CRCGN012_HEPG2_24H:G04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description rotenone 5.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

654 genes differentially expressed following the CRCGN012_HEPG2_24H:G04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KIFBP kinesin family binding protein 9.3629
TIMP2 TIMP metallopeptidase inhibitor 2 8.86944
BZW2 basic leucine zipper and W2 domains 2 8.06188
TXNRD1 thioredoxin reductase 1 7.87217
INPP1 inositol polyphosphate-1-phosphatase 7.54282
CDPF1 cysteine-rich, DPF motif domain containing 1 7.53231
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 7.29208
ANO1 anoctamin 1, calcium activated chloride channel 6.97393
FOSL1 FOS-like antigen 1 6.94762
SQOR sulfide quinone oxidoreductase 6.66909
MVP major vault protein 6.40121
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.87895
IER3 immediate early response 3 5.78617
EGR1 early growth response 1 5.7815
TESK1 testis-specific kinase 1 5.7469
STX1A syntaxin 1A (brain) 5.71169
NPC1 Niemann-Pick disease, type C1 5.51088
ZFP36 ZFP36 ring finger protein 5.50382
SQSTM1 sequestosome 1 5.49445
ISOC1 isochorismatase domain containing 1 5.31248
IGFBP3 insulin-like growth factor binding protein 3 5.2444
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.08909
PHKA1 phosphorylase kinase, alpha 1 (muscle) 5.05675
PPARG peroxisome proliferator-activated receptor gamma 4.78826
MYC v-myc avian myelocytomatosis viral oncogene homolog 4.77628
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 4.75512
PNKP polynucleotide kinase 3'-phosphatase 4.73811
UBQLN2 ubiquilin 2 4.70481
KLHL21 kelch-like family member 21 4.68897
SMAD3 SMAD family member 3 4.66813
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.65407
IL4R interleukin 4 receptor 4.65047
MICALL1 MICAL-like 1 4.58119
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.54859
NANOS3 nanos homolog 3 (Drosophila) 4.46632
SLC35F2 solute carrier family 35, member F2 4.45869
TRIB1 tribbles pseudokinase 1 4.31805
LCN2 lipocalin 2 4.12639
ACOT9 acyl-CoA thioesterase 9 4.10538
NPDC1 neural proliferation, differentiation and control, 1 4.09694
C2CD2 C2 calcium-dependent domain containing 2 4.09488
NOTCH1 notch 1 4.08119
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.97946
MBNL1 muscleblind-like splicing regulator 1 3.83165
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.83152
SOX4 SRY (sex determining region Y)-box 4 3.79563
SHB Src homology 2 domain containing adaptor protein B 3.74968
FHL2 four and a half LIM domains 2 3.74527
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.74028
TOMM34 translocase of outer mitochondrial membrane 34 3.69153
ADRB2 adrenoceptor beta 2, surface 3.66408
MBNL2 muscleblind-like splicing regulator 2 3.6477
ADGRG1 adhesion G protein-coupled receptor G1 3.63938
SARS1 seryl-tRNA synthetase 1 3.63793
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 3.62727
RALB v-ral simian leukemia viral oncogene homolog B 3.60896
CASC3 cancer susceptibility candidate 3 3.59337
STK10 serine/threonine kinase 10 3.58882
CSNK1E casein kinase 1, epsilon 3.56175
CAB39 calcium binding protein 39 3.55952
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.53766
TICAM1 toll-like receptor adaptor molecule 1 3.5299
CCL2 chemokine (C-C motif) ligand 2 3.50014
TP53BP2 tumor protein p53 binding protein 2 3.49773
DUSP6 dual specificity phosphatase 6 3.48781
SUN2 Sad1 and UNC84 domain containing 2 3.48602
CNPY3 canopy FGF signaling regulator 3 3.48156
SH3GLB1 SH3-domain GRB2-like endophilin B1 3.4722
CHIC2 cysteine-rich hydrophobic domain 2 3.45257
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 3.44435
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.42121
GTPBP2 GTP binding protein 2 3.4112
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 3.39618
ALAS1 5'-aminolevulinate synthase 1 3.37214
BIRC2 baculoviral IAP repeat containing 2 3.3692
ZYX zyxin 3.3621
PRKCD protein kinase C, delta 3.35675
YIPF3 Yip1 domain family, member 3 3.3476
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 3.33797
