CRCGN012_HEPG2_24H:F04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description budesonide 2.67 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN012_HEPG2_24H:F04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 5.50297
CHN1 chimerin 1 4.7399
CIAO3 cytosolic iron-sulfur assembly component 3 4.41622
ATP11B ATPase, class VI, type 11B 4.2519
BTK Bruton agammaglobulinemia tyrosine kinase 3.99471
NMU neuromedin U 3.94713
CCL2 chemokine (C-C motif) ligand 2 3.77717
ADGRE5 adhesion G protein-coupled receptor E5 3.55699
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.40577
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.13697
RPP38 ribonuclease P/MRP 38kDa subunit 3.13616
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.0552
PPARG peroxisome proliferator-activated receptor gamma 2.99304
KLHL21 kelch-like family member 21 2.71033
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.65861
EXOSC4 exosome component 4 2.48721
E2F2 E2F transcription factor 2 2.46072
DDIT4 DNA-damage-inducible transcript 4 2.45328
NOSIP nitric oxide synthase interacting protein 2.45206
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.45075
SPRED2 sprouty-related, EVH1 domain containing 2 2.42629
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.4221
GATA3 GATA binding protein 3 2.41211
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.35609
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.34762
RAB21 RAB21, member RAS oncogene family 2.34638
ANO1 anoctamin 1, calcium activated chloride channel 2.18659
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.17581
GTPBP8 GTP-binding protein 8 (putative) 2.0638

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -3.69896
PCCB propionyl CoA carboxylase, beta polypeptide -3.68857
RFC2 replication factor C (activator 1) 2, 40kDa -3.67299
TRIB3 tribbles pseudokinase 3 -3.38993
HMG20B high mobility group 20B -3.26247
ZNF586 zinc finger protein 586 -3.14304
FAIM Fas apoptotic inhibitory molecule -3.14021
PCNA proliferating cell nuclear antigen -3.05329
ANKRD10 ankyrin repeat domain 10 -3.01768
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.7737
CCNB2 cyclin B2 -2.54328
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.44149
CDC25B cell division cycle 25B -2.41296
COG7 component of oligomeric golgi complex 7 -2.40769
EIF5 eukaryotic translation initiation factor 5 -2.38321
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.36239
FGFR4 fibroblast growth factor receptor 4 -2.31773
SOX4 SRY (sex determining region Y)-box 4 -2.31037
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.3056
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.28861
RNFT1-DT RNFT1 divergent transcript -2.28308
CTNND1 catenin (cadherin-associated protein), delta 1 -2.15901
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.04574