CRCGN012_HEPG2_24H:F02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description budesonide 10.68 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN012_HEPG2_24H:F02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CSK c-src tyrosine kinase 7.01411
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 6.42585
PNKP polynucleotide kinase 3'-phosphatase 6.21335
JADE2 jade family PHD finger 2 3.96575
RPP38 ribonuclease P/MRP 38kDa subunit 3.94845
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.74001
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.71301
ANO1 anoctamin 1, calcium activated chloride channel 3.58461
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.41292
MYLK myosin light chain kinase 3.37362
H2BC12 H2B clustered histone 12 3.36641
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.11345
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.10184
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.95934
NOSIP nitric oxide synthase interacting protein 2.93214
NOTCH1 notch 1 2.87437
DDIT4 DNA-damage-inducible transcript 4 2.75164
ADRB2 adrenoceptor beta 2, surface 2.67627
E2F2 E2F transcription factor 2 2.67395
CYCS cytochrome c, somatic 2.50079
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.47471
PTOV1 prostate tumor overexpressed 1 2.34669
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.31385
KIFBP kinesin family binding protein 2.14419
BZW2 basic leucine zipper and W2 domains 2 2.10048
GPER1 G protein-coupled estrogen receptor 1 2.08515

decreased expression

Symbol Name Standardized Value
NT5DC2 5'-nucleotidase domain containing 2 -5.94498
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.83861
PCNA proliferating cell nuclear antigen -5.76657
CCNB1 cyclin B1 -4.50979
ARID5B AT rich interactive domain 5B (MRF1-like) -4.16295
RBM15B RNA binding motif protein 15B -3.6774
RFC2 replication factor C (activator 1) 2, 40kDa -3.66164
KDM3A lysine (K)-specific demethylase 3A -3.58386
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.47003
CDC20 cell division cycle 20 -3.44515
COG2 component of oligomeric golgi complex 2 -3.43145
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.39961
DSG2 desmoglein 2 -3.32853
MAP7 microtubule-associated protein 7 -3.2427
MRPS2 mitochondrial ribosomal protein S2 -3.13989
DNM1L dynamin 1-like -3.11473
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.08209
ADI1 acireductone dioxygenase 1 -2.84321
LYPLA1 lysophospholipase I -2.66207
MAPK13 mitogen-activated protein kinase 13 -2.64839
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -2.50827
LDHD lactate dehydrogenase D -2.5035
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.45101
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.43963
EDN1 endothelin 1 -2.41207
GNAS GNAS complex locus -2.39575
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.38095
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) -2.3779
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.35969
ZW10 zw10 kinetochore protein -2.32268
KIAA1614 KIAA1614 -2.30014
SOX4 SRY (sex determining region Y)-box 4 -2.22294
SCAND1 SCAN domain containing 1 -2.18955
IFRD2 interferon-related developmental regulator 2 -2.18685
ANXA1 annexin A1 -2.15359
PRPF4 pre-mRNA processing factor 4 -2.14155
GJC2 gap junction protein, gamma 2, 47kDa -2.0911
CD58 CD58 molecule -2.07501
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough -2.05619
TRIB2 tribbles pseudokinase 2 -2.01506