CRCGN012_HEPG2_24H:F09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN012_HEPG2_24H:F09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PNKP polynucleotide kinase 3'-phosphatase 7.4075
CSK c-src tyrosine kinase 4.74574
STIMATE STIM activating enhancer 4.55958
AMDHD2 amidohydrolase domain containing 2 4.02258
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.75889
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.71922
ATP11B ATPase, class VI, type 11B 3.70073
CBR3 carbonyl reductase 3 3.60209
BACE2 beta-site APP-cleaving enzyme 2 3.58378
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.48539
MYLK myosin light chain kinase 3.4745
C2CD2 C2 calcium-dependent domain containing 2 3.4148
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.35214
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.15324
NOTCH1 notch 1 3.08506
VGLL4 vestigial-like family member 4 2.9823
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.80342
KLHL21 kelch-like family member 21 2.77398
RPL39L ribosomal protein L39-like 2.74573
SMIM40 small integral membrane protein 40 2.73778
HOXA10 homeobox A10 2.73684
EPHA3 EPH receptor A3 2.62638
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.5857
ABHD6 abhydrolase domain containing 6 2.49691
PTOV1 prostate tumor overexpressed 1 2.40997
PRR15L proline rich 15-like 2.31058
FBLN5 fibulin 5 2.30297
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.28609
RUVBL2 RuvB-like AAA ATPase 2 2.23821
LOC122526780 uncharacterized LOC122526780 2.21912
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.17705
MAP7 microtubule-associated protein 7 2.17508
CCNA1 cyclin A1 2.15549
ANO1 anoctamin 1, calcium activated chloride channel 2.12746
GPATCH8 G patch domain containing 8 2.12543
TIAM1 T-cell lymphoma invasion and metastasis 1 2.11647
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.06986
ZFTA zinc finger translocation associated 2.05071
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.04423

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.31956
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.51374
PCNA proliferating cell nuclear antigen -6.24783
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.51503
RPIA ribose 5-phosphate isomerase A -3.84021
UGDH UDP-glucose 6-dehydrogenase -3.82935
HSPB1 heat shock 27kDa protein 1 -3.79716
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.67424
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.66513
TUBB6 tubulin, beta 6 class V -3.57813
ADI1 acireductone dioxygenase 1 -3.53897
RFC2 replication factor C (activator 1) 2, 40kDa -3.23562
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.22162
KTN1 kinectin 1 (kinesin receptor) -3.06744
BPHL biphenyl hydrolase-like (serine hydrolase) -3.06451
MAPK13 mitogen-activated protein kinase 13 -2.99451
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.70246
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.56595
SCAND1 SCAN domain containing 1 -2.36648
PRPF4 pre-mRNA processing factor 4 -2.25834
NVL nuclear VCP-like -2.23573
ZMIZ1 zinc finger, MIZ-type containing 1 -2.18032
SNX11 sorting nexin 11 -2.02296
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.02007