| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-[(1,1,2,2-tetrachloroethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1h-isoindole-1,3(2h)-dione 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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76 genes differentially expressed following the CRCGN012_HEPG2_24H:G09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 10.0 |
| INPP1 | inositol polyphosphate-1-phosphatase | 4.81922 |
| TUBB6 | tubulin, beta 6 class V | 4.10652 |
| KIFBP | kinesin family binding protein | 3.6316 |
| SQOR | sulfide quinone oxidoreductase | 3.58149 |
| STIMATE | STIM activating enhancer | 3.55979 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 3.44516 |
| PPARG | peroxisome proliferator-activated receptor gamma | 3.33181 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 3.18571 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 3.18133 |
| IER3 | immediate early response 3 | 3.02546 |
| KDM5A | lysine (K)-specific demethylase 5A | 2.95146 |
| LCN2 | lipocalin 2 | 2.91926 |
| SLC75A1 | solute carrier family 75 member 1 | 2.87762 |
| KLHL9 | kelch-like family member 9 | 2.85741 |
| MICALL1 | MICAL-like 1 | 2.83249 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.75718 |
| ACOT9 | acyl-CoA thioesterase 9 | 2.68239 |
| FOSL1 | FOS-like antigen 1 | 2.66753 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2.62943 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 2.58148 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 2.57814 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 2.57262 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 2.55858 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.5208 |
| TEX10 | testis expressed 10 | 2.46134 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | 2.39393 |
| GLRX | glutaredoxin (thioltransferase) | 2.32107 |
| EGR1 | early growth response 1 | 2.28511 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.27811 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 2.25023 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 2.20103 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | 2.14088 |
| ORMDL2 | ORMDL sphingolipid biosynthesis regulator 2 | 2.13254 |
| HCFC1R1 | host cell factor C1 regulator 1 (XPO1 dependent) | 2.0996 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 2.0698 |
| DSG2 | desmoglein 2 | 2.04826 |
| MAP7D1 | MAP7 domain containing 1 | 2.03463 |
| HAT1 | histone acetyltransferase 1 | 2.03226 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB2 | cyclin B2 | -7.73483 |
| ISOC1 | isochorismatase domain containing 1 | -5.95244 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.71949 |
| ZW10 | zw10 kinetochore protein | -5.31473 |
| TCERG1 | transcription elongation regulator 1 | -5.15289 |
| TCTN1 | tectonic family member 1 | -4.85939 |
| FGFR4 | fibroblast growth factor receptor 4 | -4.12517 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -4.01532 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -3.90347 |
| CCDC86 | coiled-coil domain containing 86 | -3.20758 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.16439 |
| USP6NL | USP6 N-terminal like | -3.14574 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -3.10717 |
| UBE3C | ubiquitin protein ligase E3C | -3.00431 |
| KLHDC2 | kelch domain containing 2 | -2.74588 |
| ANKRD10 | ankyrin repeat domain 10 | -2.69045 |
| PDHX | pyruvate dehydrogenase complex, component X | -2.65864 |
| PRPF4 | pre-mRNA processing factor 4 | -2.58574 |
| PHGDH | phosphoglycerate dehydrogenase | -2.55791 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | -2.51396 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.50855 |
| LBR | lamin B receptor | -2.49867 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.44084 |
| HMOX1 | heme oxygenase 1 | -2.34676 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -2.17098 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -2.16297 |
| NAT10 | N-acetyltransferase 10 (GCN5-related) | -2.16264 |
| SOAT2 | sterol O-acyltransferase 2 | -2.15781 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -2.10083 |
| TESK2 | testis-specific kinase 2 | -2.09917 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | -2.08988 |
| KLF1 | Kruppel-like factor 1 (erythroid) | -2.06359 |
| TCEA2 | transcription elongation factor A (SII), 2 | -2.02772 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.01958 |
| KIF18A | kinesin family member 18A | -2.01772 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | -2.01579 |
| AIRIM | AFG2 interacting ribosome maturation factor | -2.00418 |