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.31388
DDIT4 DNA-damage-inducible transcript 4 3.29679
PDGFA platelet-derived growth factor alpha polypeptide 3.26748
AARS1 alanyl-tRNA synthetase 1 3.25393
DNM1L dynamin 1-like 3.25375
JOSD1 Josephin domain containing 1 3.23783
CLTB clathrin, light chain B 3.21712
EPN2 epsin 2 3.18834
PRKCH protein kinase C, eta 3.18797
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 3.18449
EPHA2 EPH receptor A2 3.17004
OSGIN2 oxidative stress induced growth inhibitor family member 2 3.15805
SOCS2 suppressor of cytokine signaling 2 3.15739
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 3.14905
CERS6 ceramide synthase 6 3.12628
CAMTA2 calmodulin binding transcription activator 2 3.12591
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.12551
PPARD peroxisome proliferator-activated receptor delta 3.11064
PCDHB11 protocadherin beta 11 3.09301
MBTD1 mbt domain containing 1 3.07416
BACE2 beta-site APP-cleaving enzyme 2 3.07207
TES testin LIM domain protein 3.06626
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 3.05857
MYH9 myosin, heavy chain 9, non-muscle 3.04034
FCHO1 FCH domain only 1 3.02586
RHOC ras homolog family member C 2.99795
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 2.99098
SYNGAP1 synaptic Ras GTPase activating protein 1 2.99023
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 2.98584
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.96776
TMEM184B transmembrane protein 184B 2.95893
NMU neuromedin U 2.9503
RTCA RNA 3'-terminal phosphate cyclase 2.94095
MACF1 microtubule-actin crosslinking factor 1 2.91879
NUP58 nucleoporin 58 2.91134
GRB10 growth factor receptor-bound protein 10 2.89339
TENT4A terminal nucleotidyltransferase 4A 2.8914
CYCS cytochrome c, somatic 2.88537
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.88077
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.85133
H2BC21 H2B clustered histone 21 2.84358
GADD45A growth arrest and DNA-damage-inducible, alpha 2.83867
FEZF2 FEZ family zinc finger 2 2.83131
DUSP8 dual specificity phosphatase 8 2.80723
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.79381
RAP1GAP2 RAP1 GTPase activating protein 2 2.77384
CTSL cathepsin L 2.76258
TERF2IP telomeric repeat binding factor 2, interacting protein 2.76193
ZBTB10 zinc finger and BTB domain containing 10 2.76074
CCNH cyclin H 2.75563
ZNF586 zinc finger protein 586 2.73975
IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2.72699
BLVRA biliverdin reductase A 2.70498
SPINT1 serine peptidase inhibitor, Kunitz type 1 2.70062
WDR13 WD repeat domain 13 2.68705
ADSS2 adenylosuccinate synthase 2 2.67543
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.67323
TNIP1 TNFAIP3 interacting protein 1 2.66782
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.66164
HTRA1 HtrA serine peptidase 1 2.65473
CDK7 cyclin-dependent kinase 7 2.6545
MAP7D1 MAP7 domain containing 1 2.6512
PTPN12 protein tyrosine phosphatase, non-receptor type 12 2.63993
YARS1 tyrosyl-tRNA synthetase 1 2.63961
KDM6B lysine (K)-specific demethylase 6B 2.63463
PPP1R15A protein phosphatase 1, regulatory subunit 15A 2.62714
ATF3 activating transcription factor 3 2.60863
PTPRF protein tyrosine phosphatase, receptor type, F 2.60507
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.59947
PRKCQ protein kinase C, theta 2.59607
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 2.58033
PYGB phosphorylase, glycogen; brain 2.57534
NDEL1 nudE neurodevelopment protein 1-like 1 2.55756
PTX3 pentraxin 3, long 2.54818
JUN jun proto-oncogene 2.54194
ATG2B autophagy related 2B 2.53953
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.5385
UPP1 uridine phosphorylase 1 2.5183
PRAF2 PRA1 domain family, member 2 2.51825
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 2.51604
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.51602
PLK3 polo-like kinase 3 2.51245
STAT5B signal transducer and activator of transcription 5B 2.50929
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.50655
