| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-[(1,1,2,2-tetrachloroethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1h-isoindole-1,3(2h)-dione 5.02 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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63 genes differentially expressed following the CRCGN012_HEPG2_24H:G10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| BACE2 | beta-site APP-cleaving enzyme 2 | 6.0554 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 5.96305 |
| STIMATE | STIM activating enhancer | 5.87289 |
| LCN2 | lipocalin 2 | 4.6342 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 4.05664 |
| KLHL21 | kelch-like family member 21 | 3.74528 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 3.59686 |
| CHN1 | chimerin 1 | 3.58462 |
| HSPA1A | heat shock 70kDa protein 1A | 3.43727 |
| UBQLN2 | ubiquilin 2 | 3.35799 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 3.35238 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 3.33069 |
| SFTPB | surfactant protein B | 3.13811 |
| SQOR | sulfide quinone oxidoreductase | 2.88269 |
| CHMP6 | charged multivesicular body protein 6 | 2.87989 |
| ATP11B | ATPase, class VI, type 11B | 2.72328 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 2.67927 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 2.65163 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.59736 |
| MCM3 | minichromosome maintenance complex component 3 | 2.54861 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 2.49619 |
| EPN2 | epsin 2 | 2.42717 |
| AMDHD2 | amidohydrolase domain containing 2 | 2.31732 |
| MARCHF5 | membrane associated ring-CH-type finger 5 | 2.31459 |
| NECAB3 | N-terminal EF-hand calcium binding protein 3 | 2.27092 |
| SLC75A1 | solute carrier family 75 member 1 | 2.24839 |
| IER3 | immediate early response 3 | 2.12135 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 2.10462 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 2.09244 |
| NOL9 | nucleolar protein 9 | 2.00104 |
| CBR3 | carbonyl reductase 3 | 2.00002 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -8.13194 |
| LDHD | lactate dehydrogenase D | -7.4054 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -6.13326 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -6.00632 |
| CCNB1 | cyclin B1 | -5.87636 |
| CCNB2 | cyclin B2 | -5.19819 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -5.00887 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -4.47754 |
| ENOPH1 | enolase-phosphatase 1 | -4.35887 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -4.11719 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -3.97362 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -3.75823 |
| CDC20 | cell division cycle 20 | -3.6816 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -3.39596 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.37482 |
| RGS2 | regulator of G-protein signaling 2 | -3.25778 |
| TLCD3A | TLC domain containing 3A | -3.07908 |
| TRIB3 | tribbles pseudokinase 3 | -3.05201 |
| CHMP4B | charged multivesicular body protein 4B | -2.99439 |
| ADI1 | acireductone dioxygenase 1 | -2.98216 |
| VDAC1 | voltage-dependent anion channel 1 | -2.76958 |
| TCTN1 | tectonic family member 1 | -2.68156 |
| KDM3A | lysine (K)-specific demethylase 3A | -2.64576 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.5969 |
| CPNE3 | copine III | -2.4591 |
| PCNA | proliferating cell nuclear antigen | -2.4427 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.4391 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -2.19807 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.14079 |
| COG2 | component of oligomeric golgi complex 2 | -2.04354 |
| PCTP | phosphatidylcholine transfer protein | -2.01686 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.01271 |
