CRCGN012_HEPG2_24H:G08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-[(1,1,2,2-tetrachloroethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1h-isoindole-1,3(2h)-dione 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

187 genes differentially expressed following the CRCGN012_HEPG2_24H:G08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
C2CD2 C2 calcium-dependent domain containing 2 7.07108
PPARG peroxisome proliferator-activated receptor gamma 6.62197
NOTCH1 notch 1 6.56374
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.84513
CNPY3 canopy FGF signaling regulator 3 4.67721
TUBB6 tubulin, beta 6 class V 4.35764
LRP10 low density lipoprotein receptor-related protein 10 4.32735
CHN1 chimerin 1 4.27863
IER3 immediate early response 3 4.24368
INPP1 inositol polyphosphate-1-phosphatase 4.20769
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.14449
CBR1 carbonyl reductase 1 4.11575
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.93648
FOSL1 FOS-like antigen 1 3.85788
BAMBI BMP and activin membrane-bound inhibitor 3.84206
BLMH bleomycin hydrolase 3.80237
TXNRD1 thioredoxin reductase 1 3.71302
SQSTM1 sequestosome 1 3.56196
ALAS1 5'-aminolevulinate synthase 1 3.52998
RPL39L ribosomal protein L39-like 3.51603
ABHD4 abhydrolase domain containing 4 3.43714
TEX10 testis expressed 10 3.3889
WDR7 WD repeat domain 7 3.29057
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.21866
EGR1 early growth response 1 3.16121
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.15961
TRIB1 tribbles pseudokinase 1 3.13723
CCDC85B coiled-coil domain containing 85B 3.11839
NPDC1 neural proliferation, differentiation and control, 1 3.04523
TOMM34 translocase of outer mitochondrial membrane 34 3.01073
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.98096
MSRA methionine sulfoxide reductase A 2.89835
PRR15L proline rich 15-like 2.89289
TIMP2 TIMP metallopeptidase inhibitor 2 2.78897
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.77977
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.77268
PRKCQ protein kinase C, theta 2.76482
SNAP25 synaptosomal-associated protein, 25kDa 2.76105
LBHD1 LBH domain containing 1 2.7591
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.74275
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.74159
ADGRE5 adhesion G protein-coupled receptor E5 2.72906
SQOR sulfide quinone oxidoreductase 2.72444
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.72092
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.69356
CAPN1 calpain 1, (mu/I) large subunit 2.66937
PAK1IP1 PAK1 interacting protein 1 2.63264
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.52615
GSTZ1 glutathione S-transferase zeta 1 2.52417
SMAD3 SMAD family member 3 2.49742
TERF2IP telomeric repeat binding factor 2, interacting protein 2.48453
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.46614
MEST mesoderm specific transcript 2.45501
DUSP6 dual specificity phosphatase 6 2.4357
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.43305
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.38333
SMIM40 small integral membrane protein 40 2.351
UPP1 uridine phosphorylase 1 2.33479
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.32325
MVP major vault protein 2.31409
STX4 syntaxin 4 2.26268
ATP11B ATPase, class VI, type 11B 2.26045
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.2444
TSPO translocator protein (18kDa) 2.23211
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.22233
GOLT1B golgi transport 1B 2.21505
ZNF195 zinc finger protein 195 2.21118
TMX2 thioredoxin-related transmembrane protein 2 2.20848
SLC35F2 solute carrier family 35, member F2 2.19318
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa 2.18106
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 2.17617
RAB13 RAB13, member RAS oncogene family 2.15488
RAI14 retinoic acid induced 14 2.13454
TENT4A terminal nucleotidyltransferase 4A 2.12997
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 2.10806
TBPL1 TBP-like 1 2.09574
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.08567
TICAM1 toll-like receptor adaptor molecule 1 2.07683
PLK3 polo-like kinase 3 2.07071
CEMIP2 cell migration inducing hyaluronidase 2 2.06662
FHOD1 formin homology 2 domain containing 1 2.06434
BUD31 BUD31 homolog (S. cerevisiae) 2.05458
MAN1B1 mannosidase, alpha, class 1B, member 1 2.05259
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.04995
CTSD cathepsin D 2.0395
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.01342