ATOSB atos homolog B 2.4945
GARS1 glycyl-tRNA synthetase 1 2.48341
ITCH itchy E3 ubiquitin protein ligase 2.48216
GSDMB gasdermin B 2.48118
CCNA1 cyclin A1 2.47197
MAP3K2 mitogen-activated protein kinase kinase kinase 2 2.46511
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 2.46476
MSN moesin 2.46416
TRIM13 tripartite motif containing 13 2.4609
KALRN kalirin, RhoGEF kinase 2.45619
LOC128125814 uncharacterized LOC128125814 2.44794
GPC1 glypican 1 2.44196
TM6SF1 transmembrane 6 superfamily member 1 2.43924
FLNB filamin B, beta 2.4376
TMEM19 transmembrane protein 19 2.43484
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 2.42632
CCDC92 coiled-coil domain containing 92 2.42531
KLHL4 kelch-like family member 4 2.42097
ZNF362 zinc finger protein 362 2.41884
DUSP3 dual specificity phosphatase 3 2.4119
MARF1 meiosis regulator and mRNA stability factor 1 2.40567
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.40517
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.40266
HPCAL1 hippocalcin-like 1 2.40117
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.39906
F2RL1 coagulation factor II (thrombin) receptor-like 1 2.39165
TMC7 transmembrane channel-like 7 2.38712
LRP10 low density lipoprotein receptor-related protein 10 2.38112
FGF12 fibroblast growth factor 12 2.38031
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 2.37871
CYTH2 cytohesin 2 2.37399
ICAM5 intercellular adhesion molecule 5, telencephalin 2.37244
EXOC1 exocyst complex component 1 2.37008
REL v-rel avian reticuloendotheliosis viral oncogene homolog 2.36675
FABP2 fatty acid binding protein 2, intestinal 2.36441
ST18 suppression of tumorigenicity 18, zinc finger 2.36159
AFF4 AF4/FMR2 family, member 4 2.36081
RAP1GAP RAP1 GTPase activating protein 2.36035
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 2.35893
RB1CC1 RB1-inducible coiled-coil 1 2.35756
SMTN smoothelin 2.35157
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.33197
CCSER2 coiled-coil serine-rich protein 2 2.328
SCAI suppressor of cancer cell invasion 2.31942
GDI1 GDP dissociation inhibitor 1 2.31852
GLRX glutaredoxin (thioltransferase) 2.31768
TLK2 tousled-like kinase 2 2.31491
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 2.31102
VCL vinculin 2.30017
EPHA3 EPH receptor A3 2.30003
FOXJ3 forkhead box J3 2.29057
MAGIX MAGI family member, X-linked 2.28627
RASAL2 RAS protein activator like 2 2.2815
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 2.27965
S1PR1 sphingosine-1-phosphate receptor 1 2.27833
ZFAND5 zinc finger, AN1-type domain 5 2.27655
CTNND1 catenin (cadherin-associated protein), delta 1 2.27139
CFLAR CASP8 and FADD-like apoptosis regulator 2.27002
ACTN4 actinin, alpha 4 2.26873
STN1 STN1 subunit of CST complex 2.26862
ZFAND1 zinc finger, AN1-type domain 1 2.2637
MT1G metallothionein 1G 2.26339
LARP6 La ribonucleoprotein domain family, member 6 2.26079
APOBR apolipoprotein B receptor 2.2593
CD9 CD9 molecule 2.2575
ATF4 activating transcription factor 4 2.25416
EPS8 epidermal growth factor receptor pathway substrate 8 2.24856
LRRC8B leucine rich repeat containing 8 family, member B 2.24364
NR2C2 nuclear receptor subfamily 2, group C, member 2 2.24158
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 2.24134
H2BC17 H2B clustered histone 17 2.23742
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 2.23717
KIAA0408 KIAA0408 2.23518
MORC2 MORC family CW-type zinc finger 2 2.22898
HSPG2 heparan sulfate proteoglycan 2 2.22672
CSK c-src tyrosine kinase 2.22573
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.22278
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 2.22224
PLGLB2 plasminogen-like B2 2.22186
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.21952
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.2193
PLAUR plasminogen activator, urokinase receptor 2.21712
EVL Enah/Vasp-like 2.21207
FAM193A family with sequence similarity 193, member A 2.20752
CCNT1 cyclin T1 2.20724
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 2.20577
