CRCGN012_HEPG2_24H:F03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description budesonide 5.34 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN012_HEPG2_24H:F03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 7.34482
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.93734
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.67812
CSK c-src tyrosine kinase 5.73292
PHKA1 phosphorylase kinase, alpha 1 (muscle) 5.07561
RPL39L ribosomal protein L39-like 4.71658
PRKCH protein kinase C, eta 3.93343
C2CD2 C2 calcium-dependent domain containing 2 3.85848
NOTCH1 notch 1 3.77021
GRWD1 glutamate-rich WD repeat containing 1 3.71995
NMU neuromedin U 3.58701
KLHL21 kelch-like family member 21 3.56973
KIFBP kinesin family binding protein 3.36006
LCN2 lipocalin 2 2.87168
CARMIL1 capping protein regulator and myosin 1 linker 1 2.86316
CXCR4 chemokine (C-X-C motif) receptor 4 2.832
RPP38 ribonuclease P/MRP 38kDa subunit 2.76831
DDIT4 DNA-damage-inducible transcript 4 2.75378
LPAR2 lysophosphatidic acid receptor 2 2.72767
ABHD6 abhydrolase domain containing 6 2.70117
CCL2 chemokine (C-C motif) ligand 2 2.69889
FCHO1 FCH domain only 1 2.66188
CYCS cytochrome c, somatic 2.62949
STK10 serine/threonine kinase 10 2.61897
MEST mesoderm specific transcript 2.6132
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.60204
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.5765
OXCT1 3-oxoacid CoA transferase 1 2.51651
ANO1 anoctamin 1, calcium activated chloride channel 2.49266
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 2.48955
GSTZ1 glutathione S-transferase zeta 1 2.42447
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.34522
PCNA proliferating cell nuclear antigen 2.33196
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.31134
INSIG1 insulin induced gene 1 2.30532
TIAM1 T-cell lymphoma invasion and metastasis 1 2.24785
ADRB2 adrenoceptor beta 2, surface 2.2468
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.2127
HOMER2 homer scaffolding protein 2 2.07413
E2F2 E2F transcription factor 2 2.03402
PXMP2 peroxisomal membrane protein 2, 22kDa 2.01129

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -6.37821
NGRN neugrin, neurite outgrowth associated -6.31258
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.96655
SPAG4 sperm associated antigen 4 -3.56504
CDC20 cell division cycle 20 -3.54435
CCNB2 cyclin B2 -3.37846
SNX11 sorting nexin 11 -3.22841
ZNF586 zinc finger protein 586 -3.22629
C2CD5 C2 calcium-dependent domain containing 5 -2.95424
CD320 CD320 molecule -2.72991
RPS5 ribosomal protein S5 -2.70779
FBXO7 F-box protein 7 -2.52675
SLC35F2 solute carrier family 35, member F2 -2.34674
FOXO4 forkhead box O4 -2.29355
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -2.28261
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.21599
LOC124907782 dual specificity protein phosphatase 22 -2.09999
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.05004