decreased expression

Symbol Name Standardized Value
TCTN1 tectonic family member 1 -7.05411
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -6.86131
PYCR1 pyrroline-5-carboxylate reductase 1 -6.34126
LDHD lactate dehydrogenase D -6.31078
ANKRD10 ankyrin repeat domain 10 -5.35442
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.09478
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.86131
FGFR4 fibroblast growth factor receptor 4 -4.55502
CDC20 cell division cycle 20 -4.54519
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.50264
ZW10 zw10 kinetochore protein -4.50174
ZMIZ1 zinc finger, MIZ-type containing 1 -4.49595
PGM1 phosphoglucomutase 1 -3.89021
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -3.80846
STMN1 stathmin 1 -3.79353
KDM3A lysine (K)-specific demethylase 3A -3.78898
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.68398
CD320 CD320 molecule -3.66176
ISOC1 isochorismatase domain containing 1 -3.65606
THAP11 THAP domain containing 11 -3.58961
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.52884
KLHDC2 kelch domain containing 2 -3.48987
USP6NL USP6 N-terminal like -3.4487
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.32079
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.30357
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.20346
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.1858
ADI1 acireductone dioxygenase 1 -3.16803
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.09498
PSRC1 proline/serine-rich coiled-coil 1 -3.09097
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.06321
LBR lamin B receptor -3.04003
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.01906
SPAG4 sperm associated antigen 4 -3.0102
MYLK myosin light chain kinase -2.99652
UBE3C ubiquitin protein ligase E3C -2.98712
PLK1 polo-like kinase 1 -2.92638
PHGDH phosphoglycerate dehydrogenase -2.92606
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.8641
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.86182
CDK1 cyclin-dependent kinase 1 -2.83444
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.82394
FBXL12 F-box and leucine-rich repeat protein 12 -2.80193
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.80186
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.80095
RBM6 RNA binding motif protein 6 -2.73368
EGF epidermal growth factor -2.72691
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.72003
NT5DC2 5'-nucleotidase domain containing 2 -2.70532
FAIM Fas apoptotic inhibitory molecule -2.68682
TM9SF3 transmembrane 9 superfamily member 3 -2.63733
CPVL carboxypeptidase, vitellogenic-like -2.61179
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.55423
APOA2 apolipoprotein A-II -2.51672
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.50006
APOA1 apolipoprotein A-I -2.49522
SOAT2 sterol O-acyltransferase 2 -2.47268
ALDOC aldolase C, fructose-bisphosphate -2.47031
HMOX1 heme oxygenase 1 -2.42605
AMBP alpha-1-microglobulin/bikunin precursor -2.41717
HADH hydroxyacyl-CoA dehydrogenase -2.41581
GNAS GNAS complex locus -2.39612
APOC3 apolipoprotein C-III -2.39353
FBF1 Fas (TNFRSF6) binding factor 1 -2.36009
ZNF76 zinc finger protein 76 -2.32748
PEG10 paternally expressed 10 -2.31403
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.30065
APOB apolipoprotein B -2.29935
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.29652
C1R complement component 1, r subcomponent -2.25925
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.25827
NRIP1 nuclear receptor interacting protein 1 -2.24036
MXRA8 matrix-remodelling associated 8 -2.22054
AHSG alpha-2-HS-glycoprotein -2.17434
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.16347
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -2.16327
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.15959
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -2.15845
FAM110A family with sequence similarity 110, member A -2.14423
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.136
MAP7 microtubule-associated protein 7 -2.13215
MAPK13 mitogen-activated protein kinase 13 -2.11885
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.10905
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.10686
HDAC1 histone deacetylase 1 -2.10066
ERBB3 erb-b2 receptor tyrosine kinase 3 -2.09805
CCNA2 cyclin A2 -2.08717
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 -2.08268
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.07678
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -2.07028
GPC3 glypican 3 -2.06367
SSBP2 single-stranded DNA binding protein 2 -2.06007
KIFC1 kinesin family member C1 -2.05937
CDC25B cell division cycle 25B -2.05464
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -2.04152
ETFB electron-transfer-flavoprotein, beta polypeptide -2.03835
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 -2.03314
PROS1 protein S (alpha) -2.03176
MYL9 myosin, light chain 9, regulatory -2.01173
RNF167 ring finger protein 167 -2.00092