CRCGN012_HEPG2_24H:F19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description c.i. acid red 114 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

86 genes differentially expressed following the CRCGN012_HEPG2_24H:F19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ALDOC aldolase C, fructose-bisphosphate 7.90198
PPARG peroxisome proliferator-activated receptor gamma 6.76814
CSK c-src tyrosine kinase 6.47145
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 6.31092
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.32257
PNKP polynucleotide kinase 3'-phosphatase 4.58898
ANO1 anoctamin 1, calcium activated chloride channel 3.98078
AMDHD2 amidohydrolase domain containing 2 3.7616
SNAP25 synaptosomal-associated protein, 25kDa 3.63608
NFIL3 nuclear factor, interleukin 3 regulated 3.55505
CDC45 cell division cycle 45 3.43511
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.39078
CCDC92 coiled-coil domain containing 92 3.37441
CXCL2 chemokine (C-X-C motif) ligand 2 3.3035
CBR3 carbonyl reductase 3 3.27755
HOXA10 homeobox A10 3.21583
TIAM1 T-cell lymphoma invasion and metastasis 1 3.2012
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.16455
ADRB2 adrenoceptor beta 2, surface 3.1513
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.05114
LOC122526780 uncharacterized LOC122526780 3.02161
DDIT4 DNA-damage-inducible transcript 4 2.98963
MYLK myosin light chain kinase 2.98897
ADGRE5 adhesion G protein-coupled receptor E5 2.88409
PRKCH protein kinase C, eta 2.81522
DYNLT3 dynein, light chain, Tctex-type 3 2.81309
RPL39L ribosomal protein L39-like 2.77439
PFKL phosphofructokinase, liver 2.75291
CCL2 chemokine (C-C motif) ligand 2 2.70149
UFM1 ubiquitin-fold modifier 1 2.69218
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.68456
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.68356
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.67421
PRR15L proline rich 15-like 2.60379
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.59864
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.51177
GSTZ1 glutathione S-transferase zeta 1 2.50246
TRIB3 tribbles pseudokinase 3 2.47019
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.42797
TCTN1 tectonic family member 1 2.36137
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 2.28596
SOAT2 sterol O-acyltransferase 2 2.28518
MTERF3 mitochondrial transcription termination factor 3 2.25006
H2BC12 H2B clustered histone 12 2.23959
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.15417
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.15044
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.12736
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.10601
GRAMD4 GRAM domain containing 4 2.0562
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.04935
NOSIP nitric oxide synthase interacting protein 2.03761

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.82589
RPN1 ribophorin I -7.13966
LDHD lactate dehydrogenase D -6.4129
CCNB2 cyclin B2 -6.07546
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.79733
TP53BP2 tumor protein p53 binding protein 2 -4.09209
CCDC86 coiled-coil domain containing 86 -4.02341
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.52287
CDC20 cell division cycle 20 -3.41694
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.36273
RPIA ribose 5-phosphate isomerase A -3.31783
NCK1 NCK adaptor protein 1 -3.28861
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.09556
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.05067
DSG2 desmoglein 2 -2.98659
COPG1 coatomer protein complex, subunit gamma 1 -2.97862
OXA1L oxidase (cytochrome c) assembly 1-like -2.94515
CD320 CD320 molecule -2.8669
PCCB propionyl CoA carboxylase, beta polypeptide -2.82292
PRPF4 pre-mRNA processing factor 4 -2.70021
CCNB1 cyclin B1 -2.56181
MYCBP MYC binding protein -2.49032
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.35628
RTN3 reticulon 3 -2.33551
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.27287
YME1L1 YME1-like 1 ATPase -2.26385
CTSL cathepsin L -2.22625
RAI14 retinoic acid induced 14 -2.21502
FBXO46 F-box protein 46 -2.18372
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 -2.16521
DMAP1 DNA methyltransferase 1 associated protein 1 -2.15996
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.03833
ARMC1 armadillo repeat containing 1 -2.03811
RFC2 replication factor C (activator 1) 2, 40kDa -2.02703
SNX11 sorting nexin 11 -2.02359