CRCGN012_HEPG2_24H:F15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description adipamide 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN012_HEPG2_24H:F15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 8.52517
MYLK myosin light chain kinase 5.22135
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.99469
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.76417
CXCL2 chemokine (C-X-C motif) ligand 2 4.63095
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.49531
PHKG2 phosphorylase kinase, gamma 2 (testis) 4.39147
PRR15L proline rich 15-like 4.35237
FOXO4 forkhead box O4 3.86306
ADGRE5 adhesion G protein-coupled receptor E5 3.85747
ABHD6 abhydrolase domain containing 6 3.7582
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.9576
MOK MOK protein kinase 2.91839
GSTZ1 glutathione S-transferase zeta 1 2.91709
SETD1A SET domain containing 1A 2.7685
PMM2 phosphomannomutase 2 2.70329
CNPY4 canopy FGF signaling regulator 4 2.65955
TIAM1 T-cell lymphoma invasion and metastasis 1 2.64939
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.45255
HYOU1 hypoxia up-regulated 1 2.44354
GPER1 G protein-coupled estrogen receptor 1 2.43236
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.42093
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.40755
FAM110D family with sequence similarity 110, member D 2.39549
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.21637
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 2.20157
NOSIP nitric oxide synthase interacting protein 2.15779
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 2.14012
ADGRD2 adhesion G protein-coupled receptor D2 2.13675
ADAMTSL2 ADAMTS-like 2 2.12982
IQCC IQ motif containing C 2.12025
PCDHA10 protocadherin alpha 10 2.11402
DES desmin 2.10709
ZNF646 zinc finger protein 646 2.10446
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.07004
WIF1 WNT inhibitory factor 1 2.05255
TEX10 testis expressed 10 2.04951
ST20-MTHFS ST20-MTHFS readthrough 2.0428
NMU neuromedin U 2.02392
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 2.02378
FAM13A family with sequence similarity 13, member A 2.019
UPK3B uroplakin 3B 2.01036
PTPRS protein tyrosine phosphatase, receptor type, S 2.0029
TMEM41B transmembrane protein 41B 2.00251

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.6237
CDC20 cell division cycle 20 -4.6139
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.57617
VAT1 vesicle amine transport 1 -4.5332
DNM1L dynamin 1-like -4.31485
LDHD lactate dehydrogenase D -4.30008
ADI1 acireductone dioxygenase 1 -4.25742
KDM3A lysine (K)-specific demethylase 3A -4.25224
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.95455
GOLT1B golgi transport 1B -3.93637
TRIB3 tribbles pseudokinase 3 -3.81486
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.59882
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.39045
FBXL12 F-box and leucine-rich repeat protein 12 -2.94634
OXA1L oxidase (cytochrome c) assembly 1-like -2.91226
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.88087
MVP major vault protein -2.79338
NRIP1 nuclear receptor interacting protein 1 -2.61102
MYL9 myosin, light chain 9, regulatory -2.41875
SSBP2 single-stranded DNA binding protein 2 -2.36969
KLHL21 kelch-like family member 21 -2.27453
RECQL RecQ helicase-like -2.17954
RNF19B ring finger protein 19B -2.10008
XAB2 XPA binding protein 2 -2.09911
XKR8 XK, Kell blood group complex subunit-related family, member 8 -2.06834
NR1D1 nuclear receptor subfamily 1, group D, member 1 -2.04583
CLEC2D C-type lectin domain family 2, member D -2.02235
ZMIZ1 zinc finger, MIZ-type containing 1 -2.0147
SLC35F2 solute carrier family 35, member F2 -2.00898