CRCGN012_HEPG2_24H:G11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-[(1,1,2,2-tetrachloroethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1h-isoindole-1,3(2h)-dione 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN012_HEPG2_24H:G11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GATA3 GATA binding protein 3 5.30434
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.17092
NOTCH1 notch 1 4.05687
CHN1 chimerin 1 3.92202
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.59499
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.02199
GPATCH8 G patch domain containing 8 2.43457
CYCS cytochrome c, somatic 2.40773
GARRE1 granule associated Rac and RHOG effector 1 2.35807
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.27426
SYNE2 spectrin repeat containing, nuclear envelope 2 2.25934
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.2566
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 2.18078
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 2.15916
EVL Enah/Vasp-like 2.14971
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.11559
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.06073
TIAM1 T-cell lymphoma invasion and metastasis 1 2.03735

decreased expression

Symbol Name Standardized Value
CCDC86 coiled-coil domain containing 86 -7.84192
SLC35F2 solute carrier family 35, member F2 -7.35644
NGRN neugrin, neurite outgrowth associated -6.34605
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -6.15887
CCNB1 cyclin B1 -4.98146
THAP11 THAP domain containing 11 -4.77772
TRIB3 tribbles pseudokinase 3 -4.25324
ISOC1 isochorismatase domain containing 1 -4.19913
KDM3A lysine (K)-specific demethylase 3A -3.98239
LDHD lactate dehydrogenase D -3.8987
SOAT2 sterol O-acyltransferase 2 -3.65776
MAP7 microtubule-associated protein 7 -3.61612
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.59821
ADI1 acireductone dioxygenase 1 -3.59487
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.45402
PECR peroxisomal trans-2-enoyl-CoA reductase -3.45353
PRPF4 pre-mRNA processing factor 4 -3.42455
PLK1 polo-like kinase 1 -3.42013
WASHC4 WASH complex subunit 4 -3.33523
MAPK13 mitogen-activated protein kinase 13 -3.06074
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.03536
VDAC1 voltage-dependent anion channel 1 -3.00134
ITGB1BP1 integrin beta 1 binding protein 1 -2.89727
RGS2 regulator of G-protein signaling 2 -2.8273
UBE3C ubiquitin protein ligase E3C -2.39616
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.37806
SIGLEC15 sialic acid binding Ig-like lectin 15 -2.30546
CAPN1 calpain 1, (mu/I) large subunit -2.29765
MPC2 mitochondrial pyruvate carrier 2 -2.21014
OXA1L oxidase (cytochrome c) assembly 1-like -2.13204
XPO7 exportin 7 -2.06638
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.06323
GDF15 growth differentiation factor 15 -2.06248
YME1L1 YME1-like 1 ATPase -2.047
PRPF19 pre-mRNA processing factor 19 -2.03453