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 2.20215
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.20158
MEF2D myocyte enhancer factor 2D 2.20009
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.19501
PTK2 protein tyrosine kinase 2 2.19294
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 2.18478
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 2.18439
AXL AXL receptor tyrosine kinase 2.18422
BCL2L13 BCL2-like 13 (apoptosis facilitator) 2.18378
ZNF571 zinc finger protein 571 2.17994
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.1767
VNN1 vanin 1 2.17567
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.17405
TLR3 toll-like receptor 3 2.1733
KLF7 Kruppel-like factor 7 (ubiquitous) 2.17237
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent 2.1691
LSR lipolysis stimulated lipoprotein receptor 2.16755
PHLDA2 pleckstrin homology-like domain, family A, member 2 2.1674
PKN1 protein kinase N1 2.1664
JMJD1C jumonji domain containing 1C 2.16202
CCDC144A coiled-coil domain containing 144A 2.1575
LCOR ligand dependent nuclear receptor corepressor 2.15472
YY1AP1 YY1 associated protein 1 2.15181
WDR7 WD repeat domain 7 2.15061
CDK17 cyclin-dependent kinase 17 2.14116
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2.14047
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 2.13907
ZBTB35 zinc finger and BTB domain containing 35 2.1383
CYSLTR1 cysteinyl leukotriene receptor 1 2.13671
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 2.13511
KDM5A lysine (K)-specific demethylase 5A 2.12934
CNTNAP3B contactin associated protein-like 3B 2.12885
CDH9 cadherin 9, type 2 (T1-cadherin) 2.12532
CHN1 chimerin 1 2.11956
DGKE diacylglycerol kinase, epsilon 64kDa 2.11805
LIF leukemia inhibitory factor 2.11168
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.11134
TBC1D15 TBC1 domain family, member 15 2.10679
ZXDB zinc finger, X-linked, duplicated B 2.10077
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 2.09813
GPR39 G protein-coupled receptor 39 2.0977
MMRN2 multimerin 2 2.09635
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.09244
DOHH deoxyhypusine hydroxylase/monooxygenase 2.09133
DUSP5 dual specificity phosphatase 5 2.09102
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.09028
SLC38A2 solute carrier family 38, member 2 2.08887
STBD1 starch binding domain 1 2.08378
EXOC6B exocyst complex component 6B 2.08321
NARS1 asparaginyl-tRNA synthetase 1 2.08136
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.08121
KLHL24 kelch-like family member 24 2.0797
RSF1 remodeling and spacing factor 1 2.07662
PARP8 poly (ADP-ribose) polymerase family, member 8 2.07397
ITFG1 integrin alpha FG-GAP repeat containing 1 2.07233
IFRD1 interferon-related developmental regulator 1 2.07057
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa 2.06851
MARCHF5 membrane associated ring-CH-type finger 5 2.06833
CARS1 cysteinyl-tRNA synthetase 1 2.06796
NT5E 5'-nucleotidase, ecto (CD73) 2.06755
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2.0663
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.06181
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 2.06089
TMEM140 transmembrane protein 140 2.06052
MTERF3 mitochondrial transcription termination factor 3 2.05686
BSN bassoon presynaptic cytomatrix protein 2.05241
ZMYM5 zinc finger, MYM-type 5 2.04712
SSX1 synovial sarcoma, X breakpoint 1 2.04543
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 2.0445
MGLL monoglyceride lipase 2.04394
EMP1 epithelial membrane protein 1 2.04365
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 2.02262
GSPT1 G1 to S phase transition 1 2.02251
CAVIN2 caveolae associated protein 2 2.02004
PEDS1 plasmanylethanolamine desaturase 1 2.01642
TRIM23 tripartite motif containing 23 2.01436
RBM34 RNA binding motif protein 34 2.01162
RAI14 retinoic acid induced 14 2.01144
DGKB diacylglycerol kinase, beta 90kDa 2.01056
GREM1 gremlin 1, DAN family BMP antagonist 2.00891
KLRC4 killer cell lectin-like receptor subfamily C, member 4 2.00826
