CRCGN012_HEPG2_24H:F21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description c.i. acid red 114 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN012_HEPG2_24H:F21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 7.87626
MYLK myosin light chain kinase 6.99485
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.20547
STK10 serine/threonine kinase 10 6.10484
MCOLN1 mucolipin 1 5.35674
TIAM1 T-cell lymphoma invasion and metastasis 1 4.68706
UBQLN2 ubiquilin 2 4.33137
LCN2 lipocalin 2 4.19652
CARMIL1 capping protein regulator and myosin 1 linker 1 4.19472
CYCS cytochrome c, somatic 4.17572
SNAP25 synaptosomal-associated protein, 25kDa 4.06172
SLC75A1 solute carrier family 75 member 1 3.19876
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.07163
NOTCH1 notch 1 3.03859
ANO10 anoctamin 10 3.01575
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.9276
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.85347
CCNF cyclin F 2.8472
CSK c-src tyrosine kinase 2.84485
LOC122526780 uncharacterized LOC122526780 2.80997
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.7538
MEF2C myocyte enhancer factor 2C 2.64615
PFKL phosphofructokinase, liver 2.51139
MTERF3 mitochondrial transcription termination factor 3 2.5033
ALDOC aldolase C, fructose-bisphosphate 2.50261
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.31565
CCDC85B coiled-coil domain containing 85B 2.28605
PTCH2 patched 2 2.2175
MOGAT1 monoacylglycerol O-acyltransferase 1 2.21112
PITPNB phosphatidylinositol transfer protein, beta 2.1677
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.16621
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.13593
PPARG peroxisome proliferator-activated receptor gamma 2.1114
TMOD1 tropomodulin 1 2.097
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.05231
FXYD7 FXYD domain containing ion transport regulator 7 2.04325
DENR density-regulated protein 2.03832
LSR lipolysis stimulated lipoprotein receptor 2.03193
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.03138
DENND2A DENN/MADD domain containing 2A 2.00322

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -6.93025
CDC20 cell division cycle 20 -5.06009
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.4883
DSG2 desmoglein 2 -4.27316
TRIB3 tribbles pseudokinase 3 -4.1407
MAP7 microtubule-associated protein 7 -3.76739
EGF epidermal growth factor -3.73388
PCCB propionyl CoA carboxylase, beta polypeptide -3.72643
CCNB2 cyclin B2 -3.47092
OXA1L oxidase (cytochrome c) assembly 1-like -3.39395
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.36917
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -3.36464
FGFR4 fibroblast growth factor receptor 4 -3.33377
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.19233
NT5DC2 5'-nucleotidase domain containing 2 -3.16922
LYPLA1 lysophospholipase I -2.90545
NCK1 NCK adaptor protein 1 -2.6991
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.69438
TCERG1 transcription elongation regulator 1 -2.56495
STMN1 stathmin 1 -2.54089
HMG20B high mobility group 20B -2.53084
PRPF4 pre-mRNA processing factor 4 -2.52006
ATG14 autophagy related 14 -2.49504
SNX11 sorting nexin 11 -2.44096
RLN2 relaxin 2 -2.15852
MSH6 mutS homolog 6 -2.13065
ZNF586 zinc finger protein 586 -2.10717
EXOC5 exocyst complex component 5 -2.10561
DHRS9 dehydrogenase/reductase (SDR family) member 9 -2.05226
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.04444