 8
|
2.26914
|
|
SHMT1
|
serine hydroxymethyltransferase 1 (soluble)
|
2.26448
|
|
MMP1
|
matrix metallopeptidase 1
|
2.14192
|
|
KIF20A
|
kinesin family member 20A
|
2.12427
|
|
SIRT3
|
sirtuin 3
|
2.10959
|
|
GATA3
|
GATA binding protein 3
|
2.08915
|
|
SEMA4D
|
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
|
2.05273
|
|
PLS1
|
plastin 1
|
2.0428
|
|
TBP
|
TATA box binding protein
|
2.02355
|
|
RNF40
|
ring finger protein 40, E3 ubiquitin protein ligase
|
2.01273
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
ST6GALNAC2
|
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
|
-5.83588
|
|
CCNB2
|
cyclin B2
|
-4.9067
|
|
HSD17B11
|
hydroxysteroid (17-beta) dehydrogenase 11
|
-4.6771
|
|
CCNB1
|
cyclin B1
|
-4.64306
|
|
DNM1L
|
dynamin 1-like
|
-4.20883
|
|
PPP2R3C
|
protein phosphatase 2, regulatory subunit B'', gamma
|
-3.73691
|
|
TM9SF2
|
transmembrane 9 superfamily member 2
|
-3.52241
|
|
SLC7A5
|
solute carrier family 7 (amino acid transporter light chain, L system), member 5
|
-3.49168
|
|
ZW10
|
zw10 kinetochore protein
|
-3.46675
|
|
ZNF586
|
zinc finger protein 586
|
-3.18068
|
|
TRIB3
|
tribbles pseudokinase 3
|
-3.15205
|
|
TARBP1
|
TAR (HIV-1) RNA binding protein 1
|
-3.03215
|
|
IARS2
|
isoleucyl-tRNA synthetase 2, mitochondrial
|
-2.9261
|
|
VAT1
|
vesicle amine transport 1
|
-2.77429
|
|
ISOC1
|
isochorismatase domain containing 1
|
-2.77372
|
|
RNF167
|
ring finger protein 167
|
-2.62001
|
|
UGDH
|
UDP-glucose 6-dehydrogenase
|
-2.59642
|
|
URGCP
|
upregulator of cell proliferation
|
-2.48507
|
|
MAPK13
|
mitogen-activated protein kinase 13
|
-2.47944
|
|
HMGCS1
|
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
|
-2.39224
|
|
SNX11
|
sorting nexin 11
|
-2.37718
|
|
GLOD4
|
glyoxalase domain containing 4
|
-2.33219
|
|
DUSP11
|
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
|
-2.27457
|
|
CNDP2
|
CNDP dipeptidase 2 (metallopeptidase M20 family)
|
-2.16321
|
|
LSM5
|
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
|
-2.10239
|
|
ADI1
|
acireductone dioxygenase 1
|
-2.07112
|
|
GNA11
|
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
|
-2.02424
|
|
TLCD3A
|
TLC domain containing 3A
|
-2.00012
|