TAPT1 transmembrane anterior posterior transformation 1 2.00737
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.00698
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 2.00662
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 2.00508
H2BC6 H2B clustered histone 6 2.00126

decreased expression

Symbol Name Standardized Value
B4GAT1 beta-1,4-glucuronyltransferase 1 -10.0
BLCAP bladder cancer associated protein -8.64503
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -8.28937
TCTN1 tectonic family member 1 -7.40078
CCNB2 cyclin B2 -7.33866
NT5DC2 5'-nucleotidase domain containing 2 -7.20975
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -7.16909
MELK maternal embryonic leucine zipper kinase -6.87608
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -6.85342
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -6.50997
LDHD lactate dehydrogenase D -6.49005
ALDOC aldolase C, fructose-bisphosphate -6.21804
ARFIP2 ADP-ribosylation factor interacting protein 2 -5.8682
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.83773
PGAM4 phosphoglycerate mutase family member 4 -5.56314
STMN1 stathmin 1 -5.41539
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.3049
CDK1 cyclin-dependent kinase 1 -5.19775
THAP11 THAP domain containing 11 -5.18405
SOAT2 sterol O-acyltransferase 2 -5.16852
VAT1 vesicle amine transport 1 -5.16567
PSRC1 proline/serine-rich coiled-coil 1 -5.14421
PGM1 phosphoglucomutase 1 -5.05617
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.99464
ICAM3 intercellular adhesion molecule 3 -4.91561
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -4.76304
INTS3 integrator complex subunit 3 -4.74462
GTF2A2 general transcription factor IIA, 2, 12kDa -4.7085
CDC20 cell division cycle 20 -4.70106
LBR lamin B receptor -4.5741
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.52978
DERA deoxyribose-phosphate aldolase (putative) -4.49948
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -4.4253
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.33715
PROS1 protein S (alpha) -4.33276
CCDC86 coiled-coil domain containing 86 -4.32945
BIRC5 baculoviral IAP repeat containing 5 -4.32318
MYCBP MYC binding protein -4.29772
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -4.29147
CCNA2 cyclin A2 -4.20592
ADI1 acireductone dioxygenase 1 -4.12873
TOP2A topoisomerase (DNA) II alpha 170kDa -4.10388
TMEM97 transmembrane protein 97 -4.09191
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.97855
RPIA ribose 5-phosphate isomerase A -3.96616
NLRP2B NLR family pyrin domain containing 2B -3.93525
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.87383
RNASE7 ribonuclease, RNase A family, 7 -3.84969
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -3.83861
PLK1 polo-like kinase 1 -3.83267
TMEM109 transmembrane protein 109 -3.8323
HMOX1 heme oxygenase 1 -3.82662
UBE2C ubiquitin-conjugating enzyme E2C -3.8229
ECH1 enoyl CoA hydratase 1, peroxisomal -3.81584
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.7987
FGFR4 fibroblast growth factor receptor 4 -3.749
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.71419
NUP85 nucleoporin 85kDa -3.68448
ASF1B anti-silencing function 1B histone chaperone -3.64567
CHMP6 charged multivesicular body protein 6 -3.63709
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.62572
NUP62 nucleoporin 62kDa -3.62008
NUCB2 nucleobindin 2 -3.52194
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.52155
PEG10 paternally expressed 10 -3.50149
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -3.48529
EGF epidermal growth factor -3.46606
PXMP2 peroxisomal membrane protein 2, 22kDa -3.46499
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -3.42615
PARP1 poly (ADP-ribose) polymerase 1 -3.40956
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.33456
CBR1 carbonyl reductase 1 -3.31533
CERK ceramide kinase -3.30885
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.29752
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.28305
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -3.27358
