CRCGN012_HEPG2_24H:F20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description c.i. acid red 114 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN012_HEPG2_24H:F20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 6.33417
TBXA2R thromboxane A2 receptor 5.24053
CCL2 chemokine (C-C motif) ligand 2 4.97736
AMDHD2 amidohydrolase domain containing 2 4.12934
ALDOC aldolase C, fructose-bisphosphate 3.99693
MAMLD1 mastermind-like domain containing 1 3.75311
STIMATE STIM activating enhancer 3.6292
PLS1 plastin 1 3.58518
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.4083
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.4075
CSK c-src tyrosine kinase 3.27909
E2F2 E2F transcription factor 2 3.26417
RPP38 ribonuclease P/MRP 38kDa subunit 3.19788
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.19333
SQOR sulfide quinone oxidoreductase 3.15665
PPARG peroxisome proliferator-activated receptor gamma 3.15228
C2CD2 C2 calcium-dependent domain containing 2 3.14184
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.12095
MOK MOK protein kinase 3.1034
CIAO3 cytosolic iron-sulfur assembly component 3 3.08095
ADAM10 ADAM metallopeptidase domain 10 2.95009
MTERF3 mitochondrial transcription termination factor 3 2.93376
NOTCH1 notch 1 2.85182
EPHB2 EPH receptor B2 2.84728
CCNA1 cyclin A1 2.55272
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.53325
BPHL biphenyl hydrolase-like (serine hydrolase) 2.52158
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.51939
CDC45 cell division cycle 45 2.46568
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.4593
SOAT2 sterol O-acyltransferase 2 2.43824
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.2839
HOXA10 homeobox A10 2.27991
MAD2L1BP MAD2L1 binding protein 2.23787
GALE UDP-galactose-4-epimerase 2.16966
NSUN3 NOP2/Sun domain family, member 3 2.15846
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.09395
NMI N-myc (and STAT) interactor 2.07783
DIPK1A divergent protein kinase domain 1A 2.05325
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.04094
TCTN1 tectonic family member 1 2.00134

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -8.50672
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.16542
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.88932
OXA1L oxidase (cytochrome c) assembly 1-like -3.79783
MRPS2 mitochondrial ribosomal protein S2 -3.65086
ARID5B AT rich interactive domain 5B (MRF1-like) -3.58673
KDM3A lysine (K)-specific demethylase 3A -3.26729
ZDHHC6 zinc finger, DHHC-type containing 6 -3.21472
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.20829
STMN1 stathmin 1 -3.01784
ITGB1BP1 integrin beta 1 binding protein 1 -2.98605
UBE3C ubiquitin protein ligase E3C -2.77597
VAT1 vesicle amine transport 1 -2.64512
CTSD cathepsin D -2.59689
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.40968
ZMIZ1 zinc finger, MIZ-type containing 1 -2.32908
TCERG1 transcription elongation regulator 1 -2.27253
PCNA proliferating cell nuclear antigen -2.26948
EIF5 eukaryotic translation initiation factor 5 -2.20988
MAPK13 mitogen-activated protein kinase 13 -2.20779
FKBP4 FK506 binding protein 4, 59kDa -2.04407