CRCGN012_HEPG2_24H:F05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description budesonide 1.34 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN012_HEPG2_24H:F05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 6.63442
LYN LYN proto-oncogene, Src family tyrosine kinase 4.12251
CYCS cytochrome c, somatic 3.89749
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.76951
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.36251
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.35167
ABHD6 abhydrolase domain containing 6 3.3467
PRR15L proline rich 15-like 3.26663
UBQLN2 ubiquilin 2 3.25241
EVL Enah/Vasp-like 3.23589
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.96128
PPARG peroxisome proliferator-activated receptor gamma 2.95755
DDIT4 DNA-damage-inducible transcript 4 2.77876
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.77843
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.75444
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.6588
CSK c-src tyrosine kinase 2.58535
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.54274
ZFP36 ZFP36 ring finger protein 2.45719
TUBB6 tubulin, beta 6 class V 2.45561
CHMP6 charged multivesicular body protein 6 2.41974
LCN2 lipocalin 2 2.41805
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.39478
LSR lipolysis stimulated lipoprotein receptor 2.33331
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.3134
LPAR2 lysophosphatidic acid receptor 2 2.30218
SMIM40 small integral membrane protein 40 2.20569
SHB Src homology 2 domain containing adaptor protein B 2.20211
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.20132
EXOSC4 exosome component 4 2.15955
GTPBP8 GTP-binding protein 8 (putative) 2.15639
PFKL phosphofructokinase, liver 2.08235
KIFBP kinesin family binding protein 2.04388
PUF60 poly-U binding splicing factor 60KDa 2.04194
TEFM transcription elongation factor, mitochondrial 2.0094
ZNF589 zinc finger protein 589 2.00598

decreased expression

Symbol Name Standardized Value
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.54023
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.34159
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -6.18818
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.88781
MAPK13 mitogen-activated protein kinase 13 -4.78649
SLC35F2 solute carrier family 35, member F2 -4.62248
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.65289
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.42927
ADI1 acireductone dioxygenase 1 -3.40588
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.36676
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.34306
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.32323
FBXL12 F-box and leucine-rich repeat protein 12 -2.99283
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.64864
CCNB1 cyclin B1 -2.50795
GNAS GNAS complex locus -2.49519
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.46434
TBCB tubulin folding cofactor B -2.35821
NRIP1 nuclear receptor interacting protein 1 -2.34728
RNF167 ring finger protein 167 -2.15861
SOX4 SRY (sex determining region Y)-box 4 -2.14903
PCNA proliferating cell nuclear antigen -2.1051