TRMT5 tRNA methyltransferase 5 -3.27135
MLEC malectin -3.26731
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.26635
HMGA2 high mobility group AT-hook 2 -3.26378
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -3.26055
PCCB propionyl CoA carboxylase, beta polypeptide -3.24871
TFDP1 transcription factor Dp-1 -3.23673
PCNA proliferating cell nuclear antigen -3.23213
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -3.22852
RUVBL1 RuvB-like AAA ATPase 1 -3.22194
UBE3C ubiquitin protein ligase E3C -3.19115
MSH2 mutS homolog 2 -3.16308
PEPD peptidase D -3.15824
NISCH nischarin -3.1555
GINS2 GINS complex subunit 2 (Psf2 homolog) -3.14936
POLR1A polymerase (RNA) I polypeptide A, 194kDa -3.11834
PGRMC1 progesterone receptor membrane component 1 -3.09635
ZNF274 zinc finger protein 274 -3.08847
USP6NL USP6 N-terminal like -3.08704
CD320 CD320 molecule -3.08189
MRPL11 mitochondrial ribosomal protein L11 -3.08179
TARBP2 TAR (HIV-1) RNA binding protein 2 -3.07625
IDI1 isopentenyl-diphosphate delta isomerase 1 -3.07396
AURKB aurora kinase B -3.07109
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.06516
TMCO1 transmembrane and coiled-coil domains 1 -3.06298
COA3 cytochrome c oxidase assembly factor 3 -3.05459
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.05412
TMEM106C transmembrane protein 106C -3.01163
FEN1 flap structure-specific endonuclease 1 -2.98769
NENF neudesin neurotrophic factor -2.9795
ZDHHC6 zinc finger, DHHC-type containing 6 -2.96734
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.96291
GPC3 glypican 3 -2.94583
ANKRD10 ankyrin repeat domain 10 -2.94331
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.91786
C2CD5 C2 calcium-dependent domain containing 5 -2.9178
CCNE1 cyclin E1 -2.90044
PYGL phosphorylase, glycogen, liver -2.89586
CDK4 cyclin-dependent kinase 4 -2.89007
COG4 component of oligomeric golgi complex 4 -2.87667
ITGB1BP1 integrin beta 1 binding protein 1 -2.86363
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.85611
TATDN2 TatD DNase domain containing 2 -2.85366
MSH6 mutS homolog 6 -2.83742
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.83484
PDIA5 protein disulfide isomerase family A, member 5 -2.83278
TXLNA taxilin alpha -2.8294
TBC1D10C TBC1 domain family, member 10C -2.82072
ZW10 zw10 kinetochore protein -2.81357
TK1 thymidine kinase 1, soluble -2.78784
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.75767
LAGE3 L antigen family, member 3 -2.73311
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.73201
PRUNE1 prune exopolyphosphatase 1 -2.73199
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.70953
HSPB1 heat shock 27kDa protein 1 -2.70815
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.68268
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.68133
GLOD4 glyoxalase domain containing 4 -2.67384
RPA3 replication protein A3, 14kDa -2.66824
RFC2 replication factor C (activator 1) 2, 40kDa -2.66793
ZWINT ZW10 interacting kinetochore protein -2.66739
POLR2G polymerase (RNA) II (DNA directed) polypeptide G -2.66613
PRCP prolylcarboxypeptidase (angiotensinase C) -2.6648
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.66447
SPDEF SAM pointed domain containing ETS transcription factor -2.66266
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.6611
EMC9 ER membrane protein complex subunit 9 -2.65711
GSTM2 glutathione S-transferase mu 2 (muscle) -2.65374
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.64556
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.62896
HSPA1A heat shock 70kDa protein 1A -2.62874
CTSG cathepsin G -2.62774
MRPL12 mitochondrial ribosomal protein L12 -2.6178
MDH1 malate dehydrogenase 1, NAD (soluble) -2.60886
TEFM transcription elongation factor, mitochondrial -2.60591
MSMO1 methylsterol monooxygenase 1 -2.60367
STIMATE STIM activating enhancer -2.60034
TMEM50A transmembrane protein 50A -2.5951
DDB2 damage-specific DNA binding protein 2, 48kDa -2.59479
ANAPC15 anaphase promoting complex subunit 15 -2.59062
