| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-[(1,1,2,2-tetrachloroethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1h-isoindole-1,3(2h)-dione 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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78 genes differentially expressed following the CRCGN012_HEPG2_24H:G12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 10.0 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 8.5095 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 7.54608 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 7.33254 |
| E2F2 | E2F transcription factor 2 | 5.87519 |
| CCL2 | chemokine (C-C motif) ligand 2 | 5.31744 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 4.3271 |
| EVL | Enah/Vasp-like | 4.19448 |
| LCN2 | lipocalin 2 | 4.19098 |
| CSK | c-src tyrosine kinase | 3.83275 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.78147 |
| CDC45 | cell division cycle 45 | 3.75479 |
| RPL39L | ribosomal protein L39-like | 3.7544 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 3.71364 |
| UBQLN2 | ubiquilin 2 | 3.59051 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.40222 |
| NOTCH1 | notch 1 | 3.00509 |
| PFKL | phosphofructokinase, liver | 2.90774 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 2.7595 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.7279 |
| MELK | maternal embryonic leucine zipper kinase | 2.65545 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.62281 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.57883 |
| ABHD6 | abhydrolase domain containing 6 | 2.55837 |
| EPHB2 | EPH receptor B2 | 2.55454 |
| VGLL4 | vestigial-like family member 4 | 2.55392 |
| GPX2 | glutathione peroxidase 2 | 2.28525 |
| TMEM106C | transmembrane protein 106C | 2.17943 |
| TM4SF4 | transmembrane 4 L six family member 4 | 2.1688 |
| DUX4 | double homeobox 4 | 2.1059 |
| WDTC1 | WD and tetratricopeptide repeats 1 | 2.1032 |
| TBL3 | transducin (beta)-like 3 | 2.09528 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 2.08797 |
| SDK2 | sidekick cell adhesion molecule 2 | 2.07151 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 2.06537 |
| GC | group-specific component (vitamin D binding protein) | 2.05537 |
| AAAS | achalasia, adrenocortical insufficiency, alacrimia | 2.04121 |
| ADGRB1 | adhesion G protein-coupled receptor B1 | 2.03573 |
| PIH1D1 | PIH1 domain containing 1 | 2.03082 |
| RRP7A | ribosomal RNA processing 7 homolog A (S. cerevisiae) | 2.03038 |
| SNRPN | small nuclear ribonucleoprotein polypeptide N | 2.02618 |
| WDR4 | WD repeat domain 4 | 2.01999 |
| HKDC1 | hexokinase domain containing 1 | 2.00782 |
| SIGLEC15 | sialic acid binding Ig-like lectin 15 | 2.00545 |
| LAS1L | LAS1-like (S. cerevisiae) | 2.0037 |
| SSTR1 | somatostatin receptor 1 | 2.00207 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -9.61427 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -6.40866 |
| PCNA | proliferating cell nuclear antigen | -5.97777 |
| GNAS | GNAS complex locus | -4.82941 |
| CCNB2 | cyclin B2 | -4.59177 |
| TP53BP2 | tumor protein p53 binding protein 2 | -4.57038 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.36179 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -4.22291 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.91015 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -3.84166 |
| LDHD | lactate dehydrogenase D | -3.76142 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -3.70369 |
| ADI1 | acireductone dioxygenase 1 | -3.53477 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -3.49421 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -3.13305 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -2.99321 |
| PDHX | pyruvate dehydrogenase complex, component X | -2.8892 |
| SIRT1 | sirtuin 1 | -2.7788 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -2.77362 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.7556 |
| YME1L1 | YME1-like 1 ATPase | -2.48821 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.40691 |
| WDR26 | WD repeat domain 26 | -2.32943 |
| PSMA1 | proteasome (prosome, macropain) subunit, alpha type, 1 | -2.28441 |
| IPO13 | importin 13 | -2.19593 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.18641 |
| NVL | nuclear VCP-like | -2.13438 |
| TDP2 | tyrosyl-DNA phosphodiesterase 2 | -2.08807 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.07627 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.0587 |
| ZSCAN26 | zinc finger and SCAN domain containing 26 | -2.03875 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -2.02153 |