HAT1 histone acetyltransferase 1 -2.59008
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -2.58744
AKAP8 A kinase (PRKA) anchor protein 8 -2.57175
TTC38 tetratricopeptide repeat domain 38 -2.55271
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.54829
ZSCAN5A zinc finger and SCAN domain containing 5A -2.53632
TRAPPC3 trafficking protein particle complex 3 -2.52754
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.52714
DEXI Dexi homolog (mouse) -2.50742
FAM174B family with sequence similarity 174, member B -2.49359
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.48379
CPVL carboxypeptidase, vitellogenic-like -2.48011
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.47752
TEDC2 tubulin epsilon and delta complex 2 -2.476
CDKN3 cyclin-dependent kinase inhibitor 3 -2.47525
UNC119B unc-119 homolog B (C. elegans) -2.46443
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -2.46127
SNF8 SNF8, ESCRT-II complex subunit -2.45949
RBM15B RNA binding motif protein 15B -2.43548
GLRX5 glutaredoxin 5 -2.42553
KIF15 kinesin family member 15 -2.42313
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -2.42111
TOR3A torsin family 3, member A -2.41992
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A -2.41977
AURKC aurora kinase C -2.39871
BMP4 bone morphogenetic protein 4 -2.38393
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.37858
ALG6 ALG6, alpha-1,3-glucosyltransferase -2.37047
NASP nuclear autoantigenic sperm protein (histone-binding) -2.36762
TRAPPC4 trafficking protein particle complex 4 -2.36637
LRRC61 leucine rich repeat containing 61 -2.35787
RMI1 RecQ mediated genome instability 1 -2.3458
GEMIN6 gem (nuclear organelle) associated protein 6 -2.33834
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -2.33605
MCM10 minichromosome maintenance complex component 10 -2.32846
ZNF443 zinc finger protein 443 -2.32825
UXT ubiquitously-expressed, prefoldin-like chaperone -2.32248
MTARC1 mitochondrial amidoxime reducing component 1 -2.32236
GAMT guanidinoacetate N-methyltransferase -2.31493
PRR7 proline rich 7 (synaptic) -2.31332
TMEM161A transmembrane protein 161A -2.31086
SIVA1 SIVA1, apoptosis-inducing factor -2.3103
UNC119 unc-119 homolog (C. elegans) -2.30153
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.29478
GTPBP3 GTP binding protein 3 (mitochondrial) -2.2874
CETN2 centrin, EF-hand protein, 2 -2.28574
TSNAXIP1 translin-associated factor X interacting protein 1 -2.28537
HMGN3 high mobility group nucleosomal binding domain 3 -2.28081
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.27976
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.27618
WRAP53 WD repeat containing, antisense to TP53 -2.27422
MGST2 microsomal glutathione S-transferase 2 -2.2624
CENPA centromere protein A -2.25576
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.25378
KIFC1 kinesin family member C1 -2.25353
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.24985
ATP5IF1 ATP synthase inhibitory factor subunit 1 -2.24883
AURKA aurora kinase A -2.24807
ICMT isoprenylcysteine carboxyl methyltransferase -2.24529
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -2.23899
TMX1 thioredoxin-related transmembrane protein 1 -2.23647
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.23618
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.23317
XYLT2 xylosyltransferase II -2.23185
GALK1 galactokinase 1 -2.22555
CISD1 CDGSH iron sulfur domain 1 -2.22536
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -2.22111
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.22008
SPA17 sperm autoantigenic protein 17 -2.21974
CCL17 chemokine (C-C motif) ligand 17 -2.21839
WFS1 Wolfram syndrome 1 (wolframin) -2.19712
RPS5 ribosomal protein S5 -2.1963
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.19458
ANXA7 annexin A7 -2.19412
GSTM5 glutathione S-transferase mu 5 -2.19339
ABHD14A abhydrolase domain containing 14A -2.19298
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.19192
CDC25A cell division cycle 25A -2.18785
SH3D19 SH3 domain containing 19 -2.18422
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.18155
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle -2.18092
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 -2.17666
CDC6 cell division cycle 6 -2.17402
CHMP4B charged multivesicular body protein 4B -2.17328
ARID3A AT rich interactive domain 3A (BRIGHT-like) -2.17285
SNX11 sorting nexin 11 -2.16473
PIGF phosphatidylinositol glycan anchor biosynthesis, class F -2.15457
SMCO4 single-pass membrane protein with coiled-coil domains 4 -2.1503
OCEL1 occludin/ELL domain containing 1 -2.14998
LYZ lysozyme -2.14626
SKIC8 SKI8 subunit of superkiller complex -2.14517
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.13934
DHCR24 24-dehydrocholesterol reductase -2.13867
TIPIN TIMELESS interacting protein -2.13523
CCL13 chemokine (C-C motif) ligand 13 -2.13519
PLSCR1 phospholipid scramblase 1 -2.13411
RPUSD2 RNA pseudouridylate synthase domain containing 2 -2.13151
CYREN cell cycle regulator of NHEJ -2.13056
PDIA6 protein disulfide isomerase family A, member 6 -2.12896
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 -2.12068
TFB1M transcription factor B1, mitochondrial -2.11885
SASH3 SAM and SH3 domain containing 3 -2.11656
INTS9 integrator complex subunit 9 -2.11584
REEP2 receptor accessory protein 2 -2.11292
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.11232
CENPX centromere protein X -2.11145
MIS18A MIS18 kinetochore protein A -2.10714
IFT52 intraflagellar transport 52 -2.10444
HDAC1 histone deacetylase 1 -2.10376
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.10363
IL17RB interleukin 17 receptor B -2.1035
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.10338
RIOX1 ribosomal oxygenase 1 -2.10119
KIF11 kinesin family member 11 -2.10067
SLC22A14 solute carrier family 22, member 14 -2.09933
EAPP E2F-associated phosphoprotein -2.0983
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -2.09826
CCNO cyclin O -2.09034
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.08599
DENND10 DENN domain containing 10 -2.08408
ARHGAP19 Rho GTPase activating protein 19 -2.08324
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.08209
NCAPG2 non-SMC condensin II complex, subunit G2 -2.07836
MNS1 meiosis-specific nuclear structural 1 -2.0762
TMPO thymopoietin -2.07574
CETN3 centrin, EF-hand protein, 3 -2.07483
DNAAF2 dynein, axonemal, assembly factor 2 -2.07417
FKBP3 FK506 binding protein 3, 25kDa -2.0728
LYRM1 LYR motif containing 1 -2.07226
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -2.07156
F13A1 coagulation factor XIII, A1 polypeptide -2.06501
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.06288
SPPL2A signal peptide peptidase like 2A -2.05975
COQ3 coenzyme Q3 methyltransferase -2.05849
GLB1 galactosidase, beta 1 -2.05823
ATP5MC1 ATP synthase membrane subunit c locus 1 -2.05659
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.05521
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.05404
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -2.05364
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -2.05092
TRIM32 tripartite motif containing 32 -2.0495
FBXO5 F-box protein 5 -2.04774
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.04509
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.04356
XKR8 XK, Kell blood group complex subunit-related family, member 8 -2.04335
TMPRSS6 transmembrane protease, serine 6 -2.04121
E2F6 E2F transcription factor 6 -2.03985
HOXC8 homeobox C8 -2.03851
NUP37 nucleoporin 37kDa -2.03769
HSPB2 heat shock 27kDa protein 2 -2.0368
MXRA8 matrix-remodelling associated 8 -2.03554
ZNF83 zinc finger protein 83 -2.0341
WDR73 WD repeat domain 73 -2.03314
AVPR1B arginine vasopressin receptor 1B -2.0279
MYL11 myosin light chain 11 -2.02175
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.02099
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -2.01769
MXD3 MAX dimerization protein 3 -2.01635
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.0094
GYG2 glycogenin 2 -2.00795
FASTKD3 FAST kinase domains 3 -2.00166